基于数据挖掘的局灶性子宫腺肌病不同年龄段用药规律分析

doi:10.20047/j.issn1673-7210.2023.14.28

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Abstract Objective To analyze the medication rule of focal adenomyopathy (AM) patients of different ages in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, so as to expand the idea of conservative and phased treatment of AM. Methods Data of focal AM patients in the outpatient department of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2012 to December 2017 were collected. Frequency analysis, multi-scale backbone network analysis, and other data mining methods were used to summarize the population distribution, high-frequency drug use, efficacy ratio, and core prescriptions of each age group. Results The age of onset was highest in patients aged 30-49 years. Core prescriptions for different age groups were obtained. The core prescriptions of 20-＜30 years old were stir-frying with vinegar Corydalis Rhizoma, stir-frying with vinegar Cyperi Rhizoma, Typhae Pollen, Angelicae Sinensis Radix, Chuanxiong Rhizoma, Paeoniae Radix Rubra, Paeoniae Radix Alba, stir-frying with salt Foeniculi Fructus; the core prescriptions of 30-＜40 years old were stir-frying with vinegar Cyperi Rhizoma, stir-frying with vinegar Corydalis Rhizoma, Typhae Pollen, Angelicae Sinensis Radix, Chuanxiong Rhizoma, Paeoniae Radix Alba, Leonuri Herba, Forsythiae Fructus, stir-frying with salt Foeniculi Fructus; the core prescriptions of 40-＜50 years old were stir-frying with vinegar Cyperi Rhizoma, stir-frying with vinegar Corydalis Rhizoma, Leonuri Herba, Chuanxiong Rhizoma, Paeoniae Radix Alba, Typhae Pollen, Ostreae Concha, Angelicae Sinensis Radix, Codonopsis Radix; the core prescriptions of 50-55 years old were Ostreae Concha, Typhae Pollen, Codonopsis Radix, Rehmanniae Radix, stir-frying Astragali Radix, Phellodendri Chinensis Cortex, Ecliptae Herba, stir-frying with wine Ligustri Lucidi Fructus, Anemarrhenae Rhizoma, stir-frying with vinegar Cyperi Rhizoma. Conclusion The onset age of focal AM patients tends to be younger. The treatment of focal AM should be based on activating blood circulation to dissipate blood stasis, regulating qi and relieving pain, and according to the pathogenesis differences of different age groups, with the treatment of warming interior and dispersing cold, clearing heat and detoxifying, replenishing qi and nourishing blood, tonifying kidney and nourishing yin, removing blood stasis and stopping bleeding, etc., to expand the conservative and phased treatment of the disease.

Key words： Focal adenomyosis Data mining Chinese medicine prescription Medication rule

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	DING Nan1　LIU Shuang2　SHI Wei3　LIU Zhiyong3　ZHAO Ruoxi4

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DING Nan1　LIU Shuang2　SHI Wei3　LIU Zhiyong3　ZHAO Ruoxi4. Analysis of medication rule in different age stages of focal adenomyosis based on data mining[J]. 中国医药导报, 2023, 20(14): 132-136.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.14.28 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I14/132

