血清白细胞免疫球蛋白样受体亚家族B2水平在结直肠癌患者中的诊断价值

doi:10.20047/j.issn1673-7210.2023.14.22

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Abstract Objective To investigate the diagnosis value of leukocyte immunoglobulin-like receptor subfamily B2 (LILRB2) levels in patients with colorectal cancer (CRC). Methods A total of 125 CRC patients diagnosed in Affiliated Hospital of Weifang Medical University （“our hospital” for short） from January 2021 to May 2022 were selected as CRC group, and 120 patients who underwent physical examination in our hospital during the same period were selected as control group. The serum LILRB2, carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199) levels of the CRC group and control group were detected using enzyme-linked immunosorbent assay and electrochemiluminescence method, respectively. Data were statistically processed to analyze the diagnostic value of LILRB2 in patients with CRC. Results Serum LILRB2, CA199, and CEA expressions in the CRC group were higher than those in the control group, the differences were statistically significant (P＜0.05). Statistically significant differences were observed in serum LILRB2 levels among patients of different ages, lymph node metastasis, vascular tumor thrombus, depths of invasions, and TNM stages (P＜0.05). Receiver operating characteristic curve results showed, the area under curve for serum LILRB2, CA199, CEA, and combined detection of the three were 0.7593, 0.5727, 0.7234, and 0.7889, respectively. The diagnostic efficiency of the combined detection of the three was higher than that of CA199 and CEA alone, the differences were statistically significant(P＜0.05). There were no significant differences between the combined detection of the three and LILRB2 (P＞0.05). The diagnostic sensitivity of LILRB2 in TNM Ⅰ+Ⅱ patients was higher than that in TNM Ⅲ+Ⅳ patients, the differences were statistically significant (P＜0.05). Conclusion Serum LILRB2 level in CRC patients has certain clinical value in diagnosis of CRC.

Key words： Leukocyte immunoglobulin-like receptor subfamily B2 Colorectal cancer Clinicopathological features Early diagnosis

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	GENG Yan1 HUANG Yan2 WANG Zichuan1 LIU Tianzi1 PENG Xintong1 LIU Jing2

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GENG Yan1 HUANG Yan2 WANG Zichuan1 LIU Tianzi1 PENG Xintong1 LIU Jing2. Diagnosis value of serum leukocyte immunoglobulin-like receptor subfamily B2 level in the diagnosis of colorectal cancer[J]. 中国医药导报, 2023, 20(14): 102-105,127.

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