Abstract Objective To investigate the status quo of knowledge level of blood pressure medication use in patients with chronic kidney disease (CKD), to analyze its influencing factors, and in the hope of providing a basis for future interventions. Methods A total of 311 patients with CKD who were hospitalized in the Department of Nephrology in a tertiary hospital in Guangzhou from February to May 2021 were selected as the research subjects. The general information questionnaire, medication knowledge scale, rational drug use self-efficacy scale, and perception family support scale were used to investigate. Results The score of drug knowledge in this survey was (20.9±6.2) points. There were significant differences in the scores of medication knowledge among CKD patients with different age, education level, occupational status, per capita monthly income of the family, received antihypertensive drug-related knowledge health education, and read the drug instructions (P ＜ 0.05). Spearman rank correlation analysis showed that medication knowledge in CKD patients was positively correlated with rational medication self-efficacy (r = 0.470) and family support (r = 0.349) (P ＜ 0.05). The results of regression analysis showed that five variables, including education level, received of antihypertensive drug-related knowledge and health education, rational drug use self-efficacy, understanding of family support, and read drug instructions were the influencing factors in knowledge level of patient medication equation (P ＜ 0.05). They could jointly explain 35.0% of the total variation in medication knowledge. Conclusion Medical staff can carry out health education in a targeted manner in combination with various influencing factors of drug knowledge level, so as to improve the level of drug use knowledge.
YANG Cong1 YANG Mengqin2 XIA Jiayi2 FU Bo2 LIU Meng2 GONG Nirong2 AI Jun2 SU Jianping1. Status quo and influencing factors of knowledge level of antihypertensive drugs in patients with chronic kidney disease[J]. 中国医药导报, 2022, 19(24): 52-55.
[1] Delanaye P，Glassock RJ，De Broe ME. Epidemiology of chronic kidney disease：think （at least） twice! [J]. Clin Kidney J，2017，10（3）：370-374.
[2] K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease [Z]. 2004，43：S1-S290.
[3] Seng JJB，Tan JY，Yeam CT，et al. Factors affecting medication adherence among pre-dialysis chronic kidney disease patients：a systematic review and meta-analysis of literature [J]. Int Urol Nephrol，2020，52（5）：903-916.
[4] 彭一航，谢莉玲，陈娇娇，等.重庆市养老机构老年人用药现状及影响因素[J].护理研究，2019，33（22）：3836-3842.
[5] Mugomeri E，Ramathebane MV，Maja L，et al. Knowledge of disease condition and medications among hypertension patients in Lesotho [J]. J Am Soc Hypertens，2016，10（1）：41-46.
[6] 杨玉琴，杨慧玲，黄小丽，等.社区老年高血压病人用药现状与护理[J].全科护理，2013，11（30）：2806-2807.
[7] Amer M，Rahman N，Nazir SR，et al. Impact of pharmacist’s intervention on disease related knowledge，medication adherence，HRQoL and control of blood pressure among hypertensive patients [J]. Pak J Pharm Sci，2018， 31（6）：2607-2616.
[8] 陈燕师，孟凡莉，周小梅，等.患者用药依从行为调查及其影响因素分析[J].社区医学杂志，2016，14（11）：1-4.
[9] Risser J，Jacobson TA，Kripalani S. Development and psychometric evaluation of the Self-efficacy for Appropriate Medication Use Scale （SEAMS） in low-literacy patients with chronic disease [J]. J Nurs Meas，2007，15（3）：203-219.
[10] 罗志民，王思琛，谢文，等.青少年肾病综合征患者领悟家庭支持量表的编制[J].中国实用护理杂志，2006，22（16）：6-8.
[11] 沈志莹，郑凤，丁四清，等.居民药物素养相关国内外研究进展[J].中国护理管理，2018，18（7）：999-1003.
[12] 张佳颖，郭西芮，吴行伟，等.居民用药风险“知识-态度-行为”调查及影响因素研究[J].中国药房，2018，29（11）：1445-1448.
[13] 刘国珍，薛承斌，丁玉峰，等.湖北某高校社区居民安全用药现状调查以及用药风险因素分析[J].中国医院药学杂志，2021，41（17）：1795-1800.
[14] 陈建华，魏超，邓玲.医院—社区—家庭模式的多层面健康教育干预对老年慢性共病人群安全合理用药知信行影响的研究[J].中国医院药学杂志，2020，40（4）：452-455.
[15] Shi S，Shen Z，Duan Y，et al. Association Between Medication Literacy and Medication Adherence Among Patients With Hypertension [J]. Front Pharmacol，2019，22（10）：812-822.
[16] 王芝为，方媛媛，汪秋伊，等.高血压健康教育平面材料的可读性评估[J].中国健康教育，2020，36（12）：1122-1125.
[17] 宋再伟，谈志远，董淑杰，等.微信订阅号用于华法林用药教育的先导研究[J].中国临床药理学杂志，2018，34（1）：60-62.
[18] Hyoguchi N，Kamauchi T，Hoshino M，et al. Survey of Pharmacists’ Knowledge，Actions and Confidence in Medication Education to Patients with Hearing Disabilities [J]. Yakugaku Zasshi，2020，140（10）：1295-1298.
[19] 沈志莹，钟竹青，丁四清.高血压患者服药自我效能的研究现状[J].护理学杂志，2018，33（17）：102-105.
[20] Chuang L，Wu SV，Lee M，et al. The effects of knowledge and self-management of patients with early-stage chronic kidney disease：Self-efficacy is a mediator [J]. Jpn J Nurs Sci，2021，18（2）：78-88.
[21] Zhong Z，Shi S，Duan Y，et al. The Development and Psychometric Assessment of Chinese Medication Literacy Scale for Hypertensive Patients （C-MLSHP） [J]. Front Pharmacol，2020，11（2）：490-501.
[22] Shen Z，Shi S，Ding S，et al. Mediating Effect of Self-Efficacy on the Relationship Between Medication Literacy and Medication Adherence Among Patients with Hypertension [J]. Front Pharmacol，2020，11（5）：69-80.
[23] 黄月英，冯占春，咸越，等.农村高血压患者社会支持与用药依从性现状及相关性分析[J].中国卫生事业管理，2017，34（12）：913-916.
[24] 曾晓敏，胡佳佳，冯璐，等.门诊患者服用中药的用药疗程依从性影响因素分析[J].现代医院，2020，20（1）：64-67.
[25] 杨小娇，汪凤兰，张小丽，等.家庭关怀度和社会支持对老年人健康促进行为影响[J].中国公共卫生，2018，34（9）：1266-1269.
[26] Kim JM，Suarez-Cuervo C，Berger Z，et al. Evaluation of Patient and Family Engagement Strategies to Improve Medication Safety [J]. Patient，2018，11（2）：193-206.
