右美托咪定对老年宫颈癌Ⅰa期手术患者心肌保护及血清miRNA-30a、miRNA-30b的影响

doi:10.20047/j.issn1673-7210.2023.04.25

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (704 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the effects of Dexmedetomidine (Dex) on myocardial protection as well as serum miRNA-30a and miRNA-30b of elderly patients undergoing stage Ⅰa cervical cancer surgery. Methods A total of 60 elderly patients who underwent stage Ⅰa cervical cancer surgery in Guigang People’s Hospital, Guangxi Zhuang Autonomous Region from January 2021 to March 2022 were selected as object of observation. According to the random number table method, they were divided into control group and experimental group, with 30 cases in each group. The control group was given total intravenous anesthesia by Propofol combined with Remifentanil target controlled infusion, while the experimental group was given Dex according to 0.8 μg/kg by intravenous pumping from 15 min before induction of anesthesia to 10 min after the induction, and 0.4 μg/(kg·h) was maintained until 30 min before the end of surgery, and other anesthesia methods were the same as those in the control group. The heart rate (HR) and mean arterial pressure (MAP) of two groups were compared immediately after intubation (T0), 10 min after skin incision (T1), and at the end of surgery (T2); serum creatine kinase (CK), creatine kinase MB isoenzyme (CK-MB), miR-30a, and miR-30b were compared between two groups at 15 min before surgery and 6, 12, and 24 h after surgery. Results At T1 and T2, HR and MAP in both groups were lower than those at T0, and the differences were statistically significant (P＜0.05); HR and MAP of experimental group were lower than those of control group, and the differences were statistically significant (P＜0.05). At 6, 12, and 24 h after surgery, CK, CK-MB, and miR-30a were higher than those at 15 min before surgery, while miR-30b was lower than that at 15 min before surgery, and the differences were statistically significant (P＜0.05); CK, CK-MB, miR-30a, and miR-30b of experimental group were lower than those of control group, and the differences were statistically significant (P＜0.05). Conclusion Dex has a good protective effect on the myocardium of elderly patients undergoing stage Ⅰa cervical cancer surgery, and can reduce the expression levels of serum miR-30a and miR-30b.

Key words： Dexmedetomidine Stage Ⅰa cervical cancer Myocardial injury Myocardial zymogram miRNA-30a miRNA-30b

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIANG Kaiyuan LI Zejun LI Shuizhong LIANG Dijie

Cite this article:

LIANG Kaiyuan LI Zejun LI Shuizhong LIANG Dijie. Effects of Dexmedetomidine on myocardial protection and serum miRNA-30a and miRNA-30b of elderly patients undergoing stage Ⅰa cervical cancer surgery[J]. 中国医药导报, 2023, 20(4): 112-115,129.

URL:

https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.04.25 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I4/112

