早期糖尿病肾病患者25-羟维生素D及相关指标水平变化

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Abstract Objective To observe the changes of serum 25-hydroxyvitamin D, Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and urinary albumin creatinine ratio (UACR) in patients with early diabetic nephropathy (DN). Methods A total of 67 patients with early DN who were hospitalized in the Department of Nephrology, the First Affiliated Hospital of Xian Medical University from September to December 2020 were selected as DN group. A total of 74 healthy individuals who underwent physical examination in the First Affiliated Hospital of Xian Medical University during the same period were selected as the control group. The height, body mass index, and blood pressure of each group were collected, and the levels of fasting 25-hydroxyvitamin D, IL-1β and TNF-α, UACR and glucose and lipid metabolism indexes were measured; the relationship between vitamin D and IL-1β, TNF-α, TC, TG, and UACR were analyzed. Results The levels of body mass index, fasting blood glucose and glycosylated hemoglobin in DN group were higher than those in control group, and the differences were statistically significant (P ＜ 0.05). TC, TG, LDL-C and UACR levels in DN group were higher than those in control group, while HDL-C level was lower than control group, the differences were statistically significant (P ＜ 0.05). The level of 25-vitamin D in DN group was lower than that in control group, the difference was statistically significant (P ＜ 0.05). The levels of IL-1β and TNF-α in DN group were higher than those in control group, and the differences were statistically significant (P ＜ 0.05). There was negative correlation between serum 25-hydroxyvitamin D levels and IL-1β, TNF-α level and UACR in DN group (r = -0.647, -0.783, -1.621, P ＜ 0.05). Conclusion The serum 25-hydroxyvitamin D level in patients with early DN is lower than that in normal person, and its level is correlated with inflammatory factors, proteinuria and other risk factors.

Key words： Diabetic nephropathy Vitamin D Inflammatory factors Proteinuria

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	LAN Kai LIU Haoang LIU Shuyi ZHANG Xudong ZHANG Guangwei

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LAN Kai LIU Haoang LIU Shuyi ZHANG Xudong ZHANG Guangwei. Changes of 25-hydroxyvitamin D and its related indexes in patients with early diabetic nephropathy[J]. 中国医药导报, 2022, 19(18): 67-70.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I18/67

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