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| Prognostic value of serum copeptin combined with Marshall CT classification in infants with craniocerebral trauma |
| YU Xiongwu1 LI Shifu2 DING Zhiyong3 XIONG Liangjun1 LI Chuanfeng4 LI Caifen5 WANG Chaohong5 DONG Yun1 |
1.Department of Pediatric Surgery, Qujing Maternal and Child Health Hospital, Yunnan Province, Qujing 655000, China;
2.General Office, Qujing Maternal and Child Health Hospital, Yunnan Province, Qujing 655000, China;
3.Department of Medical Imaging, Qujing Maternal and Child Health Hospital, Yunnan Province, Qujing 655000, China;
4.Department of Neonatology, Qujing Maternal and Child Health Hospital, Yunnan Province, Qujing 655000, China;
5.Department of Anesthesiology, Qujing Maternal and Child Health Hospital, Yunnan Province, Qujing 655000, China |
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Abstract Objective To explore the prognostic value of serum copeptin combined with Marshall CT classification in infants with craniocerebral trauma. Methods A total of 110 children with craniocerebral trauma treated in Qujing Maternal and Child Health Hospital from February 2018 to June 2020 were selected, they were divided into survival group and death group according to the living condition of 28 days in hospital. The level of serum copeptin were measured between two groups, and the degree of trauma was evaluated by Marshall CT grading. The factors affecting the prognosis of infant craniocerebral trauma and the value of copeptin combined with Marshall CT classification in predicting the prognosis of infant craniocerebral trauma were analyzed. Results There were statistically significant differences in injury type, blood loss, and Glasgow coma scale score between two groups (P < 0.05). The serum copeptin levels and Marshall CT scores of death group were higher than those of survival group, and the differences were statistically significant (P < 0.05). Copeptin and Marshall CT score were influential factors of infant death after traumatic brain injury (OR > 1, P < 0.05). The area under the curve predicted by copeptin combined with Marshall CT score was higher than that predicted by copeptin and Marshall CT score alone (P < 0.05). Conclusion Copeptin and Marshall CT classification have certain value in predicting the prognosis of infant craniocerebral trauma. The combination of two indexes can improve the prediction efficiency.
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[1] 杨艺，何江弘，徐如祥.儿童意识障碍治疗的研究现状及进展[J].中华神经医学杂志，2019，18（6）：644-647.
[2] 赵志杰，孙兆良，陈二涛，等.CT评分系统早期预测创伤性脑损伤患者预后的研究进展[J].中华创伤杂志，2020， 36（10）：956-960.
[3] 向忠豪，陈鑫，陈益磊，等.四种评分系统评价婴幼儿颅脑创伤预后的比较研究[J].中国现代神经疾病杂志，2020， 20（7）：614-619.
[4] 曹成龙，李艳玲，宋健，等.急性中、重型颅脑损伤早期病死率的预测：Marshall CT分级和Rotterdam CT评分的比较[J].中国临床神经外科杂志，2017，22（10）：676-679.
[5] 徐璨，赵敏.和肽素在急诊科危急重症中的应用[J].中国实用内科杂志，2019，39（7）：656-659.
[6] 王建莉，冯一，金国良，等.急性颅脑损伤患者血浆标记物的筛选和临床应用[J].浙江创伤外科，2020，25（5）：824-827.
[7] 尹文国，翁山山，赖仕宇，等.联合GCS评分、CT评分与血清S100B蛋白可评估急性颅脑创伤患者损伤程度及早期预后[J].南方医科大学学报，2021，41（4）：543-548.
[8] 黄欣，温良，王浩，等.Marshall CT分级联合Fisher CT分级在颅脑创伤患者预后评估中的应用[J].浙江创伤外科，2016，21（5）：816-819.
[9] 理国富，邓旺斌，张咏康，等.儿童颅脑损伤的临床特点及治疗体会[J].中国医师杂志，2021，23（5）：772-773.
[10] 李永磊，杨玉升，黄建华，等.颅内压检测及脑脊液乳酸水平对重型颅脑损伤患者预后预测研究[J].创伤外科杂志，2019，21（5）：384-387.
[11] 王小刚，高丁，李涛，等.院前应用格拉斯哥昏迷分级评分评估颅脑损伤患者与预后的相关性分析[J].中国临床医生杂志，2015，43（8）：36-39.
[12] 聂麟，任勇，陈世孝，等.低剂量CT扫描在儿童脑外伤诊断中的价值[J].中华实用诊断与治疗杂志，2018，32（7）：691-693.
[13] 王旭辉，许民辉.问题1：创伤性颅脑损伤外科手术指征[J].创伤外科杂志，2013，15（4）：300.
[14] Chen J，Li M，Zhu X，et al. Atorvastatin reduces cerebral vasospasm and infarction after aneurysmal subarachnoid hemorrhage in elderly Chinese adults[J]. Aging（Albany NY），2020，12（3）：2939-2951.
[15] 马景鑑，刘云阳，李晋，等.弥散张量成像和血清生化指标在急性轻型颅脑损伤评价中的作用[J].中华神经外科杂志，2019，35（2）：172-176.
[16] 郐国虎，蒋伟.血清标记物检测在创伤性颅脑损伤辅助诊断及严重程度评估中的应用研究进展[J].山东医药，2020，60（21）：100-102.
[17] 吕高鹏，臧大维.和肽素对多种疾病的诊断及预后评价研究进展[J].现代临床医学，2017，43（1）：11-14.
[18] 韦有全，黄海清.血管加压素的心血管效应与临床应用研究进展[J].中国医学创新，2018，15（2）：139-144.
[19] 刘丹丹，张洪钿，孙月，等.血清ACA、sTM及Copeptin水平对脑梗死患者神经功能缺损程度的评估价值[J].山东医药，2020，60（1）：68-70.
[20] 彭浩，陈健龙，刘朝晖，等.血清和肽素、MMP-9水平对动脉瘤性蛛网膜下腔出血患者手术治疗预后的预测价值[J].疑难病杂志，2020，19（9）：874-879.
[21] 汪明燕，方素琴，方苏红，等.ICU患者血清和肽素、内毒素、转化生长因子β1表达与其导尿管相关泌尿道感染关系的探讨[J].中国卫生检验杂志，2021，31（6）：715-718.
[22] 张立，艾妮.醒脑静注射液对急性脑梗死患者血清Copeptin、NT-proBNP水平及NIHSS评分的影响[J].河北医药，2016，38（14）：2149-2151.
[23] 王晶，边立衡，王文娟，等.血浆和肽素水平对急性脑出血患者临床结局的预测研究[J].中国卒中杂志，2019， 14（5）：427-431.
[24] 李运平，余国峰，戴伟民，等.急性脑出血患者血浆NT-pro BNP及和肽素与病情严重程度及脑出血量的相关性[J].中国现代医生，2017，55（16）：7-9，12.
[25] 侯丹，余丹，杨国帅.动脉瘤性蛛网膜下腔出血患者血浆和肽素水平与病情严重程度及预后的关系[J].中国临床研究，2019，32（11）：1488-1491. |
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