自噬与念珠菌致病及耐药的相关性

doi:10.20047/j.issn1673-7210.2023.14.09

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Abstract Autophagy is an inherent degradation metabolic pathway of eukaryotic cells. It is involved in biological processes such as organelle degradation, nutrient balance, and programmed death to regulate the morphological transformation and cell differentiation required for the key links of fungal infection. Moderate autophagy protects fungi against a poor living environment, and an imbalance of autophagy leads to autophagic cell death. Candida is the leading pathogen causing invasive fungal infections in hospitalized patients. Autophagy plays an important role in regulating the pathogenicity and drug resistance of Candida. Therefore, this paper aims to review the molecular mechanism of autophagy and the research status of autophagy in Candida, in order to provide new ideas for the prevention-treatment strategies of Candida and the research and development of antifungal drugs.

Key words： Candida Drug resistance Autophagy Selective autophagy

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	LI Zhen　CHEN Weiqin

Cite this article:

LI Zhen　CHEN Weiqin. Correlation between autophagy and Candida pathogenicity and drug resistance[J]. 中国医药导报, 2023, 20(14): 43-46,51.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.14.09 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I14/43

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