益气活络生肌汤对气虚血瘀型糖尿病足患者的影响

doi:10.20047/j.issn1673-7210.2022.28.30

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Abstract Objective To observe the effect of Yiqi Huoluo Shengji Decoction on diabetic foot patients with qi deficiency and blood stasis type. Methods A total of 124 diabetic foot patients admitted to the First People’s Hospital of Lianyungang of Jiangsu Province from February 2020 to August 2021 were selected as the research subjects. They were randomly divided into control group and study group according to the random number table method, with 62 cases in each group. The control group was given vacuum sealing drainage treatment on the basis of conventional treatment, and study group was given Yiqi Huoluo Shengji Decoction on the basis of control group. Both groups were treated for eight weeks. The traditional Chinese medicine symptom scores and clinical efficacy of two groups were compared, the changes of wound healing, peripheral nerve sensory threshold, and dorsum of foot blood flow between two groups were recorded; the occurrence of adverse events during treatment in two groups was recorded. Results After treatment, the traditional Chinese medicine syndrome scores of the main symptom and secondary symptom in both groups were lower than those before treatment, and those in study group was lower than those in control group, and the differences were statistically significant, (P < 0.05). The curative effect of study group was better than that of control group, and the difference was statistically significant (P < 0.05). The appearance time of foot ulcer granulation tissue and wound healing time in study group were shorter than those in control group (P < 0.05). After treatment, the peripheral nerve sensory threshold in two groups was lower than that before treatment, that of study group was lower than that of control group, and the differences were statistically significant (P < 0.05). After treatment, inner diameter of blood vessels, blood flow velocity, and pulsatility index in both groups were higher than those before treatment, and those in study group were higher than those in control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the total incidence of adverse events between two groups (P > 0.05). Conclusion Yiqi Huoluo Shengji Decoction can enhance the therapeutic effect, accelerate wound healing, and improve peripheral nerve sensory function and blood circulation in patients with diabetic foot due to qi deficiency and blood stasis, with good safety.

Key words： Diabetic foot Vacuum sealing drainage Yiqi Huoluo Shengji Decoction Effect

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	ZHANG Tongyu YANG Chuanhui ZHENG Zhichen WANG Guofeng

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ZHANG Tongyu YANG Chuanhui ZHENG Zhichen WANG Guofeng. Effect of Yiqi Huoluo Shengji Decoction on diabetic foot patients with qi deficiency and blood stasis type[J]. 中国医药导报, 2022, 19(28): 136-139.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.28.30 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I28/136

[1] 吴然，白姣姣，赵楠，等.纠正可改变的足溃疡的危险因素是预防糖尿病足的关键[J].中华糖尿病杂志，2021，13（5）：454-456.
[2] 申金付，蒋瑞妹，王卓群，等.糖尿病足患者的死亡相关危险因素分析[J].中国现代医学杂志，2020，30（2）：90-94.
[3] 计鹏，张月，胡大海，等.皮肤牵张器联合负压封闭引流修复糖尿病足创面的临床效果[J].中华烧伤杂志，2020， 36（11）：1035-1039.
[4] 刘楚贤，陈世玖.负压封闭引流术治疗糖尿病足溃疡疗效的Meta分析[J].医学综述，2020，26（18）：3723-3728.
[5] 牛胜男，李国信，李世征，等.油调膏配合负压封闭引流治疗湿热毒盛型糖尿病足疗效分析[J].中国中西医结合外科杂志，2021，27（2）：328-331.
[6] 中国医师协会中西医结合医师分会内分泌与代谢病学专业委员会.糖尿病足病中医病证结合诊疗指南[J].中医杂志，2021，62（12）：1099-1104.
[7] 林立英，陈雪芳.益气活络生肌汤促糖尿病足溃疡面的愈合作用研究[J].中华中医药学刊，2020，38（4）：255-258.
[8] 中华医学会糖尿病学分会，中华医学会感染病学分会，中华医学会组织修复与再生分会.中国糖尿病足防治指南（2019版）（Ⅲ）[J].中华糖尿病杂志，2019，11（4）：238-247.
[9] 中华中医药学会糖尿病分会.糖尿病足中医诊疗标准[J].世界中西医结合杂志，2011，6（7）：618-625.
[10] 郑筱萸.中药新药临床研究指导原则[S].北京：中国医药科技出版社，2002：25-43.
[11] 国家中医药管理局.中华人民共和国中医药行业标准—中医病症诊断疗效标准（2012版）[S].北京：中国医药科技出版社，2012：214-215．
[12] 蒋竹奕，李莉，吴炎，等.糖尿病足小截肢影响因素分析[J].中国糖尿病杂志，2021，29（6）：433-437.
[13] 张悦，周冬梅，李伟，等.影响糖尿病足的危险因素及溃疡严重程度对预后的影响[J].中国老年学杂志，2021， 41（22）：4911-4914.
[14] 于鸿妲，闫英，王羽侬，等.糖尿病高危足的中医认识与证治经验[J].湖南中医药大学学报，2020，40（9）：1119-1122.
[15] 锁苗，李惠林，赵恒侠，等.国医大师张学文从内生毒邪论治糖尿病足[J].中医学报，2020，35（4）：807-810.
[16] 王广宇，王雨，王雷永，等.以“生肌三法”为代表的方药对糖尿病足伴慢性疮面作用机制的探讨[J].世界中医药，2020，15（14）：2116-2121.
[17] 赵进喜，关小宏，梁晓春，等.论糖尿病足的中医病机与防治策略[J].北京中医药，2021，40（12）：1333-1336.
[18] 赵泽阳，杨宇峰，石岩.糖尿病高危足中医病因病机及内治法探析[J].辽宁中医药大学学报，2021，23（3）：143-146.
[19] 赵丹钰，王高雷，路波.路波主任医师从少阴论治糖尿病足的临床经验[J].中国医药导报，2021，18（15）：171-174.
[20] 江山山，蒋锦燕，李桥桥，等.西红花与红花的抗血栓作用研究[J].中草药，2021，52（12）：3584-3590.
[21] 吴红旗，徐蓉.红花黄色素对急性冠状动脉综合征患者心血管事件的影响[J].现代中西医结合杂志，2020，29（14）：1569-1571，1575.
[22] 张建军，李伟，乐娜，等.赤芍及赤芍总单萜、赤芍总酚对热毒血瘀证大鼠的清热凉血散瘀功效[J].北京中医药大学学报，2020，43（3）：196-202.
[23] 何泽源，张妍妍，林楠，等.赤芍化学成分和药理作用及质量标志物的预测分析[J].中药材，2020，43（12）：3075-3080.
[24] 王倩，李柳潼，马永犇，等.白芍与赤芍化学成分和药理作用比较研究及质量标志物的预测分析[J].中国新药杂志，2021，30（12）：1093-1098.
[25] 李景宇，王梅青，宿佳，等.益气活血生肌方对高位复杂性肛瘘术后创面愈合的临床观察[J].中国临床医生杂志，2020，48（8）：1003-1005.