|
|
|
| Bibliometrics and visualization analysis based on CiteSpace hotspots and trends in research of spleen deficiency syndrome |
| YU Chang1 XIONG Meng1 SONG Houpan1 QIU Jingyue1 LONG Cailing1 ZENG Meiyan2 YUAN Chengzhi3 TAN Meiling1 |
1.Key Laboratory of Traditional Chinese Medicine Diagnostics of Hunan Province, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China;
2.College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China;
3.Medical School, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China |
|
|
|
Abstract Objective To explore the CiteSpace was used to visualize the research status, trends and hot spots of spleen deficiency syndrome. Methods Literature related to spleen deficiency syndrome published from the establishment of China National Knowledge Infrastructure and Web of Science database to December 31, 2021 were collected. CiteSpace was used for visualization analysis of author, institution, keyword co-occurrence and emergence, keyword, time graph and time zone graph. Results A total of 2 474 Chinese and 61 English literatures were included. The publication of Chinese and English literature is generally on the rise. The author with the largest number of publications in Chinese literature is Shan Dehong, and English literature was GUANG JI. Liaoning University of Traditional Chinese Medicine published the most Chinese literature, while Shanghai University of Traditional Chinese Medicine published the most English literature. In addition to the subject word, the top three Chinese keywords were animal model, Sijunzi Decoction and epigastric pain, and the top three English keywords were traditional Chinese medicine, Sijunzi Decoction, the gut microbiota, cluster analysis of keywords showed that 15 clusters were obtained in Chinese literature and eight clusters were obtained in English literature, which mainly focused on the treatment of spleen deficiency syndrome, model preparation and pathogenic mechanism of spleen deficiency syndrome. Conclusion The research on spleen deficiency syndrome is mainly domestic research, and the cooperation among various groups needs to be strengthened. The pathogenic mechanism of spleen deficiency syndrome, the preparation of animal models, and the treatment of traditional Chinese medicine are the research hotspots in this field, and the future research trends are metabonomics, the treatment of spleen deficiency gastric cancer and gastric ulcer.
|
|
|
|
|
|
[1] 孟凡征，李亚男，赵金生，等.“脾虚证”实质的现代研究进展[J].时珍国医国药，2019，30（12）：2975-2977.
[2] 李振钰，许欣竹，刘文俊，等.脾气虚大鼠心肌细胞线粒体Lon蛋白酶和ClpXP复合物表达的研究[J].中华中医药杂志，2021，36（6）：3616-3619.
[3] 倪菲，王彩霞，李可大，等.论中医象思维在脾脏象理论构建中的应用[J].辽宁中医杂志，2017，44（10）：2074-2076.
[4] 程越，于漫，王彩霞.基于脾胃学说指导下的肠道微生态中医本质探讨[J].时珍国医国药，2020，31（8）：1946-1949.
[5] 李娟娟，王凤云，吕林，等.香砂六君子汤对功能性消化不良脾虚证大鼠胃动力及CRF，UCN2表达的影响[J].中国实验方剂学杂志，2022，28（3）：1-7.
[6] Gu Z，Wang Q，He HY，et al. Genetic variations associated with spleen-yang deficiency pattern of non-alcoholic fatty liver disease：A candidate gene study [J]. Eur J Integr Med，2020，33：101044.
[7] Xu J，Wang R，You S，et al. Traditional Chinese medicine Lingguizhugan decoction treating non-alcoholic fatty liver disease with spleen-yang deficiency pattern：Study protocol for a multicenter randomized controlled trial [J]. Curr Control Trials Cardiovasc Med，2020，21（1）：512.
[8] Ning YZ，Wu FZ，Xue S，et al. Enhanced functional connectivity of the default mode network （DMN） in patients with spleen deficiency syndrome：A resting-state fMRI study [J]. Medicine （Baltimore），2019，98（5）：e14372.
[9] Ning Y，Jia W，Yin D，et al. Disrupted Resting-State Functional Connectivity between the Dorsal Attention，Default Mode，and Frontoparietal Networks in Nonorganic Gastrointestinal Disorder Patients with Spleen Deficiency Syndrome [J]. Evid Based Complement Alternat Med，2021，2021：6681903.
[10] Lin Z，Ye W，Zu X，et al. Integrative metabolic and microbial profiling on patients with Spleen-yang-deficiency syndrome [J]. Sci Rep，2018，8（1）：6619.
[11] Lin Z，Sun X，Xie H，et al. Plasma metabolomics coupled with MetaboAnalyst and Ingenuity Pathway Analysis characterizes linoleic acid metabolism disorder in patients with spleen-yang-deficiency syndrome [J]. Eur J Integr Med，2018，19：72-79.
[12] 侯媛媛.中国跨区域创新合作的模式及影响研究[D].北京：北京理工大学，2015.
[13] 袁琴，王虚实，王君钰，等.参芪扶正汤联合GP化疗方案治疗IIIb、Ⅳ期非小细胞肺癌脾虚证临床研究[J].河南中医，2016，36（5）：832-834.
[14] 马丽娟，王锡恩，张静，等.益气健脾方对宫颈癌同步放化疗脾虚证候及免疫状态的影响[J].中华中医药学刊，2020，38（10）：236-239.
[15] 翟春艳，底婷婷，王燕，等.脾虚对银屑病样小鼠Treg/ Th17平衡偏移的影响[J].中华中医药杂志，2020，35（1）：123-128.
[16] 朱慧婷，尚宝令，李伯华，等.健脾润肤汤对特应性皮炎脾虚证面部皮肤生理指标的影响[J].时珍国医国药，2017， 28（4）：895-897.
[17] 王颖，侯丽辉，匡洪影.多囊卵巢综合征患者脾虚证与内分泌代谢异常相关性研究[J].辽宁中医药大学学报，2019，21（8）：114-117.
[18] 高子任，李跃华，许亚培.基于握力、肌肉含量、BMI对中医脾虚证与骨质疏松关系的研究[J].福建中医药，2018，49（5）：54-56.
[19] Zhao Q，Gao X，Yan G，et al. Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency syndrome [J]. Front Med，2020，14（3）：335-356.
[20] 翟美丽，于漫，刘俊兰，等.附子理中汤对脾阳虚大鼠脂质过氧化损伤和能量代谢障碍的影响[J].中华中医药学刊，2017，35（11）：2889-2891.
[21] 李骁峰，焦权明.枳术丸加减联合莫沙必利治疗脾虚证功能性消化不良的临床研究[J].实用中西医结合临床，2021，21（5）：13-14.
[22] 武书果.电针联合四君子汤在脾虚证型脓毒症患者肠道复苏中的临床效果研究[J].深圳中西医结合杂志，2020， 30（1）：56-58.
[23] 曾梅艳，陈雪莲，宋厚盼，等.脾气虚证动物模型造模方法与模型评价的研究概述[J].湖南中医药大学学报，2019， 39（2）：284-289.
[24] Qy A，Sm B，Wn A，et al. Label-free mass spectrometry- based proteomics for investigating the therapeutic mechanism of Sijunzi decoction on spleen deficiency syndrome - ScienceDirect [J]. Microchemical J，2021，164：105944.
[25] 琚婉君，郭蕾，陈少丽，等.补中益气汤改善脾虚型胃肠动力障碍大鼠代谢组学研究[J].中华中医药学刊，2020， 38（5）：69-73，271-272. |
|
|
|
