|
|
|
| Research progress on the relationship between NOX/ROS-NF-κB siginaling pathway and atherosclerosis |
| WEI Jiaming1 WANG Ziyan1 LIU Ting2 WANG Jianguo2 GUO Zhihua2 |
1.The First Clinical College of Chinese Medicine, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China;
2.College of Chinese Medicine, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China |
|
|
|
Abstract Atherosclerosis (AS) is a complex disease involving many pathways. The NOX/ROS-NF-κB siginaling pathway plays an important role in the formation of AS, but the mechanism needs to be further clarified. This paper mainly summarizes the NOX/ROS-NF-κB signaling pathway, and elaborates the progress of NOX/ROS-NF-κB signaling pathway in the prevention and treatment of AS, so as to provide reference for follow-up research.
|
|
|
|
|
|
[1] Saigusa R，Winkels H，Ley K. T cell subsets and functions in atherosclerosis [J]. Nat Rev Cardiol，2020，17（7）：387-401.
[2] 安冬青，吴宗贵.动脉粥样硬化中西医结合诊疗专家共识[J].中国全科医学，2017，20（5）：507-511.
[3] 刘言薇，刘中勇.健脾化浊调脂方通过NOX/ROS-NF-κB通路对ox-LDL诱导的血管平滑肌细胞增殖抑制作用研究[J].中华中医药杂志，2018，33（12）：5588-5591.
[4] 刘言薇，刘中勇.调脂Ⅰ号通过NOX/ROS-NF-κB通路对巨噬细胞氧化应激损伤的保护作用[J].时珍国医国药，2019，30（1）：29-32.
[5] 陈昌国，李易，王建飞，等.健脾化浊方通过NOX4/ROS/NF-κB通路调节动脉粥样硬化大鼠主动脉炎症及氧化应激反应的研究[J].中药药理与临床，2019，35（6）：134-139.
[6] 黄琦，刘中勇，刘言薇.健脾化浊调脂方调控NOX/ROS/NF-κB通路对动脉粥样硬化大耳兔的抗氧化应激损伤作用研究[J].时珍国医国药，2020，31（9）：2071-2073.
[7] Lin S，Li X，Zhang J，et al. Omentin-1： Protective impact on ischemic stroke via ameliorating atherosclerosis [J]. Clin Chim Acta，2021，517（6）：31-40.
[8] Guo S，Chen X. The human Nox4：gene，structure，physiological function and pathological significance [J]. J Drug Target，2015，23（10）：888-896.
[9] Ahmadian E，Eftekhari A，Babaei H，et al. Anti-Cancer Effects of Citalopram on Hepatocellular Carcinoma Cells Occur via Cytochrome C Release and the Activation of NF-κB [J]. Anticancer Agents Med Chem，2017，17（11）：1570-1577.
[10] Pires BRB，Silva RCMC，Ferreira GM，et al. NF-kappaB：Two Sides of the Same Coin [J]. Genes（Basel），2018，9（1）：24.
[11] Mitchell JP，Carmody RJ. NF-κB and the Transcriptional Control of Inflammation [J]. Int Rev Cell Mol Biol，2018，335：41-84.
[12] Sun SC. The non-canonical NF-κB pathway in immunity and inflammation [J]. Nat Rev Immunol，2017，17（9）：545-558.
[13] 张文涛，陈云宪，唐良秋.NF-κB信号通路在冠状动脉粥样硬化性心脏病中的作用[J].国际心血管病杂志，2021， 48（1）：28-31.
[14] 王柏森.绿原酸通过抑制TLR4/MAPK/NFκB通路激活自噬抑制炎症和氧化应激[D].吉林：吉林大学，2021.
[15] Fukai T，Ushio-Fukai M. Cross-Talk between NADPH Oxidase and Mitochondria：Role in ROS Signaling and Angiogenesis [J]. Cells，2020，9（8）：1849.
[16] Li W，Xu X，Dong D，et al. Up-regulation of thioredoxin system by puerarin inhibits lipid uptake in macrophages [J]. Free Radic Biol Med，2021，162（1）：542-554.
[17] Li Y，Zhao Q，Cao Y，et al. Probucol decreases homocysteine-stimulated CRP production in rat aortic smooth muscle cells via regulating HO-1/NADPH oxidase/ROS/p38 pathway [J]. Acta Biochim Biophys Sin（Shanghai），2021，53（2）：212-219.
[18] 杨鑫，胡炎伟.氧化低密度脂蛋白在动脉粥样硬化性心血管疾病诊断中的作用[J].中华检验医学杂志，2021， 44（7）：563-568.
[19] Kattoor AJ，Kanuri SH，Mehta JL. Role of Ox-LDL and LOX-1 in Atherogenesis [J]. Curr Med Chem，2019，26（9）：1693-1700.
[20] Luo M，Tian R，Lu N. Quercetin Inhibited Endothelial Dysfunction and Atherosclerosis in Apolipoprotein E-Deficient Mice： Critical Roles for NADPH Oxidase and Heme Oxygenase-1 [J]. J Agric Food Chem，2020，68（39）：10875-10883.
[21] Pejenaute ?譧，Cortés A，Marqués J，et al. NADPH Oxidase Overactivity Underlies Telomere Shortening in Human Atherosclerosis [J]. Int J Mol Sci，2020，21（4）：1434.
[22] 胡文静.NOX/ROS参与PECAM-1调节血管内皮细胞功能对动脉粥样硬化的作用[D].济南：济南大学，2019.
[23] Poznyak AV，Grechko AV，Orekhova VA，et al. NADPH Oxidases and Their Role in Atherosclerosis [J]. Biomedicines，2020，8（7）：206.
