|
|
|
| Research progress on the mechanism of circular RNA in virus replication |
| BI Wanying1 WANG Wanping1 LONG Yongwen1 TANG Shifu2▲ |
1.Graduate School, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530299, China;
2.Liuzhou Key Laboratory of Precision Medicine for Viral Diseases, Guangxi Zhuang Autonomous Region, Liuzhou 545026, China
|
|
|
|
Abstract Virus replication is the key node for virus to survive and reproduce in the host, which is very harmful to human health. Humoral immunity and cellular immunity are the main means for the body to regulate virus replication. However, due to the complexity and diversity of the human immune system, most of the mechanisms of virus replication are still unclear. Circular RNA is a kind of non coding RNA with the function of gene expression regulation. It regulates viral replication by regulating immune response factors, miRNA, proteins, replication starting points, DNA synthesis and assembly, and other processes. Although there are problems such as low expression of circular RNA and high cost of sequencing and library building, circular RNA is still a good method to explain the mechanism of virus replication.
|
|
|
|
|
|
[1] Liang Y，Liu N，Yang L，et al. A Brief Review of circRNA Biogenesis，Detection，and Function [J]. Curr Genomics，2021， 22（7）：485-495.
[2] 武世萍，俞坤，王满侠.环状RNA的生物学功能及其与中枢神经系统疾病关系的研究进展[J].中国生物制品学杂志，2022，35（3）：356-362.
[3] 徐彩鹏，陈小花，赵大鹏，等.环状RNA及其在肿瘤中的作用[J].生理科学进展，2022，53（1）：39-44.
[4] 薛拴勤，朱洁，陈丽君，等.环状RNA在心血管疾病发病机制中的研究进展[J].中华老年多器官疾病杂志，2022， 21（5）：379-384.
[5] Kristensen LS，Andersen MS，Stagsted LVW，et al. The biogenesis，biology and characterization of circular RNAs [J]. Nat Rev Genet，2019，20（11）：675-691.
[6] Chen LL. The expanding regulatory mechanisms and cellular functions of circular RNAs [J]. Nat Rev Mol Cell Biol，2020， 21（8）：475-490.
[7] Huang A，Zheng H，Wu Z，et al. Circular RNA-protein interactions：functions，mechanisms，and identification [J]. Theranostics，2020，10（8）：3503-3517.
[8] Li J，Hu Z，Yu S，et al. CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma [J]. Cancer Res，2022，82（6）：1055-1069.
[9] Chen Y，Li S，Wei Y，et al. Circ-RNF13，as an oncogene，regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2 [J]. Bosn J Basic Med Sci，2021，21（5）：555-568.
[10] Wang ZY，Guo ZD，Li JM，et al. Genome-Wide Search for Competing Endogenous RNAs Responsible for the Effects Induced by Ebola Virus Replication and Transcription Using a trVLP System [J]. Front Cell Infect Microbiol，2017， 7：479.
[11] Yan L，Chen YG. Circular RNAs in Immune Response and Viral Infection [J]. Trends Biochem Sci，2020，45（12）：1022-1034.
[12] Tagawa T，Gao S，Koparde VN，et al. Discovery of Kaposi’s sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA [J]. Proc Natl Acad Sci U S A，2018， 115（50）：12805-12810.
[13] Shi N，Zhang S，Guo Y，et al. CircRNA_0050463 promotes influenza A virus replication by sponging miR-33b-5p to regulate EEF1A1 [J]. Vet Microbiol，2021，254：108995.
[14] Zhang L，Wang Z. Circular RNA hsa_circ_0004812 impairs IFN-induced immune response by sponging miR-1287-5p to regulate FSTL1 in chronic hepatitis B [J]. Virol J，2020， 17（1）：40.
[15] Du N，Li K，Wang Y，et al. CircRNA circBACH1 facilitates hepatitis B virus replication and hepatoma development by regulating the miR-200a-3p/MAP3K2 axis [J]. Histol Hist- opathol，2022，37（9）：863-877.
[16] 潘劲辉.RSV感染引起的circRNA的鉴定分析及环状RNA对RSV感染的影响研究[D].广东：广州医科大学，2019.
[17] Chen TC，Tallo-Parra M，Cao QM，et al. Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells [J]. PLoS Pathog，2020，16（8）：e1008346.
[18] Yu T，Ding Y，Zhang Y，et al. Circular RNA GATAD2A promotes H1N1 replication through inhibiting autophagy [J]. Vet Microbiol，2019，231：238-245.
[19] Deng J，Huang Y，Wang Q，et al. Human Cytomegalovirus Influences Host circRNA Transcriptions during Productive Infection [J]. Virol Sin，2021，36（2）：241-253.
[20] Liu Q，Shuai M，Xia Y. Knockdown of EBV-encoded circRNA circRPMS1 suppresses nasopharyngeal carcinoma cell proliferation and metastasis through sponging multiple miRNAs [J]. Cancer Manag Res，2019，11：8023-8031.
[21] Abere B，Zhou H，Li J，et al. Merkel Cell Polyomavirus Encodes Circular RNAs （circRNAs） Enabling a Dynamic circRNA/microRNA/mRNA Regulatory Network [J]. mBio，2020，11（6）：e03059-03020.
[22] Arora S，Singh P，Dohare R，et al. Unravelling host-pathogen interactions：ceRNA network in SARS-CoV-2 infection （COVID-19） [J]. Gene，2020，762：145057.
[23] 梁子.HBV起源的circRNA HBV_circ_1的形成机制及功能研究[D]. 苏州：苏州大学，2020.
[24] Sekiba K，Otsuka M，Funato K，et al. HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA [J]. J Hepatol，2022， 76（1）：53-62.
[25] Zhao J，Lee EE，Kim J，et al. Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus [J]. Nat Commun，2019，10（1）：2300.
[26] 曾昭萍.第一部分+缅甸输入性Ⅰ型和Ⅱ型登革病毒的全基因组序列测定和分子特征分析；第二部分+多瘤病毒SV40来[D].北京：中国医学科学院北京协和医学院，2019.
[27] Ungerleider N，Concha M，Lin Z，et al. The Epstein Barr virus circRNAome [J]. PLoS Pathog，2018，14（8）：e1007206.
[28] Ungerleider NA， Jain V，Wang Y，et al. Comparative analysis of gammaherpesvirus circRNA repertoires：conserved and unique viral circular RNAs [J]. J Virol，2019，93（6）：e01952-01918.
[29] Tan KE，Lim YY. Viruses join the circular RNA world [J]. FEBS J，2021，288（15）：4488-4502.
[30] Abere B，Li J，Zhou H，et al. Kaposi’s Sarcoma-Associated Herpesvirus-Encoded circRNAs Are Expressed in Infected Tumor Tissues and Are Incorporated into Virions [J]. mBio，2020，11（1）：e03027-03019.
[31] Yang S，Liu X，Wang M，et al. Circular RNAs Represent a Novel Class of Human Cytomegalovirus Transcripts [J]. Microbiol Spectr，2022，10（3）：e0110622. |
|
|
|
