天然高分子材料水凝胶应用于软骨缺损修复的研究进展

doi:10.20047/j.issn1673-7210.2023.04.10

Abstract
Figure/Table
References (23)
Related Citation (15)

Download: PDF (706 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Cartilage defect is a lesion of hyaline cartilage of a joint caused by disease, trauma， and aging and it is also one of the main pathological features of osteoarthritis (OA). As a chronic degenerative disease OA has been a challenge for clinical orthopedic surgeons. Surgical approaches such as microfracture, articular chondroplasty, and chondrocyte transplantation have been more successful in recent years, but are not yet able to completely heal cartilage damage and are associated with contraindications to surgery, infection, and immune response. The appearance of cartilage tissue engineering has made cartilage regeneration possible, the natural polymer materials based on polysaccharides and proteins, have excellent biocompatibility, degradability, and unique self-healing ability, pointing the way in a new direction for cartilage defect repair. This paper reviews the application of natural polymer hydrogels in cartilage defect repair aiming to provide some theoretical references for cartilage regeneration.

Key words： Natural polymer Hydrogels Cartilage Tissue engineering Osteoarthritis Overview

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	MA Xiaohang1 ZENG Linru1 LUO Gan1 KANG Yi2 GONG Shijie1

Cite this article:

MA Xiaohang1 ZENG Linru1 LUO Gan1 KANG Yi2 GONG Shijie1. Research progress of the application of natural polymer hydrogels in the repair of cartilage defect[J]. 中国医药导报, 2023, 20(4): 47-51.

URL:

https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.04.10 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I4/47

[1] GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global，regional，and national incidence，prevalence，and years lived with disability for 354 diseases and injuries for 195 countries and territories，1990-2017：a systematic analysis for the Global Burden of Disease Study 2017 [J]. Lancet，2018，392（10159）：1789-1858.
[2] Jiang S，Liang H. Hyaluronic acid-a highly sought after beauty tool [J]. Healthy World，2020，2：25-27.
[3] Li L，Yu F，Zheng L，et al. Natural hydrogels for cartilage regeneration：Modification，preparation and application [J]. J Orthop Translat，2018，17：26-41.
[4] Deng Y，Sun AX，Overholt KJ，et al. Enhancing chondrogenesis and mechanical strength retention in physiologically relevant hydrogels with incorporation of hyaluronic acid and direct loading of TGF-β [J]. Acta Biomater，2019，83：167- 176.
[5] Ren P，Zhang H，Dai Z，et al. Stiff micelle-crosslinked hyaluronate hydrogels with low swelling for potential cartilage repair [J]. J Mater Chem B，2019，7（36）：5490-5501.
[6] Müller M，Öztürk E，Arlov Ø，et al. Alginate Sulfate-Nanocellulose Bioinks for Cartilage Bioprinting Applications [J]. Ann Biomed Eng. 2017，45（1）：210-223.
[7] Critchley S，Cunniffe G，O’Reilly A，et al. Regeneration of Osteochondral Defects Using Developmentally Inspired Cartilaginous Templates [J]. Tissue Eng Part A，2019，25（3/4）：159-171.
[8] Chu Y，Huang L，Hao W，et al. Long-term stability，high strength，and 3D printable alginate hydrogel for cartilage tissue engineering application [J]. Biomed Mater，2021，16（6）.
[9] Mou D，Yu Q，Zhang J，et al. Intra-articular Injection of Chitosan-Based Supramolecular Hydrogel for Osteoarthritis Treatment [J]. Tissue Eng Regen Med，2021，18（1）：113- 125.
[10] Gossla E，Bernhardt A，Tonndorf R，et al. Anisotropic Chitosan Scaffolds Generated by Electrostatic Flocking Combined with Alginate Hydrogel Support Chondrogenic Differentiation [J]. Int J Mol Sci，2021，22（17）：9341.
[11] Rogan H，Ilagan F，Tong X，et al. Microribbon-hydrogel composite scaffold accelerates cartilage regeneration in vivo with enhanced mechanical properties using mixed stem cells and chondrocytes [J]. Biomaterials，2020，228：119579.
[12] Yang J，Zhang YS，Yue K，et al. Cell-laden hydrogels for osteochondral and cartilage tissue engineering [J]. Acta Biomater，2017，57：1-25.
[13] Stefani RM，Lee AJ，Tan AR，et al. Sustained low-dose dexamethasone delivery via a PLGA microsphere-embedded agarose implant for enhanced osteochondral repair [J]. Acta Biomater，2020，102：326-340.
[14] Yang F，Zhang Y，Liu B，et al. Basic fibroblast growth factor and agarose gel promote the ability of immune privilege of allogeneic cartilage transplantation in rats [J]. J Orthop Translat，2019，22：73-80.
[15] Ng JY，Obuobi S，Chua ML，et al. Biomimicry of microbial polysaccharide hydrogels for tissue engineering and regenerative medicine-A review [J]. Carbohydr Polym，2020， 241：116345.
[16] Kim WK，Choi JH，Shin ME，et al. Evaluation of cartilage regeneration of chondrocyte encapsulated gellan gum-based hyaluronic acid blended hydrogel [J]. Int J Biol Macromol，2019，141：51-59.
[17] Zhang Y，Cao Y，Zhao H，et al. An injectable BMSC-laden enzyme-catalyzed crosslinking collagen-hyaluronic acid hydrogel for cartilage repair and regeneration [J]. J Mater Chem B，2020，8（19）：4237-4244.
[18] Yang J，Xiao Y，Tang Z，et al. The negatively charged microenvironment of collagen hydrogels regulates the chondrogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo [J]. J Mater Chem B，2020，8（21）：4680-4693.
[19] Wang Q，Han G，Yan S，et al. 3D Printing of Silk Fibroin for Biomedical Applications [J]. Materials （Basel），2019，12（3）：504.
[20] Li T，Song X，Weng C，et al. Silk fibroin/carboxymethyl chitosan hydrogel with tunable biomechanical properties has application potential as cartilage scaffold [J]. Int J Biol Macromol，2019，137：382-391.
[21] 佘荣峰，张一，陈龙，等.丝素蛋白-壳聚糖支架复合骨髓间充质干细胞体内构建组织工程化软骨的生物相容性[J].中国组织工程研究，2020，24（1）：27-32.
[22] Choi SM，Lee KM，Ryu SB，et al. Enhanced articular cartilage regeneration with SIRT1-activated MSCs using gelatin- based hydrogel [J]. Cell Death Dis，2018，9（9）：866.
[23] Suo H，Li L，Zhang C，et al. Glucosamine-grafted methacrylated gelatin hydrogels as potential biomaterials for cartilage repair [J]. J Biomed Mater Res B Appl Biomater，2020，108（3）：990-999.