[24] Sobey CG，Judkins CP，Rivera J，et al. NOX1 deficiency in apolipoprotein E-knockout mice is associated with elevated plasma lipids and enhanced atherosclerosis [J]. Free Radic Res，2015，49（2）：186-198.
[25] Ouerd S，Idris-Khodja N，Trindade M，et al. Endothelium-restricted endothelin-1 overexpression in type 1 diabetes worsens atherosclerosis and immune cell infiltration via NOX1 [J]. Cardiovasc Res，2021，117（4）：1144-1153.
[26] Wu JH，Zhang L，Nepliouev I，et al. Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation [J]. Cardiovasc Res，2021，118（3），772-784.
[27] Aviram M，Rosenblat M，Etzioni A，et al. Activation of NADPH oxidase required for macrophagemediated oxidation of low-density lipoprotein [J]. Metabolism，1996，45：1069-1079.
[28] Xue S，Tang H，Zhao G，et al. C-C motif ligand 8 promotes atherosclerosis via NADPH oxidase 2/reactive oxygen species-induced endothelial permeability increase [J]. Free Radic Biol Med，2021，167：181-192.
[29] Tian Q，Leung FP，Chen FM，et al. Butyrate protects endothelial function through PPARδ/miR-181b signaling [J]. Pharmacol Res，2021，169：105681.
[30] Yu W，Xiao L，Que Y，et al. Smooth muscle NADPH oxidase 4 promotes angiotensin Ⅱ-induced aortic aneurysm and atherosclerosis by regulating osteopontin [J]. Biochim Biophys Acta Mol Basis Dis，2020，1866（12）：165912.
[31] Lozhkin A，Vendrov AE，Pan H，et al. NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis [J]. J Mol Cell Cardiol，2017，102（1）：10-21.
[32] Kim J，Yoo JY，Suh JM，et al. The flagellin-TLR5-Nox4 axis promotes the migration of smooth muscle cells in atherosclerosis [J]. Exp Mol Med，2019，51（7）：1-13.
[33] Yu W，Li S，Wu H，et al. Endothelial Nox4 dysfunction aggravates atherosclerosis by inducing endoplasmic reticulum stress and soluble epoxide hydrolase [J]. Free Radic Biol Med，2021，164：44-57.
[34] Touyz RM，Anagnostopoulou A，Camargo LL，et al. Vascular biology of superoxide-generating NADPH oxidase 5-implications in hypertension and cardiovascular disease [J]. Antioxid Redox Signal，2019，30（7）：1027-1040.
[35] Bryk D，Olejarz W，Zapolska-Downar D. The role of oxidative stress and NADPH oxidase in the pathogenesis of atherosclerosis [J]. Postepy Hig Med Dosw（Online），2017，71：57-68.
[36] 薛万华，杨婷.氧化应激与自噬在动脉粥样硬化发生发展中的研究进展[J].分子影像学杂志，2019，42（1）：95-98.
[37] Chen SY，Chen YZ，Lee YJ，et al. Maternal hypercholesterolemia exacerbates atherosclerosis lesions in female offspring through potentiating macrophage polarization toward an inflammatory M1 phenotype [J]. J Nutr Biochem，2021，90：108575.
[38] Edgar L，Akbar N，Braithwaite AT，et al. Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis [J]. Circulation，2021，144（12）：961-982.
[39] Jiao L，Jiang M，Liu J，et al. Nuclear factor-kappa B activation inhibits proliferation and promotes apoptosis of vascular smooth muscle cells [J]. Vascular，2018，26（6）：634-640.
[40] 刘峰涛，于紫英.血管平滑肌细胞与动脉粥样硬化斑块稳定性的研究进展[J].中国心血管杂志，2021，26（3）：299-302.
[41] Kong P，Yu Y，Wang L，et al. circ-Sirt1 controls NF-κB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells [J]. Nucleic Acids Res，2019，47（7）：3580-3593.
[42] 张明军.动脉粥样硬化中NF-κB通路与炎症、凋亡及自噬的关联性研究[D].乌鲁木齐：新疆医科大学，2020.
[43] 赵嫦清，王志明，杨丽霞.核因子-κB信号通路与自噬在动脉粥样硬化发生发展中的相互调节作用[J].心脑血管病防治，2019，19（4）：355-357.
[44] 蒋长荣，马小峰.SATB1基因沉默介导NF-κB通路对冠心病小鼠主动脉内皮细胞炎症损伤的保护作用[J].东南大学学报（医学版），2020，39（1）：35-40.
[45] 轩艳，蔡宇，王啸轩，等.牙龈卟啉单胞菌感染对载脂蛋白e基因敲除小鼠动脉粥样硬化的影响[J].北京大学学报（医学版），2020，52（4）：743-749.
[46] Lu S，Luo Y，Zhou P，et al. Ginsenoside compound K protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury via inhibition of nuclear factor-κB，p38，and JNK MAPK pathways [J]. J Ginseng Res，2019，43（1）：95-104.
[47] 冯伟，魏海燕，师艳艳.基于TLR4/NF-κB途径探究左西孟旦调控巨噬细胞极化减轻动脉粥样硬化的作用[J].药物评价研究，2021，44（12）：2578-2586.
[48] 李藤藤.ICA通过调控miR-672-5p/AKT3/NF-κB信号通路抑制ox-LDL诱导的RAW264.7炎症反应[D].吉林：吉林大学，2021.
[49] Tayyeb JZ，Popeijus HE，Mensink RP，et al. Short-Chain Fatty Acids （Except Hexanoic Acid） Lower NF-kB Transactivation，Which Rescues Inflammation-Induced Decreased Apolipoprotein A-I Transcription in HepG2 Cells [J]. Int J Mol Sci，2020，21（14）：5088. |
|
|
|
