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| Clinical effect of Somalutide on patients with type 2 diabetes mellitus |
| WANG Mengying1 ZHANG Hecheng1 WANG Fang1 YE Qibao2 |
1.Department of Endocrinology, Suzhou Hospital Affiliated to Anhui Medical University, Anhui Province, Suzhou 234000, China;
2.Department of Endocrinology, Binhu District, Hefei First People’s Hospital, Anhui Province, Hefei 233000, China
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Abstract Objective To explore the clinical effect of Somalutide on patients with type 2 diabetes mellitus (T2DM). Methods A total of 160 patients with T2DM admitted to Suzhou Hospital Affiliated to Anhui Medical University from January 2019 to December 2021 were selected, and they were divided into observation group and control group by random number table method, with 80 cases in each group. The control group was treated with Metformin orally, the observation group was treated with Somarlutide based on the control group. The treatment cycle of the two groups was three months. Body mass index (BMI), blood glucose indexes (fasting blood glucose [FBG], 2-hour postprandial blood glucose [2hPBG], glycosylated hemoglobin [HbAlc]), blood lipid indexes (total cholesterol [TC], triglyceride [TG], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C]), and serum inflammatory index (the levels of hypersensitive C-reactive protein [hs-CRP], tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6] ) were compared between the two groups before and after treatment, and the incidence of adverse reactions were compared between the two groups. The incidence of adverse reactions was compared between the two groups. Results After treatment, BMI and blood glucose levels in the two groups were lower than before treatment, and the observation group was lower than the control group, the differences were statistically significant (P＜0.05). After treatment, TG, TC and LDL-C in two groups were lower than before treatment, and HDL-C was higher than before treatment. TG, TC and LDL-C in observation group were lower than control group, and HDL-C was higher than control group, the differences were statistically significant (P＜0.05). After treatment, the levels of inflammatory factors in the two groups were lower than before treatment and the observation group was lower than the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Somaluptide is more effective in the treatment of T2DM. It can effectively improve blood glucose, blood lipid and inflammatory indicators, reduce the weight of patients without obvious adverse reactions. It is recommended for clinical application.
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