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| Investigation and analysis on off-label drug use in Pediatric Outpatient of General Hospital of Ningxia Medical University in 2017 |
| GAO Hua1 BAI Shuoyi2 DENG Ning1 SUN Weihong1 LU Cheng1 LIU Hui1 WEN Youmin1 |
1.Department of Pharmacy, General Hospital of Ningxia Medical University, Ningxia Hui Autonomous Region, Yinchuan 750004, China;
2.Preparation Center, General Hospital of Ningxia Medical University, Ningxia Hui Autonomous Region, Yinchuan 750004, China |
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Abstract Objective To investigate and analyze the situation on off-label drug use for children in Pediatric Outpatient of General Hospital of Ningxia Medical University ("our hospital" for short), in order to provide a reasonable guidence for children medication in clinic. Methods From January to December 2017, Pediatric Outpatient drug prescriptions were selected randomly in our hospital. According to the medicine dispensatory, whether medication orders were over the package insert, the types and medication situation at different ages of off-label drug use, and the correlation between off-label drug use and basic medicine were analyzed. Results A total of 2640 medical prescriptions were selected from the Outpatient Department of Pediatrics, 4293 prescription medication advices were evaluated. According to the prescription and medication orders, the incidence rate of off-label drug use was 11.14% and 7.29% respectively. The main types of off-label drug use were the dosage and frequency of drug delivery, the incidence rates were 4.52% and 1.51% respectively, and the constituent ratios were 61.98% and 20.77% respectively, followed by the indications, the incidence of which was 0.96%, and the constituent ratio was 13.10%. Few references were related with children's medication information and contraindications. According to medication orders, the incidence rate of off-label drug use of the first two patient ages were neonatal (100.00%) and pre-school age (11.24%). The top four drugs of off-label drug use were dermatological drugs (20.00%), vitamin (16.93%), liver protection (13.64%) and digestive system and metabolic drugs (7.96%). Conclusion Due to the phenomenon of off-label drug use in Pediatric Outpatient in our hospital, the clinical pharmacists should pay close attention to the phenomenon and intervene rationally.
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[1] 中国药理学会治疗药物监测研究专业委员会药品风险管理学组.超说明书用药专家共识[J].药物不良反应杂志，2015，17（2）：101-103.
[2] 张伶俐，李幼平.基于风险与责任，促进中国儿童合理用药的思考[J].中国循证医学杂志，2011，11（9）：983-984.
[3] 黄亮，申向黎，陈力，等.正确认识并有效规范超说明书用药行为[J].中国医院药学杂志，2009，29（11）：949-951.
[4] Pandolfini C，Bonati M. A literature review on off-label drug use in children [J]. Eur J Pediatr，2005，164（9）：552-558.
[5] 张伶俐，李幼平，梁毅，等.全球门诊儿童超说明书用药现状的系统评价[J].中国循证医学杂志，2012，12（3）：305-313.
[6] 付文婷，王科燕，宋春莉，等.2012-2014年我院抗肿瘤药物超说明书用药调查分析与合理性评价[J].中国医药导报，2016，13（8）：146-149.
[7] 李亚昙，贾琳，滕亮.国内外儿科超说明书用药近况的系统评价[J].中国医院药学杂志，2016，36（23）：2114-2119.
[8] 何艳玲，祁俊华.2014年我院儿科门诊超说明书用药情况调查[J].儿科药学杂志，2016，22（5）：37-41.
[9] 唐菲菲，范惠霞，赵宇燕.山西省儿童医院儿科门诊超说明书用药调查分析[J].中国药物与临床，2015，15（12）：1717-1721.
[10] 李英，黄琳，于芝颖，等.北京大学人民医院儿科门诊超说明书用药调查与分析[J].中国新药杂志，2014，23（10）：1218-1222.
[11] 李亚昙，阿衣古丽·玉努斯，滕亮.我院儿科门诊超说明书用药调查[J].中国药房，2015，26（32）：4476-4479.
[12] 郭春彦，王晓玲.大型综合儿童医院门诊患儿超说明书用药情况调查[J].临床药物治疗杂志，2014，12（2）：50-55.
[13] Chalumeau M，Tréluyer JM，Salanave B，et al. Off label and unlicensed drug use among French office based pediatricians [J]. Arch Dis Child，2000，83（6）：502-505.
[14] 陈新谦.新编药物学[M].17版.北京：人民卫生出版社，2011：959.
[15] 薛辛东.儿科学[M].北京：人民卫生出版社，2005：302-305.
[16] 张伶俐，李幼平，黄亮，等.四川大学华西第二医院儿科门诊处方超药品说明书用药情况调查[J].中国循证医学杂志，2011，11（10）：1120-1124.
[17] 张伶俐，李幼平，黄亮，等.四川大学华西第二医院2010年儿科门诊患儿超说明书用药情况调查[J].中国循证医学杂志，2012，12（3）：267-273.
[18] 王敏华，王莉.门诊超说明书用药情况分析及管理对策[J].中国现代应用药学，2015，32（5）：634-638.
[19] 中华医学会儿科学分会临床药理学组，《中华儿科杂志》编辑委员会.中国儿科超说明书用药专家共识[J].中华儿科杂志，2016，54（2）：101-103. |
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