不同手术入路甲状腺根治术治疗分化型甲状腺癌患者的安全性及预后观察

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Abstract Objective To observe the safety and prognosis of patients with differentiated thyroid cancer treated by radical thyroidectomy with different operation approaches. Methods Eighty-four patients with differentiated thyroid cancer admitted to Rugao Hospital Affiliated to Nantong University from January 2018 to December 2020 were selected, they were divided into control group and observation group by random number table method, with 42 cases in each group. The observation group was treated with modified Miccoli operation, and the control group was treated with radical thyroidectomy via areola approach. Perioperative indicators, visual analogue scale (VAS), European Organization for Research and treatment of cancer quality of life questionnaire (EORTC QLQ-C30) score, and postoperative complications were recorded. Results The operation time, hospital stay time, and neck recovery time in the observation group were shorter than those in the control group, and the intraoperative blood loss and postoperative drainage volume were smaller than those in the control group, with statistically significant differences (P ＜ 0.05). Overall analysis showed that VAS score of two groups had statistical significance in time, between groups, and interaction (P ＜ 0.05). Further pairwise comparison, intra-group comparison: VAS scores of both groups at 72 h after surgery were higher than those before surgery and 12, 24, and 48 h after surgery, with statistically significant differences (P ＜ 0.05). Comparison between groups: VAS score of the observation group was lower than that of the control group at 12 and 24 h after surgery, and the differences were statistically significant (P ＜ 0.05). One month after surgery, QLQ-C30 scores in both groups were higher than those before surgery, and physical function, emotional function, social function, and overall health scores in observation group were higher than those in control group, and the differences were statistically significant (P ＜ 0.05). There was no significant difference in the total incidence of postoperative complications between the two groups (P ＞ 0.05). Conclusion Modified Miccoli operation treatment for differentiated thyroid cancer patients can reduce intraoperative blood loss and postoperative drainage volume, reduce patients’ recovery time and hospital stay time, improve patients’ prognosis, and have high safety, which is worthy of promotion.

Key words： Differentiated thyroid carcinoma Endoscopic surgery Modified Miccoli procedure Safety Prognosis

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	YUAN Xiaobing1 CHEN Weiwei1 LIU Xiaoli2 WU Pengfei1

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YUAN Xiaobing1 CHEN Weiwei1 LIU Xiaoli2 WU Pengfei1. Safety and prognosis observation of patients with different operation approaches for the treatment of differentiated thyroid cancer by radical thyroidectomy[J]. 中国医药导报, 2022, 19(17): 131-134,162.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I17/131

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