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| Analysis of medication rule of Professor Wang Yaoxian in the treatment IgA nephropathy based on data mining |
| AI Sinan ZHENG Huijuan LI Danting TAO Jiayin YIN Shihui CAO Boning KANG Yi WANG Yaoxian▲ |
Department of Nephrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
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Abstract Objective To explore the medication rule of Professor Wang Yaoxian in the treatment of IgA nephropathy based on the prescription data of Professor Wang Yaoxian’s clinical outpatient cases. Methods With the prescription of the outpatient patients of Professor Wang Yaoxian as the data source from September 2018 to October 2021, the nature flavour, and channel trepism analysis, frequency statistical analysis, association analysis, and cluster analysis of the drugs were carried out to explore the law of drug application. Results There were 93 prescriptions that met the inclusion criteria, with a total of 160 herbs. The most common nature of these drugs was cold, the most common flavors was sweet, and the most common channel tropism was liver meridians. Among them, astragalus, turtle shells, and soil turtle insects were most frequently used. The common drug couples were seaweed and turtle shell, peach kernel and leech. The common collocation principles were mainly to activate blood and remove blood stasis, eliminate mass and dissipate knots, invigorate the spleen, eliminate wind and diuresis, invigorate the kidney and activate blood, dispel wind, clear heat and disperse dampness, and activate blood and cool blood. Conclusion Professor Wang Yaoxian in the treatment of IgA nephropathy is combined with the theory of mechanism differentiation, which is often combined with drugs such as supplementing qi and strengthening vital qi, dispelling wind and eliminating dumpness, promoting blood circulation and removing blood stasis and clearing collagals, eliminating disease and dispersing knot.
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