益气扶正消积方辅助化疗对气滞血瘀型晚期肺癌患者生活质量及副作用的影响

doi:10.20047/j.issn1673-7210.2023.10.24

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Abstract Objective To investigate the influence of supplementing chemotherapy with Yiqi Fuzheng Xiaoji Formula on the quality of life and side effects in advanced lung cancer patients with syndrome of qi stagnation and blood stasis. Methods A total of 120 advanced lung cancer patients with syndrome of qi stagnation and blood stasis admitted to Hubei Hospital of Traditional Chinese Medicine from May 2020 to December 2021 were selected and divided into chemotherapy group and combination group by random number table method, with 60 cases in each group. The chemotherapy group received chemotherapy alone (Cisplatin + Gemcitabine), and the combination group received supplementing chemotherapy with Yiqi Fuzheng Xiaoji Formula. Both groups were treated continuously for two months. The short-term efficacy, side effects, and quality of life before and after treatment were observed. Results The short-term clinical efficacy of the combination group was better than that of the chemotherapy group, and the objective remission rate and disease control rate were higher than those of the chemotherapy group, the differences were statistically significant (P＜0.05). The degree of leukopenia, thrombocytopenia, liver and kidney function injury, nausea, vomiting, peripheral neurotoxicity in combination group were less than those in chemotherapy group, and the differences were statistically significant (P＜0.05). After treatment, scores of physical function, role function, emotional function, cognitive function, and social function in both groups were higher than those before treatment, the scores of physical function, role function, emotional function, and social function in combination group were higher than those in chemotherapy group, and the differences were statistically significant (P＜0.05). Conclusion Supplementing chemotherapy with Yiqi Fuzheng Xiaoji Formula can reduce the side effects of drugs, enhance the anti-tumor effect, and improve the quality of life of advanced lung cancer patients with syndrome of qi stagnation and blood stasis, which has high clinical value.

Key words： Yiqi Fuzheng Xiaoji Formula Advanced lung cancer Chemotherapy Side effects Quality of life

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	GUO Guanghui1 ZHENG Lan1 YANG Junshu1 WANG Qiyuan2 LI Yue1

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GUO Guanghui1 ZHENG Lan1 YANG Junshu1 WANG Qiyuan2 LI Yue1. Influence of supplementing chemotherapy with Yiqi Fuzheng Xiaoji Formula on the quality of life and side effects in advanced lung cancer patients with syndrome of qi stagnation and blood stasis[J]. 中国医药导报, 2023, 20(10): 109-112,121.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.10.24 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I10/109

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