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Effect of evidence-based preventive nursing on patients with primary tumor immunotherapy |
ZHAO Lei WANG Xianzhen MA Lingyun |
Department of Oncology, Huaibei People’s Hospital, Anhui Province, Huaibei 235000, China
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Abstract Objective To explore the effect of evidence-based preventive nursing on primary tumor immunotherapy patients. Methods A total of 83 patients with primary tumor who received immunotherapy in Huaibei People’s Hospital of Anhui Province from January 2019 to June 2022 were selected, the patients were divided into routine group (41 cases) and intervention group (42 cases) by random number table method. The routine group received routine nursing intervention, and the intervention group received evidence-based preventive nursing on the basis of the routine group. The compliance, nutritional status, and the occurrence of adverse reactions between the two groups were observed and compared. Results After intervention, the compliance of intervention group was higher than that of conventional group, and the difference was statistically significant (P<0.05); the scores of hemoglobin, serum albumin, and subjective comprehensive nutrition assessment in the two groups were higher than those of before intervention, and the intervention group was higher than the routine group, and the differences were statistically significant (P<0.05); the incidence of adverse reactions in the intervention group was lower than that in the routine group, and the difference was statistically significant (P<0.05). Conclusion Evidence-based preventive nursing can improve the compliance and nutritional status of patients with primary liver cancer undergoing immunotherapy, and improve the safety of immunotherapy.
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[1] 丁继平,李晓光,刘忠龙,等.救治性手术联合放疗与化疗序贯免疫检查点抑制剂治疗复发转移舌鳞癌1例报道[J].上海交通大学学报(医学版),2021,41(12):1704- 1708.
[2] 陈锦,张彩.嵌合抗原受体修饰的免疫细胞及其在肿瘤免疫治疗中的应用[J].中国肿瘤生物治疗杂志,2021,28(6):549-557.
[3] 本刊编辑部.《中国肿瘤临床》文章荐读:免疫检查点抑制剂治疗肿瘤的不良反应及管理策略[J].中国肿瘤临床,2019,46(15):803.
[4] 聂芳芳,付杰.肿瘤免疫检查点抑制剂治疗不良反应及其治疗—皮肤[J].中华放射肿瘤学杂志,2018,27(3):331- 334.
[5] 孙御芳,倪中亚,王莉新,等.基于NK细胞的肿瘤免疫逃逸及中医药对NK的免疫调节作用[J].中国医药导报,2019, 16(28):52-55.
[6] 李中晨,任正刚.免疫检查点抑制剂治疗肝细胞癌相关不良反应及管理[J].中华肝脏病杂志,2021,29(6):600- 603.
[7] 赵艺媛,张彬,陆宇晗,等.头颈部恶性肿瘤住院患者术前营养风险筛查的循证护理实践[J].中国护理管理,2018, 18(12):1613-1617.
[8] 周际昌.实用肿瘤内科学[M].2版.北京:人民卫生出版社,1999:587.
[9] 张颖慧,杨雪,张笛,等.主观综合性评估乙型肝炎性肝硬化病人的营养状况[J].肠外与肠内营养,2016,23(6):329-331.
[10] Nochaiwong S,Ruengorn C,Koyratkoson K,et al. Clinical interpretation of the Uremic Pruritus in Dialysis Patients (UP-Dial) scale:a novel instrument for the assessment of uremic pruritus [J]. Eur Acad Dermatol Venereol,2018,32(7):1188-1194.
[11] Bader JE,Voss K,Rathmell JC. Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy [J]. Mol Cell,2020,78(6):1019-1033.
[12] 梁巧妍,于敏.肿瘤微环境内代谢变化与肿瘤免疫治疗研究[J].中国肿瘤,2021,30(6):459-464.
[13] 杨雅凝,杨路,王燕.肺癌免疫治疗耐药机制及应对策略[J].中国肺癌杂志,2021,24(2):112-123.
[14] 乔天运,郭文文,熊延路,等.肿瘤免疫治疗联合化疗的理论基础及临床应用[J].现代肿瘤医学,2021,29(17):3128-3132.
[15] 王志高,方祁琪,高飞,等.肿瘤整合治疗中免疫联合治疗的机制与策略[J].肿瘤防治研究,2020,47(11):811- 816.
[16] 孟雨,白玉贤.肿瘤免疫治疗引起的常见免疫不良事件及相关问题总结分析[J].现代肿瘤医学,2022,30(18):3418-3422.
[17] 王雪竹,王静楠,胡桂兰,等.18F-FDG PET/CT在探查肝胆恶性肿瘤免疫联合治疗中免疫相关不良反应的应用价值[J].中华核医学与分子影像杂志,2022,42(6):352- 356.
[18] 白日兰,崔久嵬.免疫检查点抑制剂治疗相关不良反应—新探索、新挑战[J].中国肿瘤生物治疗杂志,2021, 28(5):419-430.
[19] 李海燕,王金萍,植艳茹,等.静脉血栓栓塞症预防循证护理方案在骨科住院患者中的应用[J].解放军护理杂志,2021,38(1):57-60.
[20] 张伟,朱宁宁,雷婷婷,等.胃癌患者术后肠内营养喂养不足循证预防护理方案构建[J].护理学杂志,2018,33(11):1-4.
[21] 苏春霞,周彩存.晚期非小细胞肺癌免疫治疗现状及未来方向[J].中国癌症杂志,2022,32(6):478-486.
[22] 刘玉霞,张彩.γδT细胞对肿瘤发生、发展的影响及其在肿瘤免疫治疗中的应用[J].中国免疫学杂志,2021, 37(13):1637-1642.
[23] 卢大松,冯勇军,王武峰,等.个体化营养干预对局部晚期鼻咽癌患者生活质量及生存预后的影响[J].中国癌症杂志,2021,31(12):1202-1208.
[24] 姚望,张鑫杰,姚庆华.胃肠道恶性肿瘤化疗患者早期肠内营养干预的临床研究[J].中国肿瘤临床,2019,46(15):780-784.
[25] 周毅,孙建国.肿瘤免疫治疗引起免疫相关不良反应的若干思考[J].医药导报,2019,38(8):1003-1007. |
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