胃癌组织中lncRNA UCA1、miR-590-3p表达及与病理参数和预后的关系

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Abstract Objective To investigate the expression of long non-coding RNA (lncRNA) urothelial cancer associated 1 (UCA1) and microRNA (miR)-590-3p in gastric cancer tissues and the relationship with pathological parameters and prognosis. Methods A total of 107 case of gastric cancer patients admitted to Tangshan Hospital of Traditional Chinese Medicine of Hebei Province from January 2017 to July 2018 were selected, and lncRNA UCA1, miR-590-3p expression were detected in cancer and cancer-adjacent tissues by qRT-PCR. The correlation between lncRNA UCA1 and miR-590-3p expression in gastric cancer tissues and the relationship with pathological parameters were analysed. Survival curves of patients with different lncRNA UCA1, miR-590-3p expression in gastric cancer were plotted using the K-M method. Results The expression of lncRNA UCA1 in gastric cancer tissues was higher than that in cancer-adjacent tissues, and the expression of miR-590-3p was lower than that in cancer-adjacent tissues (P ＜ 0.05). Pearson correlation analysis showed that lncRNA UCA1 was negatively correlated with miR-590-3p expression in gastric cancer tissues (r = -0.720, P ＜ 0.01). The expression of lncRNA UCA1 and miR-590-3p in patients with different clinicopathological stages and with or without lymph node metastasis was significantly different (P ＜ 0.05). K-M survival curve showed that the cumulative survival rate of high lncRNA UCA1 expression group was lower than that of low lncRNA UCA1 expression group, and the cumulative survival rate of high miR-590-3p expression group was higher than that of low miR-590-3p expression group (χ2=8.140, 11.624; P = 0.004, 0.001). Conclusion High expression of lncRNA UCA1 and low expression of miR-590-3p in gastric cancer tissues are associated with clinicopathological stages, lymph node metastasis, and prognosis, and may be used as indicators for prognostic assessment.

Key words： Gastric cancer Long non-coding RNA Urothelial cancer associated 1 MicroRNA-590-3p Prognosis

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	LI Yanmei1 LI Wei2 WANG Haiqin1

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LI Yanmei1 LI Wei2 WANG Haiqin1. Expression of lncRNA UCA1, miR-590-3p in gastric cancer tissues and the relationship with pathological parameters and prognosis[J]. 中国医药导报, 2022, 19(17): 127-130.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I17/127

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