计算机游戏式认知功能训练联合丁苯酞软胶囊在血管性轻度认知障碍老年人中的应用效果

doi:10.20047/j.issn1673-7210.2023.14.15

Abstract
Figure/Table
References (37)
Related Citation (15)

Download: PDF (927 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To evaluate the effect of computer game cognitive function training combined with Butylphthalide soft Capsules in the elderly with vascular mild cognitive impairment. Methods From January 2019 to December 2020, a total of 66 elderly patients with vascular mild cognitive impairment were enrolled in outpatients from four hospitals (Liaoning Jinqiu Hospital, Liaoning Provincial People’s Hospital, the First Affiliated Hospital of China Medical University and Shengjing Hospital) in Shenyang, and demographic and clinical data were recorded. According to the random number table, they were divided into observation group and control group. The observation group was given computer adaptive gaming cognitive training combined with Butylphthalide Soft Capsules, while the control group was given single drug treatment with Butylphthalide soft capsules, with 33 cases in each group. Scores of overall cognitive function (MoCA), number span test, auditory vocabulary learning test (AVLT), connection test (STTA-STTB) and Stroop color word test were compared between the two groups before intervention, immediately after intervention and one month after intervention. Results There were significant differences of the anteriorly and backward scores of digital span test in the time, intergroup, and interaction between the two groups (P＜0.05). Further pair comparison showed that immediately after intervention, the anteriorly and backward scores of digital span test in the two groups were higher than before intervention, while those of the observation group were higher than those of the control group; the number span test score of the observation group was higher than that of the control group one month after intervention, and the differences were statistically significant (P＜0.05). There were statistically significant differences of AVLT recognition in scoring of the anteriorly and backward scores of digital span test time, inter-group and interaction between the two groups (P＜0.05). The total time of AVLF immediate memory between the two groups was statistically significant (P＜0.05). Further pairwise comparison showed that the total scores of AVLF recognition and immediate memory in the two groups were higher immediately after intervention than before intervention; one month after the intervention, the AVLT scores of the observation group were higher than those before the intervention, and the differences were statistically significant (P＜0.05). The comparison of STT-A between the two groups was statistically significant (P＜0.05). Comparison of STT-B in time, intergroup, and interaction between the two groups showed statistically significant differences (P＜0.05). Further pair-to-pair comparison showed that STT-A in the observation group was lower than that in the control group at the same time point immediately after intervention and a month after intervention; immediately after intervention, STT-B in both groups was lower than before intervention, and the observation group was lower than the control group; one month after the intervention, STT-B in the observation group was lower than before intervention, and lower than that in the control group, the differences were statistically significant (P＜0.05). The comparison of StroopA in time and interaction between the two groups were statistically significant (P＜0.05). The comprison of StroopB in time, intergroup and interaction between the two groups were statistically significant (P＜0.05). Further pair comparison showed: immediately after intervention, StroopA in both groups was lower than before intervention; one month after intervention, StroopA in observation group was lower than before intervention, and lower than control group, the differences were statistically significant (P＜0.05). Immediately after intervention, StroopB in the two groups was lower than before intervention, and the observation group was lower than the control group; one month after intervention, StroopA in the observation group was lower than before intervention and lower than the control group, with statistical significance (P＜0.05). There were statistically significant differences of total MoCA in time, intergroup, and interaction between the two groups (P＜0.05). Further pair comparison showed that the total score of MoCA of cognitive function in the observation group was higher than that before intervention and was higher than that in the control group after intervention, and the differences were statistically significant (P＜0.05). Conclusion The application of computer game cognitive function training combined with Butylphthalide Soft Capsules therapy in the elderly with vascular mild cognitive impairment has a significant effect, which can effectively improve the cognitive dysfunction and improve the quality of life of patients.

Key words： Mild vascular cognitive impairment Butylphthalide Soft Capsules Computer cognitive training Cognitive function assessment

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Wei LI Yaning

Cite this article:

ZHANG Wei LI Yaning. Application effect of computer game cognitive function training combined with Butylphthalide Soft Capsules in elderly with vascular mild cognitive impairment[J]. 中国医药导报, 2023, 20(14): 70-75,85.

URL:

https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.14.15 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I14/70

