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Distribution and drug resistance monitoring of pathogenic bacteria in urine culture of Xiyuan Hospital, China Academy of Chinese Medical Sciences from 2019 to 2021 |
WANG Zhong WANG Qingyong GAO Qinghe SHAO Kuiqing CHEN Haote WANG Xiong ZHOU Yanyan GAO Zhan |
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
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Abstract Objective To investigate the distribution of pathogenic bacteria of urinary tract infection in Xiyuan Hospital, China Academy of Chinese Medical Sciences and analyze the drug resistance of different pathogenic bacteria. Methods Urine culture samples were collected from patients with urinary tract infection in Xiyuan Hospital, China Academy of Chinese Medical Sciences from January 2019 to December 2021. The isolated strains were identified by MALDI-TOF MS, and the BD PheniX-100 automatic bacterial identification drug sensitivity system was used to determine the minimum inhibitory concentration. WHONET 5.6 was used for drug susceptibility data statistics, and SPSS 25.0 was used for data analysis. Results A total of 1 191 strains of urinary tract infection pathogens were obtained. The main Gram-negative bacteria were Escherichia coli and Klebsiella pneumoniae. The main Gram-positive bacteria were Enterococcus faecalis and Streptococcus agalactiae. There was no significant difference in the sensitivity rate of extended-spectrum β-lactamases (ESBLs)-producing and non-ESBLs-producing Escherichia coli to gentamicin (P>0.05). The sensitivity rate of ESBL-producing Escherichia coli to other commonly used drugs was lower than that of non-ESBL-producing Escherichia coli (P<0.05). Conclusion The detection rate of ESBLs and drug-resistant strains in Escherichia coli and Klebsiella pneumoniae is high. Enterococcus faecalis is also resistant to commonly used drugs. We should strengthen the monitoring of bacterial resistance in hospitals and use antibiotics rationally.
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