溃疡性结肠炎中的色氨酸代谢及作用机制

doi:10.20047/j.issn1673-7210.2023.06.12

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Abstract The pathogenesis of ulcerative colitis (UC) is still unclear, but it is generally considered to be caused by immune disorders caused by environmental factors, microorganisms, and metabolic disorders in the background of genetic susceptibility. As an essential amino acid in mammals, tryptophan can regulate intestinal barrier function, mucosal immune cells, and gut microbiota through different metabolic pathways, thereby participating in the occurrence and development of UC. Therefore, regulating the metabolic pathways or metabolites of tryptophan may become a new strategy for the treatment of UC in the future. This article will review the research progress of tryptophan metabolism and mechanism of the action in ulcerative colitis, in order to provide new ideas and methods for its clinical diagnosis and treatment.

Key words： Tryptophan metabolism Ulcerative colitis Gut barrier Immune homeostasis Gut microbiota

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	HUANG Can MAO Tangyou SUN Zhongmei LI Junxiang ZHANG Wenji WANG Zhibin

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HUANG Can MAO Tangyou SUN Zhongmei LI Junxiang ZHANG Wenji WANG Zhibin. Tryptophan metabolism and mechanism of action in ulcerative colitis[J]. 中国医药导报, 2023, 20(6): 55-58.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.06.12 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I6/55

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