基于文献计量的骨关节炎与自噬研究态势分析

doi:10.20047/j.issn1673-7210.2022.24.01

Abstract
Figure/Table
References (30)
Related Citation (15)

Download: PDF (2607 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To discuss the research trend of osteoarthritis (OA) and autophagy, sort out the development history of this field, analyze the current research trends and hotspots, and to make a systematic review and trend prospect of the research in the field of OA and autophagy, so as to provide reference for follow-up research. Methods Based on the PubMed literatures database, bibliometric methods were used to conduct literature analysis and big data mining on OA and autophagy research from January 2011 to December 2021 by the citexs data analysis platform. Results The search obtained 480 valid literatures, and the analysis found that the annual publication volume in this field was increasing continuously, reaching a peak of 108 literatures in 2021, of which the country with the largest number of publications is China (207 literatures, 43.13%), and the research institution was the largest number of publications for the Scripps Research Institute in the United States. The journal with the most literature in this field was Osteoarthritis Cartilage (24 literatures), with a single author publishing up to four literatures, and Chinese scholars had contributed the most in this area. The keywords with the highest frequency in the searched literature were autophagy, apoptosis, chondrocytes, inflammation, and cartilage, and the most associated gene was MTOR (143 literatures). In addition, a total of 15 recommended literatures were also list in this study. Conclusion Research in this field is in a stage of rapid growth, and the research content continues to deepen over time. Although the relevant mechanisms are currently unclear, autophagy as a therapeutic target for OA will have broad clinical prospects, and targeting the complex oxidative stress signaling pathway or regulating MTOR intervention may be an effective way to treat OA.

Key words： Osteoarthritis Autophagy Research situation Bibliometry

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YUAN Changshen1 LI Zhe2 GUAN Yanbing2 LIAO Shuning2 CHEN Lewei2 RONG Weiming2 MEI Qijie1 DUAN Kan1

Cite this article:

YUAN Changshen1 LI Zhe2 GUAN Yanbing2 LIAO Shuning2 CHEN Lewei2 RONG Weiming2 MEI Qijie1 DUAN Kan1. Analysis of the research situation of osteoarthritis and autophagy based on bibliometrics[J]. 中国医药导报, 2022, 19(24): 5-10,21.

URL:

https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.24.01 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I24/5