[1] 贾建平，陈生弟.神经病学[M].8版.北京：人民卫生出版社，2019：4.
[2] 余波，张晓玲，官俏兵，等.血管性痴呆和阿尔茨海默病的认知功能及精神行为比较[J].中华全科医学，2015，13（7）：1204-1205.
[3] 欧春影，李传玲.血管性痴呆相关危险因素及其机制的研究新进展[J].中华临床医师杂志，2016，10（2）：248-251.
[4] Valenzuela M，Sachdev P. Can cognitive exercise prevent the onset of dementia? Systematic review of randomized clinical trials with longitudinal follow-up [J]. Am J Geriatr Psychiatry，2009，17（3）：179-187.
[5] Kalaria RN. Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease [J]. Acta Neuropathol，2016，131（5）：659-685.
[6] 王玲芝，郭耀光，沈峰.计算机认知矫正训练治疗强迫症的临床初探[J].中国临床心理学杂志，2014，22（4）：749，751.
[7] Liang J，Xu Y，Lin L，et al. Comparison of multiple interventions for older adults with Alzheimer disease or mild cognitive impairment [J]. Medicine，2018，97（20）：1-13.
[8] Nicole TM，Hill M，Loren M，et al. Computerized cognitive training in older adults with mild cognitive impairment or dementia：a systematic review and meta-analysis [J]. Am J Psychiatry，2017，174（4）：329-340.
[9] 胡艳群，张立力，钟薇，等.自适应认知训练对非痴呆型血管性认知障碍患者认知能力和生活质量的影响[J].海南医学，2017，28（16）：2624-2627.
[10] Jacko J，Emery VK，Edwards PJ，et al. The effects of multimodal feedback on older adults’ task performance given varying levels of computer experience [J]. Behav Inf Technol，2004，23（4）： 247-264.
[11] Lampit A，Hallock H，Valenzuela M，et al. Computerized Cognitive Training in Cognitively Healthy Older Adults：A Systematic Review and Meta-Analysis of Effect Modifiers [J]. PLoS Med，2014，11（11）：e1001756.
[12] 廖艳彪.丁基苯酞对血管性痴呆的认知功能的影响[J].医学综述，2014，20（18）：3343-3345.
[13] 王恒敏.多奈哌齐联合丁苯肽对血管性痴呆患者认知功能和情感障碍的影响研究[J].河北医学，2017，23（3）：460-463.
[14] 陈世振，陈康亮，范煜华，等.认知功能训练联合脑循环治疗对轻度血管性痴呆的疗效[J].国际老年学杂志，2020， 41（2）：76-79.
[15] 国家卫生健康委办公厅.血管性认知障碍的诊疗规范（2020）年版[J].全科医学临床与教育，2021，19（3）：197- 199.
[16] 王娟，陈秀，等.中文版MoCA和MoCA-B在遗忘型轻度认知功能障碍中的应用[J].四川医学，2018，39（7）：783- 786.
[17] 藤召军，张富洪，罗情玲.注意与记忆广度信息储存实验研究[J].信息通信，2011，2：46-47.
[18] 郭起浩，洪震.神经心理评估[M].上海：上海科学技术出版社，2013：101-102.
[19] Sanchez-Cubillo I，Perianez JA，Adrover Roig D，et al. Con- struct validity of the Trail Making Test：role of tasks witching，working memory，inhibition/interfereence control，and visuomotor abilities [J]. J Int Neuropsychol Soc，2009， 15（3）：438-450.
[20] Misdraji EL，Gass CS. The Trail Making Test and its neurobehavioral components [J]. J Clin Exp Neuropsychol，2010， 32（2）：159-163.
[21] 贾阳娟，韩凝，王美蓉，等.MoCA与MMSE 在急性缺血性卒中后认知障碍评估中的应用[J]中华行为医学与脑科学杂志，2017，26（1）：46-50.
[22] 汤德生，叶新，王瑛，等.数字广度短时记忆计算机测试法信度及效度的临床初步研究[J].中国行为医学科学，1998（2）：97-99.
[23] 贾建平，李妍.中国痴呆的现状和未来[J].中华神经科杂志，2020，53（2）：81-84
[24] Rasquin SM，Lodder J，Ponds RW，et al. Cognitive functioning after stroke：a non-year follow-up study [J]. Dement Geriatr Cogn Disord，2004，18：138-144.
[25] Itchie K，Touchon J. Mild cognitive impairment：conceptual basis and current nosological status [J]. Lancet，2000，355：225-228.
[26] 朱宏霞，张彩华.老年人群轻度认知功能障碍的调查与分析[J].上海护理，2009，9（3）：45-48.
[27] 陈雯洁.老年人认知功能损害的危险因素[J].中华老年多器官疾病杂志，2005，4（2）：1467-1469.
[28] 柏燕燕，孔玉，周国庆，等.丁苯酞对轻度血管性认知障碍患者执行功能的影响[J].中国卒中杂志，2019，4（1）：28-31.
[29] Wilson RS，Barnes LL，Aggarwal NT，et al. Cognitive activity and the cognitive morbidity of Alzheimer disease [J]. Neurology，2010，75（11）：990-996.
[30] Corral M，Rodríguez M，Amenedo E，et al. Cognitive reserve，age，and neuropsychological performance in healthy participants [J]. Dev Neuropsychol，2006，29（3）：479-491.
[31] Park DC，Bischof GN. The aging mind： neuroplasticity in response to cognitive training [J]. Dialogues Clin Neurosci，2013，15（1）：109.
[32] Mahncke HW，Connor BB，Appelman J，et al. Memory enhancement in healthy older adults using a brain plasticity-based training program：A randomized，controlled study [J]. Proc Natl Acad Sc U S A，2006，103（33）：12523-8.
[33] 中国老年医学学会认知障碍分会，认知障碍患者照料及管理专家共识撰写组.中国认知障碍患者照料管理专家共识[J].中华老年医学杂志，2016，35（10）：1051-1060.
[34] 韩晔，刘敏，周盛年，等.计算机辅助认知康复训练治疗脑梗死后执行功能障碍的疗效观察[J].中华物理医学与康复杂志，2018，40（7）：544-546.
[35] 张孙鑫，何永生.计算机辅助认知康复训练治疗创伤性脑损伤后认知功能障碍的研究进展[J].中华神经医学杂志，2019，18（1）：98-101.
[36] 姜财，杨珊莉，黄佳，等.计算机辅助认知训练对脑卒中患者认知功能恢复的影响及其机制的fMRI研究[J].中国康复医学杂志，2015，30（9）：911-914.
[37] 朱婉茸，张扶莉，许韬，等.血管性痴呆患者采用不同治疗方法对其认知功能影响分析[J].国际精神病学杂志，2015（2）：56-59.