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| Study on medication rules of stroke based on the collation of ancient medical records |
| REN Qiaosheng1 CHEN Jian1 PENG Yongsheng2 LI Ying1 MA Yanan1 ZHANG Zihan1 GAO Ying3 CHANG Jingling1 |
1.Department of Encephalopathy, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100007,China;
2.School of Computer Science, Beihang University, Beijing 100191, China;
3.Institute of Traditional Chinese Medicine Encephalopathy, Beijing University of Chinese Medicine, Beijing 100007, China
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Abstract Objective To explore the medication rules of ancient medical records in stroke. Methods From December 2019 to December 2021, A total of 68 kinds of ancient books of traditional Chinese medicine medical records were selected, the prescription information of stroke medical records was extracted from medical records using Python3.8 programming language, input into Excel 2019, and the prescription data was normalized processing, statistical description, association analysis, and visual display. SPSS Statistics 26.0 software to complete the system cluster analysis. Results A total of 499 prescriptions were included in the first medical records, involving 302 types of drugs, with a total drug use frequency of 5 178 , and 32 kinds of high-frequency drugs (frequency ≥45). The drug with the highest frequency was Poria, which was 244 times, followed by Glycyrrhizae Radix Et Rhizoma, Pinelliae Rhizoma, Angelicae Sinensis Radix, Ginseng Radix Et Rhizoma, Atractylodis Macrocephalae Rhizoma, and so on. The drug natures of high frequency drugs were mainly warm, cold, and plain, and the flavours of drugs was mainly sweet, bitter, and pungent, and the drugs were mainly channeled into the spleen, lung, heart, stomach, liver, and kidney channels. A total of ten groups of core drug combinations were obtained by association analysis. The 32 high frequency drugs were divided into seven categories by systematic cluster analysis. Conclusion The drugs used in ancient medical records of stroke mainly focus on invigorating spleen and benefiting qi, eliminating phlegm and extinguish wind, regulating liver and kidney, emphasizing both strengthening vital qi to eliminate pathogenic factor, giving consideration to both manifestation and root cause, which can be used for clinical reference.
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