淋巴细胞计数、白细胞介素-6、白细胞介素-10联合检测在脓毒症早期筛查中的效能

doi:10.20047/j.issn1673-7210.2023.14.26

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Abstract Objective To evaluate the efficacy of lymphocyte count (Lym), interleukin-6 (IL-6), and interleukin-10 (IL-10) combined detection in sepsis early screening. Methods A total of 153 infected patients admitted to the First Affiliated Hospital of Chongqing Medical University from January 2021 to March 2022 were selected. Patients with Sepsis-3 were classified into sepsis group (81 cases) and non-sepsis group (72 cases). Serum Lym, IL-6, and IL-10 and other indicators were collected within 2 h after the onset of sepsis, the influencing factors of the occurrence of sepsis were analyzed, the diagnostic efficacy of Lym, IL-6, and IL-10 on sepsis was analyzed by receiver operating characteristic curve. Results Lym and lymphocyte percentage (L%) in sepsis group were lower than those in non-sepsis group, and age, IL-6, IL-10, and neutrophil count/lymphocyte count ratio were higher than those in non-sepsis group, with statistical significance (P＜0.05). Lym and L% were protective factors for sepsis (OR=0.141, 0.798, P＜0.05), IL-6 and IL-10 were risk factors for sepsis (OR=1.007, 1.080, P＜0.05). The area under the curve of Lym, IL-6, and IL-10 combined detection was higher than that of each single detection, with statistical significance (P＜0.05). Conclusion Lym, IL-6, and IL-10 are closely related to sepsis, and the combined detection of sepsis is better than that of detection alone.

Key words： Sepsis Lymphocyte count Interleukin-6 Interleukin- 10 Early diagnose

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	FU Xiaoying1　LIU Bin2　LIU Xiao1　DU Huimin3　HE Faming1　NIU Bailin1

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FU Xiaoying1　LIU Bin2　LIU Xiao1　DU Huimin3　HE Faming1　NIU Bailin1. Efficacy of lymphocyte count, interleukin-6, and interleukin-10 combined detection in sepsis early screening[J]. 中国医药导报, 2023, 20(14): 123-127.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.14.26 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I14/123

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