单核细胞/高密度脂蛋白比值与冠心病患者冠状动脉狭窄的关系

doi:10.20047/j.issn1673-7210.2022.34.21

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Abstract Objective To analyze the relationship between monocyte/high-density lipoprotein cholesterol ratio (MHR) and coronary artery stenosis in patients with coronary artery heart disease (CHD). Methods In this study, 127 CHD patients admitted to the Third Hospital of Changsha from February 2019 to December 2021 were divided into CHD group (97 cases) and non-CHD group (30 cases) according to the results of coronary angiography. The differences of clinical data, laboratory biochemical indexes, and MHR levels between the two groups were compared, and the correlation between serum MHR level and other indexes in CHD group was analyzed. According to the Gensini score of CHD group, the patients were divided into mild group (31 cases) (＜ 20 points), moderate group (35 cases) (20-43 points), and severe group (31 cases) (＞43 points). The difference of MHR among the three groups was compared, the correlation between the MHR level and Gensini score in the CHD group was analyzed, and the diagnostic efficacy of MHR in predicting coronary artery stenosis in CHD patients was evaluated by receiver operator characteristic curve. Results The male proportion, smoking history proportion, type 2 diabetes mellitus proportion, hypertension history proportion, fasting blood glucose, low-density lipoprotein cholesterol, uric acid, hypersensitive C-reactive protein, white blood cell, myeloperoxidase, and MHR in CHD group were all higher than those in non-CHD group, and the differences were statistically significant (P＜0.05). Correlation analysis showed that MHR in CHD group was positively correlated with low-density lipoprotein cholesterol, uric acid, hypersensitive C-reactive protein, myeloperoxidase, and leukocyte (r＞0, P＜0.05). The MHR of the severe group was higher than that of the mild and moderate groups, and the MHR of the moderate group was higher than that of the mild group, the differences were statistically significant(P＜0.05). Correlation analysis showed that MHR in CHD group was positively correlated with Gensini score (r＞0, P＜0.05). MHR predicted coronary artery stenosis in CHD patients with the area under the receiver operator characteristic curve of 0.929 (95%CI: 0.885-0.974, P＜0.05), truncation value of 0.42, sensitivity of 78.0%, specificity of 90.0%. Conclusion MHR can be used as an inflammatory marker for early diagnosis and evaluation the severity of coronary artery disease.

Key words： Monocyte/high-density lipoprotein ratio Coronary artery stenosis Coronary artery heart disease

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	XIAO Xiaoxia ZHANG Yumin WANG Yong SHI Wei LIANG Weifen LI Hui

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XIAO Xiaoxia ZHANG Yumin WANG Yong SHI Wei LIANG Weifen LI Hui. Relationship between monocyte/high-density lipoprotein ratio and coronary artery stenosis in patients with coronary heart disease[J]. 中国医药导报, 2022, 19(34): 90-93.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.34.21 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I34/90

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