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| Effects of Esomeprazole combined with Shugan Hewei Anshen Prescription on sleep quality and gastrointestinal hormones in patients with refractory gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach |
| SHEN Ding1 YE Wei2▲ |
1.The Third Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang Province, Hangzhou 310007, China;
2.Department of Gastroenterology, Hangzhou Traditional Chinese Medicine Hospital Affiliated to the Zhejiang Chinese Medical University, Zhejiang Province, Hangzhou 310007, China
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Abstract Objective To investigate the effects of Esomeprazole combined with Shugan Hewei Anshen Prescription on sleep quality and gastrointestinal hormone in patients with refractory gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach. Methods A total of 120 patients receiving treatment for refractory gastroesophageal reflux disease in Hangzhou Traditional Chinese Medicine Hospital Affiliated to the Zhejiang Chinese Medical University from June 2021 to June 2022 were selected and divided into traditional Chinese medicine group, western medicine group, and combined group according to random number table method, with 40 cases in each group. The traditional Chinese medicine group was given Shugan Hewei Anshen Prescription; the western group was given Esomeprazole; the combination group was given Esomeprazole combined with Shugan Hewei Anshen Prescription, and the three groups were treated for eight weeks. The traditional Chinese medicine syndrome score level was evaluated, the scavenging time, acid reflux times, post-reflux swallow-induced peristaltic wave (PSPW) index, and the levels of motilin (MTL), gastrin (GAS), and vasoactive intestinal peptide (VIP) were detected. The Pitts-burgh sleep quality index (PSQI) was used to assess sleep quality. Results After treatment, the acid reflux score, the retrosternal burning pain score, the irritability score, the two-side swelling score, the scavenging time of food mass, the acid reflux times, the PSPW index level, the VIP level, and the PSQI score of the three groups were lower than those before treatment, and the combined group was lower than the traditional Chinese medicine group and the western medicine group, and the differences were statistically significant (P＜0.05). After treatment, the MTL and GAS levels in the three groups were higher than those before treatment, and the combined group was higher than the traditional Chinese medicine group and western medicine group, and the differences were statistically significant (P＜0.05). Conclusion After combined treatment with Espromepazole, Shugan Hewei Anshen Prescription, traditional Chinese medicine syndrome integral level of patients with refractory gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach can be reduced, esophageal dynamic function can be restored, gastrointestinal hormone levels can be improved and sleep quality can be improved.
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[1] Yadlapati R，DeLay K. Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease [J]. Med Clin North Am，2019，103（1）：15-27.
[2] Spechler SJ. Refractory Gastroesophageal Reflux Disease and Functional Heartburn [J]. Gastrointest Endosc Clin N Am，2020，30（2）：343-359.
[3] Chapelle N，Ben Ghezala I，Barkun A，et al. The pharmacotherapeutic management of gastroesophageal reflux disease （GERD）[J]. Expert Opin Pharmacother，2021，22（2）：219- 227.
[4] 尹波南.疏肝和胃化瘀安神汤治疗胃病不寐25例[J].特别健康，2020（9）：97-98.
[5] 牛美娜，王海翠，朱双双，等.双倍剂量艾司奥美拉唑、莫沙必利联合坦度螺酮治疗难治性胃食管反流病的疗效[J].实用医学杂志，2022，38（1）：90-95.
[6] 中华医学会消化病学分会.2014年中国胃食管反流病专家共识意见[J].胃肠病学，2015，20（3）：155-168.
[7] 白兴华.对《胃食管反流病中医诊疗专家共识意见（2017）》的思考[J].上海中医药杂志，2019，53（11）：5-10.
[8] 孙恺蒂，马双，惠洋洋，等.质子泵抑制剂对胃食管反流病夜间反流症状的疗效——华北地区数据分析[J].胃肠病学，2021，26（6）：325-331.
