白细胞分化抗原40配体G基因多态性与老年慢性乙型肝炎后肝硬化相关性及预后的关系

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (631 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the relationship between the G gene polymorphism of leukocyte differentiation antigen 40 ligand (CD40L) and the prognosis of cirrhosis after chronic hepatitis B in the elderly. Methods A total of 82 elderly patients with liver cirrhosis after chronic hepatitis B who were admitted to NO.904 Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army (“our hospital” for short) from May 2016 to March 2019 were selected as the study group, and 80 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. Peripheral venous blood was collected and blood genomic DNA was extracted, the CD40L gene polymorphism was determined, and its genotype distribution was determined. Results The CD40L genotypes of the two groups conformed to Hardy-Weinberg equilibrium law. The G allele frequency of the study group was higher than that of the control group (P ＜ 0.05). The logistic regression model analysis showed that the relative risk of poor prognosis in elderly patients with CG and GG genotypes after chronic hepatitis B was 1.809 times and 2.264 times that of the CC genotype (P ＜ 0.05) . At the end of the one year follow-up, the survival rate of elderly patients with CD40L G gene with liver cirrhosis after chronic hepatitis B was 62.90%. The survival rate of CD40L non-G gene cirrhosis after chronic hepatitis B was 85.00%. There was a statistically significant difference in the mortality curve of CD40L G gene and non-G gene patients (χ2 = 6.138，P ＜ 0.05). Conclusion The frequency of the G allele in elderly patients with post-chronic hepatitis B liver cirrhosis is higher than that in healthy people. The CD40L gene polymorphism is related to the prognosis of death in patients with chronic hepatitis B after cirrhosis. The GG and CG genotypes can increase the risk of death.

Key words： Elderly Leukocyte differentiation antigen 40 ligand Gene polymorphism Chronic hepatitis B Liver cirrhosis Prognosis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	FAN Baihua1 LU Xiaoyi2▲

Cite this article:

FAN Baihua1 LU Xiaoyi2▲. Relationship between leukocyte differentiation antigen 40 ligand G gene polymorphism and the correlation and prognosis of cirrhosis after chronic hepatitis B in the elderly[J]. 中国医药导报, 2022, 19(17): 147-150.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I17/147

[1] Tang LSY，Covert E，Wilson E，et al. Chronic Hepatitis B Infection：A Review [J]. JAMA，2018，319（17）：1802-1813.
[2] Kanda T，Goto T，Hirotsu Y，et al. Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections：A Review [J]. Int J Mol Sci，2019，20（6）：1358.
[3] Aarts S，Reiche M，den Toom M，et al. Depletion of CD40 on CD11c（+） cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH [J]. Sci Rep，2019，9（1）：702-706.
[4] 刘琳，张玮，罗晓光，等.中国东北地区CD40及CD40L基因多态性与散发帕金森病的相关性分析[J].中风与神经疾病杂志，2019，36（4）：331-334.
[5] Putlyaeva LV，Demin DE，Korneev KV，et al. Potential Markers of Autoimmune Diseases，Alleles rs115662534（T） and rs548231435（C），Disrupt the Binding of Transcription Factors STAT1 and EBF1 to the Regulatory Elements of Human CD40 Gene [J]. Biochemistry，2018，83（12）：1534-1542.
[6] 科技部十二五重大专项联合课题组专家.乙型肝炎病毒相关肝硬化的临床诊断、评估和抗病毒治疗的综合管理[J].临床肝胆病杂志，2014，30（2）：99-108.
[7] Zhao RH，Shi Y，Zhao H，et al. Acute-on-chronic liver failure in chronic hepatitis B：an update [J]. Expert Rev Gastroenterol Hepatol，2018，12（4）：341-350.
[8] Ramroodi N，Saboori H，Sanadgol N. Investigation of association between CD40 current gene variants （rs4810485，rs1883832 and rs3765459） and serum CD154 protein levels in Iranian migraineurs [J]. Cell Mol Biol，2018，64（14）：72-78.
[9] Bae SC，Lee YH. Association between CD40 polymorphisms and systemic lupus erythematosus and correlation between soluble CD40 and CD40 ligand levels in the disease：a meta-analysis [J]. Lupus，2019，28（12）：1452-1459.
[10] Kanda T，Goto T，Hirotsu Y，et al. Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections：A Review [J]. Int J Mol Sci，2019，20（6）：23-26.
[11] Le AK，Yang HI，Yeh ML，et al. Development and Validation of a Risk Score for Liver Cirrhosis Prediction in Untreated and Treated Chronic Hepatitis B [J]. J Infect Dis，2021，223（1）：139-146.
[12] Reiche ME，den Toom M，Willemsen L，et al. Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction [J]. BMJ Open Diabetes Res Care，2019，7（1）：829-832.
[13] 严志凌，杨谢兰，张红平，等.云南汉族人群CD40基因多态性与宫颈癌的相关性研究[J].中华肿瘤防治杂志，2017，24（19）：7-10，17.
[14] Raabe O，Birchler T，Rehrauer H，et al. CD40 Agonist Monoclonal Antibody-Mediated Hepatitis in TNF-Receptor 1 Gene Knockout Mice[J]. Biomedicines，2021，9（8）：32-35.
[15] Martínez-Fernández DE，Padilla-Gutiérrez JR，Casillas-Mu?觡oz F，et al. Analysis of Genetic Variation in CD40 and CD40L： Relationship with mRNA Relative Expression and Soluble Proteins in Acute Coronary Syndrome[J]. J Immunol Res，2019，12（6）：217-223.
[16] 刘琳，张玮，罗晓光，等.中国东北地区CD40及CD40L基因多态性与散发帕金森病的相关性分析[J].中风与神经疾病杂志，2019，36（4）：331-334.
[17] Sarmiento L，Svensson J，Barchetta I，et al. Copy number of the X-linked genes TLR7 and CD40L influences innate and adaptive immune responses [J]. Scand J Immunol，2019，90（2）：171-176.
[18] Mousa TG，Omar HH，Emad R，et al. The association of CD40 polymorphism （rs1883832C/T） and soluble CD40 with the risk of systemic lupus erythematosus among Egyptian patients [J]. Clin Rheumatol，2019，38（3）：777-784.
[19] Aarts S，Reiche ME，den Toom M，et al. Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction [J]. PLoS One，2018，13（8）：150-153.
[20] 陈乐，戴佳琳，张琼，等.CD40基因RS1535045多态性与冠心病及其所致猝死的关联性[J].临床心血管病杂志，2020，36（4）：347-351.
[21] 吴应冬，周宝勤，谢群，等.TNF-α，CD40基因多态性与乙肝肝硬化的相关性研究[J].国际检验医学杂志，2019， 40（18）：45-48.
[22] Sultan CS，Weitnauer M，Turinsky M，et al. Functional association of a CD40 gene single-nucleotide polymorphism with the pathogenesis of coronary heart disease [J]. Cardiovasc Res，2020，116（6）：1214-1225.
[23] Laman JD，Claassen E，Noelle RJ. Functions of CD40 and Its Ligand，gp39 （CD40L）[J]. Crit Rev Immunol，2017，37（2/6）：371-420.
[24] Rachakonda SP，Dai H，Penack O，et al. Single Nucleotide Polymorphisms in CD40L Predict Endothelial Complications and Mortality After Allogeneic Stem-Cell Transplantation [J]. J Clin Oncol，2018，36（8）：789-800.
[25] Aarts S，Seijkens T，van Dorst K，et al. The CD40-CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis[J]. Front Immunol，2017，8（5）：91-95.