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| Research progress of action on the mangiferin regulating glycolipid metabolism |
| XU Yahui1 YIN Jianzhong2 RUAN Xiyu1 ZHAO Ting1 ZHANG Qiao1 |
1.School of Public Health, Kunming Medical University, Yunnan Province, Kunming 650500, China;
2.Baoshan College of Traditional Chinese Medicine, Yunnan Province, Baoshan 678000, China
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Abstract Glycolipid metabolism work together to maintain the energy needed for life, moreover, glucose metabolism and lipid metabolism are closely related and interact with each other. The disorder of glycolipid metabolism is one of the main reasons for the occurrence and development of various chronic diseases. Mangiferin, also known as formononetin, is mainly found in common plants of mangifera and gentianaceae. Mangiferin has various pharmacological effects and plays an indispensable role in glycolipid metabolic diseases. Based on the natural biological activity of mangiferin in recent years, this paper mainly analyzes and discusses the mechanism and bioavailability of mangiferin regulating glycolipid metabolism, in order to provide new ideas for clinical disease prevention and application, development of functional drug and food, and production optimization.
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[1] Kumar R，Priyadarshi RN，Anand U. Non-alcoholic fatty liver disease：growing burden，adverse outcomes and associations [J]. J Clin Transl Hepatol，2020，8（1）：76-86.
[2] O’Malley PG，Arnold MJ，Kelley C，et al. Management of dyslipidemia for cardiovascular disease risk reduction：synopsis of the 2020 Updated U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline [J]. Ann Intern Med，2020，173（10）：822-829.
[3] 赵冬.中国人群血脂异常流行趋势和治疗控制现状[J].中华心血管病杂志，2019，47（5）：341-343.
[4] Pinchevsky Y，Butkow N，Raal FJ，et al. Demographic and clinical factors associated with development of type 2 diabetes：a review of the literature [J]. Int J Gen Med，2020，13：121-129.
[5] Sekar V，Mani S，Malarvizhi R，et al. Positive interaction of mangiferin with selected oral hypoglycemic drugs：a therapeutic strategy to alleviate diabetic nephropathy in experimental rats [J]. Mol Biol Rep，2020，47（6）：4465-4475.
[6] Sferrazzo G，Palmeri R，Vanella L，et al. Mangifera indica L. leaf extract induces adiponectin and regulates adipogenesis [J]. Int J Mol Sci，2019，20（13）：3211.
[7] Lebaka VR，Wee YJ，Ye W，et al. Nutritional composition and bioactive compounds in three different parts of mango fruit [J]. Int J Environ Res Public Health，2021，18（2）：741.
[8] Nian SH，Li HJ，Liu EH，et al. Comparison of α-glucosidase inhibitory effect and bioactive constituents of Anemarrhenae Rhizoma and Fibrous Roots [J]. J Pharm Biomed Anal，2017，145：195-202.
[9] Bulugonda RK，Kumar KA，Gangappa D，et al. Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome [J]. Sci Rep，2017，7：42683.
[10] Mykhailenko O，Korinek M，Ivanauskas L，et al. Qualitative and quantitative analysis of ukrainian iris species：a fresh look on their antioxidant content and biological activities [J]. Molecules，2020，25（19）：4588.
[11] Bhargava S，Shah MB. Evaluation of efficacy of Bombax ceiba extract and its major constituent，mangiferin in streptozotocin （STZ）-induced diabetic rats [J]. J Complement Integr Med，2020，18（2）：311-318.
[12] Xu X，Chen Y，Song J，et al. Mangiferin suppresses endoplasmic reticulum stress in perivascular adipose tissue and prevents insulin resistance in the endothelium [J]. Eur J Nutr，2018，57（4）：1563-1575.
[13] Petersen MC，Shulman GI. Mechanisms of insulin action and insulin resistance [J]. Physiol Rev，2018，98（4）：2133-2223.
[14] Ye DW，Rong XL，Xu AM，et al. Liver-adipose tissue cros-stalk：a key player in the pathogenesis of glucolipid metabolic disease [J]. Chin J Integr Med，2017，23（6）：410-414.
[15] Munhoz ACM，Frode TS. Isolated compounds from natural products with potential antidiabetic activity—a systematic review [J]. Curr Diabetes Rev，2018，14（1）：36-106.