[9] 徐泳茵，吴皓萌，秦书敏，等.不同地域中医名家论治胃食管反流病的学术特点比较[J].世界中医药，2022，17（15）：2117-2120.
[10] 吕伟伟.疏肝和胃化瘀安神汤治疗胃病不寐临床疗效研究[J].中国农村卫生，2021，13（7）：62-63.
[11] 何婧，王毅，周竞，等.艾司奥美拉唑联合穴位针灸治疗中虚气逆型胃食管反流病的临床观察[J].世界中西医结合杂志，2021，16（6）：1079-1083，1088.
[12] 郭正明.疏肝和胃化瘀安神汤对胃病不寐疾病的治疗效果[J].中外女性健康研究，2018（23）：82-83.
[13] 王亮，王鹏，侯晓圆，等.和胃安神方治疗失眠的网络药理学和分子对接机制研究[J].世界中医药，2022，17（5）：671-677.
[14] 应笑，李蒙，金超琼，等.基于里昂共识比较胃食管反流病与食管功能性疾病的食管动力学差异[J].中华消化杂志，2020，40（2）：87-92.
[15] 郭凡菱，黄红英，陈晋超，等.双歧杆菌治疗质子泵抑制剂致老年胃食管反流病患者肠道菌群紊乱的效果及对胃肠激素的影响[J].中国临床保健杂志，2020，23（6）：815-819.
[16] 刘鹤婷，尚占民，黄皖农，等.马来酸曲美布汀对伴有无效食管动力的胃食管反流病患者食管运动功能的影响[J].临床消化病杂志，2016，28（3）：170-174.
[17] 朱淑云，瞿兵，谭远忠.丹栀逍遥散合左金丸加减治疗肝胃郁热型胃食管反流病的疗效以及对胃肠激素水平的影响[J].辽宁中医杂志，2021，48（4）：92-95.
[18] 郑洪伟.兰索拉唑辅助莫沙必利治疗胃食管反流病对胃肠功能、胃食管动力学的影响分析[J].中国现代药物应用，2020，14（4）：140-141.
[19] 郭虹，杨翠红，刘晓敏，等.胃食管反流病合并抑郁患者食管动力与pH值表现及意义[J].广东医学，2022，43（4）：503-506.
[20] 唐丽明，宋宁，熊鹰，等.旋覆代赭汤加味治疗肝胃不和型难治性胃食管反流病的临床疗效及对胃肠激素的影响[J].辽宁中医杂志，2020，47（11）：109-112.
[21] 穆恒，于勇.小柴胡降逆汤联合天突穴针刺对胃食管反流病相关性支气管哮喘患者胃肠激素、食管动力学和生活质量的影响[J].现代中西医结合杂志，2021，30（8）：843-847，888.
[22] 张啸，周晓虹.周晓虹教授运用疏肝和胃法治疗非糜烂性反流病经验浅谈[J].西部中医药，2021，34（11）：83- 86.
[23] 梁效铭.疏肝和胃方合左金丸加减治疗肝胃郁热型胃食管反流病的疗效及对胃肠激素水平的影响[J].中国医药科学，2022，12（5）：197-200.
[24] 张海芳，陈俊红，张娟，等.氟哌噻吨美利曲辛辅助治疗胃食管反流病伴睡眠障碍患者的效果分析[J].医学理论与实践，2021，34（9）：1506-1508.
[25] 马龙，张蕊荣.氟哌噻吨美利曲辛片联合兰索拉唑、伊托必利治疗难治性胃食管反流病的临床效果[J].临床医学研究与实践，2021，6（24）：57-59.
[26] 陈川铁，曾小辉.艾司奥美拉唑联合马来酸曲美布汀治疗老年性胃食管反流病的效果[J].中国当代医药，2022， 29（3）：71-73，77.
[27] 翟昂帅，曲娟.气滞胃痛颗粒对非糜烂性胃食管反流病患者焦虑抑郁情绪及睡眠质量的影响[J].继续医学教育，2021，35（11）：159-162. |
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