G蛋白信号转导调节蛋白10在肾透明细胞癌中的表达及临床意义

doi:10.20047/j.issn1673-7210.2023.14.04

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Abstract Objective To investigate the expression and clinical significance of regulator of G-protein signaling 10 (RGS10) gene in renal clear cell carcinoma. Methods The transcriptome data of renal clear cell carcinoma were downloaded from the cancer genome atlas database. The differential expression and clinical significance of RGS10 gene in renal clear cell carcinoma was analyzed. Using the median RGS10 gene expression as the dividing line, 266 cases were divided into low expression group (RGS10≤8.776) and 266 cases were divided into high expression group (RGS10 > 8.776). Kaplan-Meier method was used to analyze the relationship between RGS10 expression and survival prognosis in patients with renal clear cell carcinoma. Multivariate Cox regression was used to analyze the prognostic factors of patients with renal clear cell carcinoma. The receiver operating characteristic（ROC） curve was used to analyze the predictive value, and the relevant signaling pathways regulated by RGS10 were identified by gene enrichment analysis. Results The expression of RGS10 gene in renal clear cell carcinoma tissues was higher than that in adjacent tissues (P＜0.001). ROC curve results showed that the area under the curve of RGS10 expression in predicting renal clear cell carcinoma was 0.920, 95%CI was 0.896-0.940, the specificity was 90.3%, and the sensitivity was 85.4% (P＜0.001). The expression of RGS10 was correlated with gender, pathological grade, T stage, N stage, M stage， and clinical stage of patients with renal clear cell carcinoma (P＜0.01). Kaplan-Meier survival curve suggested that the overall survival prognosis of the high expression group was worse than that of the low expression group (P＜ 0.001). Univariate analysis showed that age, tumor location, pathological grade, clinical stage, T stage, N stage, M stage, and RGS10 expression level were correlated with the survival of patients with renal clear cell carcinoma (P＜0.05). Multivariate Cox regression analysis showed that patients’ age (HR=1.756, 95%CI: 1.148-2.686), M stage (HR=2.727, 95%CI: 1.595-4.660) and RGS10 expression level (HR=1.834, 95%CI: 1.148-2.930) were independent prognostic factors of patients with renal clear cell carcinoma (P＜0.05). Gene enrichment analysis showed that the function of RGS10 was mainly concentrated in Toll-like receptor signaling pathway, FcγR-mediated phagocytosis signaling pathway, and B cell receptor signaling pathway. Conclusion RGS10 is a potential diagnostic and prognostic molecular marker for renal clear cell carcinoma. In renal clear cell carcinoma, Toll-like receptor signaling pathway, FcγR-mediated phagocytosis signaling pathway, and B cell receptor signaling pathway may be regulated by RGS10 gene.

Key words： Regulator of G-protein signaling 10 Renal clear cell carcinoma The cancer genome atlas Prognosis

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	XIE Zhibin1　XIE Guangyu1　FENG Yaoning1 LIAO Xuemei1 DING Qijian1　FU Weijin2

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XIE Zhibin1　XIE Guangyu1　FENG Yaoning1 LIAO Xuemei1 DING Qijian1　FU Weijin2. Expression and clinical significance of regulator of G-protein signaling 10 in renal clear cell carcinoma[J]. 中国医药导报, 2023, 20(14): 20-24.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.14.04 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I14/20

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