[16] Zhang Q，Kong X，Yuan H，et al. Mangiferin improved palmitate-induced-insulin resistance by promoting free fatty acid metabolism in HepG2 and C2C12 cells via PPARα：mangiferin improved insulin resistance [J]. J Diabetes Res，2019，2019：2052675.
[17] Singh AK，Raj V，Keshari AK，et al. Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ/ GLUT4 dual agonistic action with strong metabolic regulation [J]. Chem Biol Interact，2018，280：33-44.
[18] Lin H，Teng H，Wu W，et al. Pharmacokinetic and metabolomic analyses of Mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease [J]. BMC Pharmacol Toxicol，2020，21（1）：59.
[19] Semwal DK，Kumar A，Aswal S，et al. Protective and therapeutic effects of natural products against diabetes mellitus via regenerating pancreatic β-cells and restoring their dysfunction [J]. Phytother Res，2021，35（3）：1218-1229.
[20] Wang H，He X，Lei T，et al. Mangiferin induces islet regeneration in aged mice through regulating p16INK4a [J]. Int J Mol Med，2018，41（6）：3231-3242.
[21] Sha H，Zeng H，Zhao J，et al. Mangiferin ameliorates gestational diabetes mellitus-induced placental oxidative stress，inflammation and endoplasmic reticulum stress and improves fetal outcomes in mice [J]. Eur J Pharmacol，2019， 859：172522.
[22] Liu YW，Zhu X，Zhang L，et al. Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats [J]. Eur J Pharmacol，2013，721（1/3）：355-364.
[23] Hou J，Zheng D，Fung G，et al. Mangiferin suppressed advanced glycation end products （AGEs） through NF-κB deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats [J]. Can J Physiol Pharmacol，2016，94（3）：332-340.
[24] Song Y，Liu W，Tang K，et al. Mangiferin alleviates renal interstitial fibrosis in streptozotocin-induced diabetic mice through regulating the PTEN/PI3K/Akt signaling pathway [J]. J Diabetes Res，2020，2020：9481720.
[25] Zhang Y，Chen Q，Liu MY，et al. Effects of benzophenones from mango leaves on lipid metabolism [J]. Chem Pharm Bull（Tokyo），2019，67（7）：634-639.
[26] Ren K，Li H，Zhou HF，et al. Mangiferin promotes macrophage cholesterol efflux and protects against atherosclerosis by augmenting the expression of ABCA1 and ABCG1 [J]. Aging（Albany NY），2019，11（23）：10992-11009.
[27] Li J，Liu M，Yu H，et al. Mangiferin improves hepatic lipid metabolism mainly through its metabolite-norathyriol by modulating SIRT-1/AMPK/SREBP-1c signaling [J]. Front Pharmacol，2018，9：201.
[28] Na L，Zhang Q，Jiang S，et al. Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia：a double-blind randomized controlled trial [J]. Sci Rep，2015，5：10344.
[29] Guo F，Zi T，Liu L，et al. A 1H-NMR based metabolomics study of the intervention effect of mangiferin on hyperlipidemia hamsters induced by a high-fat diet [J]. Food Funct，2017，8（7）：2455-2464.
[30] Timalsina D，Pokhrel KP，Bhusal D. Pharmacologic activities of plant-derived natural products on respiratory diseases and inflammations [J]. Biomed Res Int，2021，2021：1636816.
[31] Liu M，Liu Y，Ge Y，et al. Solubility，antioxidation，and oral bioavailability improvement of mangiferin microparticles prepared using the supercritical antisolvent method [J]. Pharmaceutics，2020，12（2）：90.
[32] Kammalla AK，Ramasamy MK，Inampudi J，et al. Comparative pharmacokinetic study of mangiferin after oral administration of pure mangiferin and US patented polyherbal formulation to rats [J]. AAPS PharmSciTech，2015，16（2）：250-258.
[33] Septiana I，Nguyen TTH，Lim S，et al. Enzymatic synthesis and biological characterization of a novel mangiferin glucoside [J]. Enzyme Microb Techno，2020，134：109479.
[34] Wang Y，Karmakar T，Ghosh N，et al. Targeting mangiferin loaded N-succinyl chitosan-alginate grafted nanoparticles against atherosclerosis—a case study against diabetes mediated hyperlipidemia in rat [J]. Food Chem，2022，370：131376. |
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