[1] 中华医学会骨科学分会关节外科学组，中国医师协会骨科医师分会骨关节炎学组，国家老年疾病临床医学研究中心（湘雅医院），等.中国骨关节炎诊疗指南（2021年版）[J].中华骨科杂志，2021，41（18）：1291-1314.
[2] Duan R，Xie H，Liu ZZ. The Role of Autophagy in Osteoarthritis [J]. Front Cell Dev Biol，2020，8：608388.
[3] 曾惠琼，邹玲华，尹志华，等.自噬机制在骨关节炎中的作用[J].中华生物医学工程杂志，2021，27（4）：453-460.
[4] 任全娥.大数据背景下的文献计量学研究进展与学科融合[J].情报理论与实践，2019，42（1）：48-52.
[5] Zheng W，Li X，Liu D，et al. Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy [J]. FASEB J，2019，33（3）：4077-4088.
[6] Nakamura S，Yoshimori T. New insights into autophagosome-lysosome fusion [J]. J Cell Sci，2017，130（7）：1209-1216.
[7] Sokolove J，Lepus CM. Role of inflammation in the pathogenesis of osteoarthritis：latest findings and interpretations [J]. Ther Adv Musculoskelet Dis，2013，5（2）：77-94.
[8] Long C，Yang J，Yang H，et al. Attenuation of renal ischemia/reperfusion injury by oleanolic acid preconditioning via its antioxidant，anti-inflammatory，and anti-apoptotic activities [J]. Mol Med Rep，2016，13（6）：4697-4704.
[9] Kang DG，Lee HJ，Kim KT，et al. Effect of oleanolic acid on the activity，secretion and gene expression of matrix metalloproteinase-3 in articular chondrocytes in vitro and the production of matrix metalloproteinase-3 in vivo [J]. Korean J Physiol Pharmacol，2017，21（2）：197-204.
[10] Yang B，Huang H，He Q，et al. Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes [J]. Evid Based Complement Alternat Med，2021，2021：1905995.
[11] Filomeni G，De Zio D，Cecconi F. Oxidative stress and autophagy：the clash between damage and metabolic needs [J]. Cell Death Differ，2015，22（3）：377-388.
[12] Marchev AS，Dimitrova PA，Burns AJ，et al. Oxidative stress and chronic inflammation in osteoarthritis：can NRF2 counteract these partners in crime? [J]. Ann N Y Acad Sci，2017，1401（1）：114-135.
[13] Lepetsos P，Papavassiliou AG. ROS/oxidative stress signaling in osteoarthritis [J]. Biochim Biophys Acta，2016， 1862（4）：576-591.
[14] Wu J，Yang F，Zhang X，et al. Hydrogen sulfide inhibits endoplasmic reticulum stress through the GRP78/mTOR pathway in rat chondrocytes subjected to oxidative stress [J]. Int J Mol Med，2021，47（4）：34.
[15] Vasheghani F，Zhang Y，Li YH，et al. PPARγ deficiency results in severe，accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage [J]. Ann Rheum Dis，2015，74（3）：569-578.
[16] Zhang Y，Vasheghani F，Li YH，et al. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis [J]. Ann Rheum Dis，2015，74（7）：1432-1440.
[17] Kabeya Y，Mizushima N，Ueno T，et al. LC3，a mammalian homologue of yeast Apg8p，is localized in autophagosome membranes after processing [J]. EMBO J，2000，19（21）：5720-5728.
[18] Valenti MT，Dalle Carbonare L，Zipeto D，et al. Control of the Autophagy Pathway in Osteoarthritis：Key Regulators，Therapeutic Targets and Therapeutic Strategies [J]. Int J Mol Sci，2021，22（5）：2700.
[19] He H，Dang Y，Dai F，et al. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B [J]. J Biol Chem，2003，278（31）：29278-29287.
[20] Satoo K，Noda NN，Kumeta H，et al. The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy [J]. EMBO J，2009，28（9）：1341-1350.
[21] Li Z，Cheng J，Liu J. Baicalin Protects Human OA Chondrocytes Against IL-1β-Induced Apoptosis and ECM Degradation by Activating Autophagy via MiR-766-3p/AIFM1 Axis [J]. Drug Des Devel Ther，2020，14：2645-2655.
[22] Zhao X，Li H，Wang L. MicroRNA-107 regulates autophagy and apoptosis of osteoarthritis chondrocytes by targeting TRAF3 [J]. Int Immunopharmacol，2019，71：181-187.
[23] Li H，Li Z，Pi Y，et al. MicroRNA-375 exacerbates knee osteoarthritis through repressing chondrocyte autophagy by targeting ATG2B [J]. Aging （Albany NY），2020，12（8）：7248-7261.
[24] Zhong G，Long H，Ma S，et al. miRNA-335-5p relieves chondrocyte inflammation by activating autophagy in osteoarthritis [J]. Life Sci，2019，226：164-172.
[25] Lian WS，Ko JY，Wu RW，et al. MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12 [J]. Cell Death Dis，2018，9（9）：919.
[26] Krafczyk N，Klotz LO. FOXO transcription factors in antioxidant defense [J]. IUBMB Life，2022，74（1）：53-61.
[27] Matsuzaki T，Alvarez-Garcia O，Mokuda S，et al. FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis [J]. Sci Transl Med，2018，10（428）：eaan0746.
[28] Zheng G，Zhan Y，Li X，et al. TFEB，a potential therapeutic target for osteoarthritis via autophagy regulation [J]. Cell Death Dis，2018，9（9）：858.
[29] Maimaitijuma T，Yu JH，Ren YL，et al. PHF23 negatively regulates the autophagy of chondrocytes in osteoarthritis [J]. Life Sci，2020，253：117750.
[30] Liao FX，Huang F，Ma WG，et al. The New Role of Sirtuin1 in Human Osteoarthritis Chondrocytes by Regulating Autophagy [J]. Cartilage，2021，13（2_suppl）：1237S-1248S.