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Research progress on mechanism of active ingredients of Astragali Radix in the treatment of diabetic nephropathy |
MENG Sixuan1 YAO Xingmei1 WU Xinye1 LI Zhaodong2 WANG Hao1 |
1.Department of Nephrology, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China;
2.Department of Acupuncture and Moxibustion, Beibei Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, Chongqing 400700, China |
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Abstract Diabetic nephropathy is a chronic kidney disease caused by diabetes, which is an important cause of end-stage renal failure and even death in patients with diabetes. Astragali Radix has unique advantages in treating diabetic nephropathy. The active ingredients of Astragali Radix in the treatment of diabetic nephropathy involve anti-inflammatory, anti-endoplasmic reticulum stress, regulation of autophagy and other mechanisms. This article briefly reviews the mechanism of Astragali Radix active ingredients in the treatment of diabetic nephropathy in recent years, in order to provide new ideas for clinical and experimental research.
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