|
|
|
| Exploring Professor Huang Li’s experience in treating different types of essential hypertension based on data mining |
| REN Weiquan1 ZHANG Gaoyu2 LIAO Jiangquan3 YAO Ruiqi2 HUANG Li3▲ |
1.Department of Traditional Chinese Medicine, Xuanwu Hospital Capital Medical University, Beijing 100053, China;
2.Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China;
3.National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China
|
|
|
|
Abstract Objective To analyze the medical case prescriptions of Professor Huang Li for the treatment of essential hypertension, and to summarize the relevant medication rules of Professor Huang Li for the treatment of essential hypertension. Methods The 597 prescriptions written by Professor Huang Li at China-Japan Friendship Hospital from January 2014 to December 2019 were collected, and frequency analysis, cluster analysis, and association rule analysis were performed to observe the distribution of their patient evidence types and core drug combinations. Results The 597 prescriptions included in the analysis were counted according to the evidence of liver-yang hyperactivity, qi deficiency and blood stasis, wind-phlegm upheaval, yin deficiency and fire stasis, and blood stasis, among which 365 patients (60.93%) with liver-yang hyperactivity syndrome, 79 patients (13.19%) with wind-phlegm upheaval syndrome, 72 patients (12.02%) with yin deficiency and fire stasis syndrome, 47 patients (7.85%) with qi deficiency and blood stasis syndrome, 34 patients (5.68%) with blood stasis syndrome. Cluster analysis and association rule analysis showed that the core Chinese medicine combination of liver-yang hyperactivity syndrome was Puerariae Lobatae Radix-Uncariae Ramulus cum Uncis-Chuanxiong Rhizoma-Gastrodiae Rhizoma. The core Chinese medicine combination of wind-phlegm syndrome was Atractylodis- Macrocephalae Rhizoma-Rhodiola rosea-Semen Platycladi. The core Chinese medicine combination of yin deficiency and fire was Taxilli Herba-Paeoniae Radix Rubra. The core Chinese medicine combination of qi deficiency and blood stasis syndrome was Chuanxiong Rhizoma - Notoginseng Radix. The core Chinese medicine combination of stasis block syndrome was Macrocephalae Rhizoma-Croci Stigma-Astragali Radix-Notoginseng Radix. Cluster analysis showed that the syndrome of liver-yang hyperactivity, qi deficiency and blood stasis, wind-phlegm upheaval, yin deficiency and fire stasis and blood stasis were clustered into 5, 5, 4, 5, and 4 categories respectively. Conclusion Professor Huang Li’s clinical treatment of primary hypertension commonly used to pacify the liver and calming the wind, invigorating blood stasis and calming the mind, paying attention to the important role of the liver in the pathogenesis of hypertension and pathological factors such as blood stasis, and using targeted drug combinations.
|
|
|
|
|
|
[1] Williams B，Mancia G，Spiering W，et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension [J]. Eur Heart J，2018，39：3021-3104.
[2] Wang ZW，Chen Z，Zhang LF，et al. Status of Hypertension in China Results From the China Hypertension Survey，2012-2015 [J]. Circulation，2018，137（22）：2344-2356.
[3] 中国心血管健康与疾病报告2020概要[J].中国循环杂志，2021，36（6）：521-545.
[4] 谢海琴.高血压常见药物不良反应及药物合理应用效果分析[J].北方药学，2019，16（12）：141-142.
[5] 中国高血压防治指南（2018年修订版）[J].中国心血管杂志，2019，24（1）：24-56.
[6] 国家市场监督管理总局，国家标准化管理委员会.GB/T 16751.2-2021，中医临床诊疗术语 第2部分：证候[S].北京：中国标准出版社，2021.
[7] 闫玉琴，刘红旭.刘红旭教授辨治老年高血压性眩晕的经验[J].中西医结合心脑血管病杂志，2022，20（3）：572- 574.
[8] 侯雅竹，姚红旗，王贤良，等.基于2943例高血压病患者的中医证候特征分析[J].中华中医药杂志，2020，35（9）：4590-4593.
[9] 雍苏南，谭元生.高血压病中医证型分布规律及合并病的相关性研究[J].辽宁中医杂志，2018，45（5）：914-916， 1117.
[10] 程苗苗，王承龙.1018例老年高血压病患者中医证型分布及相关因素分析[J].江苏中医药，2015，47（1）：34-36.
[11] 刘宇，毕颖斐，杨月，等.风眩源流考[J].中华中医药杂志，2021，36（7）：4328-4330.
[12] 柳威，邓林华，赵英强.天麻钩藤饮干预肝阳上亢型高血压病的临床疗效及机制探讨[J].天津中医药大学学报，2021，40（1）：51-54.
[13] 李海刚，胡晒平，周意，等.川芎主要药理活性成分药理研究进展[J].中国临床药理学与治疗学，2018，23（11）：1302-1308.
[14] 李昕，潘俊娴，陈士国，等.葛根化学成分及药理作用研究进展[J].中国食品学报，2017，17（9）：189-195.
[15] 于雪，胡文忠，姜爱丽，等.天麻的活性成分及功能性研究进展[J].食品工业科技，2016，37（8）：392-395，399.
[16] 蔡嘉缘，徐若瑶，高祥福.“治风先治血”理论探讨与治血三层次[J].浙江中医药大学学报，2022，46（5）：535- 538.
[17] 鞠梅，唐梁.升阳法在内科杂病中的运用举隅[J].四川中医，2020，38（11）：69-71.
[18] 司美龙，金华，马雪莉，等.培土宁风法治疗高血压病理论探析[J].辽宁中医杂志，2021，48（11）：80-83.
[19] 李尧，李伟，王琳，等.麸炒白术研究述要[J].山东中医药大学学报，2018，42（2）：182-185.
[20] 王小博，侯娅，王文祥，等.藏药红景天的药理作用及其机制研究进展[J].中国药房，2019，30（6）：851-856.
[21] 李丽丽，田文仓，刘茵，等.砂仁中化学成分及其药理作用的研究进展[J].现代生物医学进展，2018，18（22）：4390- 4396.
[22] 周静，许一凡.柏子仁化学成分与药理活性研究进展[J].化学研究，2019，30（4）：429-433.
[23] 管俊，崔瑛.桑寄生药理作用及临床应用研究进展[J].河北中医，2017，39（3）：460-463.
[24] 陆小华，马骁，王建，等.赤芍的化学成分和药理作用研究进展[J].中草药，2015，46（4）：595-602.
[25] 王莎莎，张钊，陈乃宏.枸杞子主要活性成分及药理作用研究进展[J].神经药理学报，2018，8（6）：53.
[26] 赵浩，江艳芬，周学春，等.活血化瘀药丹参多酚酸盐治疗瘀血阻络型高血压临床疗效观察[J].中西医结合心脑血管病杂志，2018，16（19）：2870-2872. |
|
|
|
