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| Analysis of the correlation between tumor and blood lipids and research progress of lipid-lowering drugs in tumor |
| MAO Xueyang1 GU Ning2 HU Hairui1 WEI Tianyi1 LI Zhigang2 |
1.School of Acupuncture and Massage, Henan University of Chinese Medicine, Henan Province, Zhengzhou 450046, China;
2.Department of Oncology, the Third Affiliated Hospital of Henan University of Chinese Medicine, Henan Province, Zhengzhou 450008, China
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Abstract After reviewing a large number of domestic and foreign literatures, triglycerides, total cholesterol, and low density lipoprotein cholesterol are found to be positively correlated with the occurrence and development risks of many tumors, and negatively correlated with the occurrence and development risks of a few tumors. Different studies have revealed inconsistent results of the correlation between the occurrence and development risk of tumor and triglyceride. However, high density lipoprotein cholesterol is negatively correlated with the occurrence and development risk of tumor. There have been basic and applied studies on statins, beta, cholesterol absorption inhibitors, antioxidant-probucol, pre-protein converting enzyme subtilisin inhibitor, nicotinic acid, and other chemical and traditional Chinese medicine lipid-lowering drugs in tumor treatment, and preliminary study on their target and mechanism. This paper found that the occurrence and development of tumors are closely related to the level of blood lipids, and the mechanism of the anti-tumor effect of lipid-lowering drugs needs further study.
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