[1] 王晓辉.宫颈癌的流行现状与防控策略[J].甘肃医学，2020， 39（12）：1064-1066，1076.
[2] 李艳凤.分析两癌筛查对妇女早期诊治癌症的价值体会[J].国际感染病学（电子版），2020，9（2）：342-343.
[3] 龚拯，韦慧君，栗俊，等.右美托咪定药理及其对器官保护作用的研究进展[J].中国临床新医学，2020，13（10）：1065-1069.
[4] 钱露露，任映梅.右美托咪定对合并冠心病的老年全髋关节置换术患者心功能的影响[J].中国医药导报，2022， 19（13）：111-114.
[5] 张辉，彭晓静，李金秋，等.右美托咪定对妇科腹腔镜手术围术期患者炎性因子及应激反应的影响[J].河北北方学院学报（自然科学版），2019，35（2）：8-11.
[6] Correia de Sousa M，Gjorgjjeva M，Dolicka D，et al. Deciphering miRNAs’ action through miRNA editing [J]. Int J Mol Sci，2019，20（24）：6249-6270.
[7] Liu ZJ，Mi M，Zheng X，et al. MiR-30A/SOX4 double negative feedback loop is modulated by disulfiram and regulates EMT and stem cell-like properties in breast cancer [J]. J Cancer，2021，12（16）：5053-5065.
[8] 胡莹，齐凡星，张明，等.miR-30b对心肌细胞凋亡的影响的研究[J].国际免疫学杂志，2018，41（4）：408-411.
[9] 梁开远，黄光梅，李耀松，等.右美托咪定用于老年患者宫颈癌手术麻醉效果及对心功能、心脏血清学指标的影响[J].药物流行病学杂志，2020，29（7）：453-458.
[10] 李静，索红燕，孔为民.《国际妇产科联盟（FIGO）2018癌症报告：宫颈癌新分期及诊治指南》解读[J].中国临床医生杂志，2019，47（6）：646-649.
[11] 中华医学会心血管病学分会心力衰竭学组.中国心力衰竭诊断和治疗指南2018[J].中华心血管病杂志，2018， 46（10）：762-783.
[12] 邓小明，姚尚龙，于布为，等.现代麻醉学[M].5版.北京：人民出版社，2020：1096-1097.
[13] 孟祥婷，张弛，张励才.右美托咪定对单侧乳癌改良根治术患者麻醉苏醒期躁动和术后疼痛的影响[J].现代肿瘤医学，2019（17）：3121-3124.
[14] 罗猛强，姜思琪，邓萌，等.右美托咪定镇静催眠作用机制进展[J].国际麻醉学与复苏杂志，2020，41（11）：1116- 1120.
[15] 何东元，梁靖瑶，易小杏，等.胸腔镜与开胸肺叶切除术对早期肺癌患者炎症因子水平、免疫功能及心肺功能的影响[J].微创医学，2022，17（3）：290-295.
[16] Gu W，Tang W，Zhang Z，et al. Two different troponin isoforms for detecting early myocardial injury after curative resection of oesophageal cancer [J]. J Cardiothorac Surg，2020，15（1）：189-197.
[17] 徐凯平，徐彦，沈妍，等.右美托咪定对老年宫颈癌手术患者术后谵妄的影响[J].癌症进展，2021，19（3）：280- 282，289.
[18] 刘琼丽，李玲，周斐，等.右美托咪定联合舒芬太尼、地佐辛术后静脉镇痛方案对宫颈癌根治术患者术后睡眠质量的影响[J].肿瘤基础与临床，2020，33（5）：429-430.
[19] 李娟，李卫东，原忠伟，等.不同剂量右美托咪定对宫颈癌手术患者的麻醉效果及安全性[J].癌症进展，2020， 18（24）：2567-2570.
[20] 陈建树，瞿玉莲，陈微.右美托咪啶联合地佐辛用于宫颈癌根治手术中对心率、平均动脉压及脑电双频指数评分的影响[J].中国妇幼保健，2020，35（3）：2385-2388.
[21] 魏成敏.硬膜外麻醉复合全身麻醉、单纯全身麻醉对老年腹部手术患者心肌损伤的情况比较[J].中国现代药物应用，2020，14（10）：10-13.
[22] 孙鹏，贾兆晋，王英，等.右美托咪定对冠状动脉旁路移植术老年患者心脑功能的影响[J].临床药物治疗杂志，2022，20（7）：80-85.
[23] 张帆.冠状动脉粥样硬化性心脏病慢性心力衰竭患者和血清miR-30a表达水平与心功能和心肌重构的相关性[J].广东医学，2021，42（11）：1389-1392.
[24] 李斌，胡杰，赵勇鹏，等.微小RNA-30b在急性心肌缺血中的作用及其机制[J].中华实验外科杂志，2020，37（8）：1535-1537.
[25] Li B，Hu J，Chen X. MicroRNA-30b protects myocardial cell function in patients with acute myocardial ischemia by targeting plasminogen activator inhibitor-1 [J]. Exp Ther Med，2018，15（6）：5125-5132.