Research progress of microRNA in different types of skeletal muscle atrophy
XIAO Ya HONG Li LI Suting CHEN Mao HUANG Xiaoyu ZHU Fangyi
Department of Gynecology and Obstetrics, People’s Hospital of Wuhan University, Hubei Province, Wuhan 430060, China
Abstract Skeletal muscle atrophy refers to the decrease of skeletal muscle quality and muscle function. Denervation, aging, chronic obstructive pulmonary disease, cancer, and other diseases can induce skeletal muscle atrophy, resulting in a decline in the quality of life of patients and an increased risk of death. However, the underlying mechanism of muscle atrophy is not fully understood. microRNA (miRNA) is a class of non-coding single-stranded RNA molecules encoded by endogenous genes, which are involved in a variety of physiological and pathological processes, including cell proliferation, differentiation, apoptosis, autophagy, tumorigenesis, and even epigenetics. In recent years, there are more and more studies on miRNA in skeletal muscle atrophy, and miRNA is expected to become a new molecular target for the diagnosis and treatment of skeletal muscle atrophy. This article reviews the research progress on the role of miRNA in different types of skeletal muscle atrophy.
Key words ：
MicroRNA
Skeletal muscle atrophy
Denervation
Aging
[1] Bethune J，Artus-Revel CG，Filipowicz W. Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells [J]. EMBO Rep，2012，13（8）：716- 723.