[1] Struble J，Reid S，Bedaiwy MA. Adenomyosis：a clinical review of a challenging gynecologic condition [J]. J Minim Invasive Gynecol，2016，23（2）：164-185.
[2] 张信美.子宫腺肌病临床表现及其分型[J].中国实用妇科与产科杂志，2019，35（5）： 498-500.
[3] Osada H. Uterine adenomyosis and adenomyoma：the surgical approach [J]. Fertil Steril，2018，109（3）：406-417.
[4] Tan J，Moriarty S，Taskin O，et al. Reproductive Outcomes after Fertility-Sparing Surgery for Focal and Diffuse Adenomyosis：A Systematic Review [J]. J Minim Invasive Gynecol，2018，25（4）：608-621.
[5] 中国医师协会妇产科医师分会子宫内膜异位症专业委员会.子宫腺肌病诊治中国专家共识[J].中华妇产科杂志，2020，55（6）：376-383.
[6] 黄卓山，罗艳婷，刘金来.真实世界研究的方法与实践[J].循证医学，2014，14（6）： 364-368.
[7] 丁楠，师伟，程文秀，等.基于数据挖掘的中医药治疗局灶性子宫腺肌病的用药规律研究[J].中药新药与临床药理，2021，32（3）：435-440.
[8] 程文秀，于航，丁楠，等.基于数据挖掘的弥漫型子宫腺肌病患者年龄分布及用药规律对比分析[J].世界科学技术-中医药现代化，2021，23（2）：560-565.
[9] 孔维莲，徐丽丽，薛燕星，等.基于复杂网络的薛伯寿教授临床处方用药规律分析研究[J].世界科学技术-中医药现代化，2017，19（1）：55-62.
[10] 谢红宁.妇产科超声诊断学[M].北京：人民卫生出版社，2015：201-202.
[11] Benagiano G， Brosens I，Habiba M. Structural and molecular features of the endomyometrium in endometriosis and adenomyosis [J]. Hum Reprod Update，2014，20（3）：386- 402.
[12] 周霞继，谢琪，刘保延，等.中医医疗与临床科研信息共享系统——《中医临床术语字典》的构建[J].中国数字医学，2016，11（1）：103-105.
[13] 国家药典委员会.中华人民共和国药典[S].一部.北京：中国医药科技出版社，2020.
[14] 于航，师伟，王怡斐，等.基于数据挖掘的中医药治疗子宫腺肌病用药规律研究[J].世界科学技术-中医药现代化，2020，22（1）：169-175.
[15] 李思彤，王昕.从肝肾论治原发性痛经探讨[J].山西中医，2022，38（4）：1-3.
[16] Riggs JC，Lim EK，Liang D，et al. Cesarean section as a risk factor for the development of adenomyosis uteri [J] J Reprod Med，2014，59（1-2）：20-24.
[17] 朱敏，段金廒，唐于平，等.当归-白芍配伍在痛经模型大鼠体内代谢产物的研究[J].中华中医药杂志，2018， 33（9）：4098-4103.
[18] 崔晨，康志媛.康志媛运用当归芍药散加味治疗子宫腺肌病经验[J].中国民间疗法，2022，30（7）：29-31.
[19] 韩晓琳，王鑫，李明，等.基于络病理论辨治子宫腺肌病[J].山东中医杂志，2021，40（6）：563-566，618.
[20] 齐丽娜，陈炫好，金华，等.中药连翘化学成分及药理活性研究进展[J].天津中医药大学学报，2021，40（2）：168-175.
[21] 李明杰，孙芮芮，李慧峰，等.益母草治疗寒凝血瘀型痛经的网络药理学作用机制研究[J].中草药，2020，51（16）：4251-4258.
[22] 应翩，邵一峰，杨华娣，等.基于数据挖掘的张萍青治疗子宫腺肌病经验[J].浙江中医药大学学报，2019，43（8）：804-809.
[23] 程文秀，丁楠，陈思儒，等.基于瘀毒理论治疗子宫腺肌病浅析[J].西部中医药，2022，35（3）：127-129.
[24] 祁君，赵葳，吴育宁.吴育宁从“痰瘀毒热互结”论治子宫腺肌病经验[J].中国医药导报，2022，19（21）：148-152.
[25] 魏竞男，王爱丽，陈彦，等.黄芪健脾益气汤治疗子宫腺肌病气虚血瘀证的临床研究[J].中医药导报，2017，23（23）：91-93.
[26] 石举梅，孙文杰，李寒宇，等.赵瑞华从肝脾肾论治围绝经期子宫内膜异位症经验[J].湖北中医药大学学报，2021，23（6）：113-116.