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| Research progress of ferroptosis function in the tumor-infiltrating lymphocyte |
| WANG Ronglin MA Peixiang HUA Lei YANG Cheng GUO Yongdong LI Junqiang SU Haichuan |
| Department of Oncology, Tangdu Hospital, Air Force Medical University, Shaanxi Province, Xi’an 710038, China |
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Abstract Ferroptosis is a novel kind of cell death which is induced by the accumulation of iron-dependent lipid peroxidation. It has been proved ferroptosis modulates the tumorigenesis and tumor progression. Tumor infiltrating immune cells are critical components of tumor microenvironment. By modulating immune response, tumor infiltrating immune cells regulate tumor development and affect immunotherapy response. Previous studies indicate ferroptosis affects tumor infiltrating immune cell function to modulate tumor progression. This review introduces the molecular mechanism of ferroptosis and summarizes the regulatory role of ferroptosis in tumor infiltrating immune cells, which is expected to provide new strategy to improve immunotherapy efficacy.
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