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| Data mining analysis of the medication pattern in the treatment of cerebral diseases in Ye Tianshi’s Clinical Guide of Medical Records |
| SONG Jia WEI Dongfeng CHEN Renbo GAI Guozhong LI He |
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
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Abstract Objective To analyze the medication pattern of brain diseases in Ye Tianshi’s Clinical Guide to Medical Cases, and to provide reference for the clinical treatment of brain diseases in Chinese medicine. Methods The medical cases for the treatment of brain disorders in the Clinical Guide of Medical Records was screened, the drugs in the prescriptions of the cases were standardized and entered them into the Traditional Chinese Medicine Heritage Assist Platform (V2.5), and the four qi, five tastes, the attribution, the frequency of use, and the common pairs of drugs in the entered prescriptions were analyzed, and the complex system entropy clustering algorithm to generate new prescriptions were used. Results A total of 116 prescriptions containing 151 herbal medicines were recorded, among which the proportion of cold and sweet medicines was the largest, and the liver meridian was the main attribute, while the more frequently used herbal medicines were Poria, Radix et Rhizoma, Ginseng, Lycium, and Chrysanthemum. Twenty-four sets of association rules with support ≥8 and confidence ≥ 0.5 were obtained, with correlation degree was 10, penalty degree was 4 and association coefficient ≥0.023, and 26 pairs of medicine pairs were obtained based on the improved mutual information method of mining, while 11 new prescriptions were obtained. Conclusion Ye Tianshi’s treatment of brain disorders emphasizes treatment from the kidney and filling the marrow, and is good at using warming and phlegm-transforming herbs, and the new prescriptions obtained are of certain clinical application value.
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