尿FSP-1、β2-MG与过敏性紫癜患儿病情严重程度的关系及预后影响因素分析

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Abstract Objective To investigate the severity of urinary fibroblast marker protein-1 (FSP-1), β2-microglobulin (β2-MG) of children with henoch-schonlein purpura (HSP) and the factors affecting prognosis. Methods From January 2018 to December 2020, 110 children with HSP admitted to the Department of Pediatrics, the First Affiliated Hospital of Anhui University of Science and Technology (“our hospital” for short) were selected as HSP group. During the same period, 100 healthy children who came to our hospital for health consultation were control group. The levels of urinary FSP-1 and β2-MG were compared between two groups, and the correlation between the levels and purpura symptoms scores was analyzed. The children were divided into kidney injury group and non-injury group according to whether kidney injury occurred within one week after admission, and the risk factors influencing poor prognosis of HSP were analyzed. Results The levels of urinary FSP-1 and β2-MG in HSP group were higher than those in control group, and the differences were statistically significant (P ＜ 0.05). Pearson correlation analysis showed that urinary FSP-1 and β2-MG levels were positively correlated with purpura symptom scores (r ＞ 0, P ＜ 0.05). There were 35 cases of renal injury in 110 cases, and there were statistically significant differences in abdominal pain, IgA, urinary FSP-1, urinary β2-MG, and purpura symptom scores between two groups (P < 0.05). Logistic regression analysis showed that abdominal pain, IgA, urinary FSP-1, β2-MG, and purpura symptom score were the effect factors for poor prognosis (OR > 1, P < 0.05). Conclusion Abnormal levels of urinary FSP-1 and β2-MG in children with HSP and positively correlated with the severity of the disease, which are risk factors leading to poor prognosis.

Key words： Fibroblast marker protein 1 β2-microglobulin Henoch-schonlein purpura Kidney injury

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	WANG Liang LI Yanling ZHANG Wenhua

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WANG Liang LI Yanling ZHANG Wenhua. Relationship between urinary FSP-1, β2-MG and severity of henoch-schonlein purpura in children and prognosis factors analysis[J]. 中国医药导报, 2022, 19(17): 104-107.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I17/104

[1] 王靖.从瘀论治过敏性紫癜肾炎初探[J].中国中西医结合急救杂志，2019，26（4）：507-509.
[2] 盛晓笑，翟亚玲，陈雅卓，等.伴贫血过敏性紫癜肾炎患者的临床特点及预后研究[J].中国全科医学，2021，24（29）：3692-3698.
[3] Kurnia B. Henoch-schonlein purpura in children：The role of corticosteroids [J]. Open Access Maced J Med Sci，2019，7（11）：1812-1814.
[4] 傅娟，周燕，刘小香.血和尿中生化指标检测在老年原发性高血压患者早期肾损伤诊断中的意义[J].中国卫生检验杂志，2019，29（7）：816-817，822.
[5] Griffin BR，Faubel S，Edelstein CL. Biomarkers of drug-induced kidney toxicity [J]. Ther Drug Monit，2019，41（2）：213-226.
[6] 张圆圆.血管紧张素Ⅱ和12-脂氧化酶的相互作用对2型糖尿病肾病蛋白尿影响的机制研究[D].长春：吉林大学，2015.
[7] 蔡晓盛，池琼，吴建华，等.不同COPD分级患者肾损伤及炎症因子的相关性研究[J].重庆医学，2020，49（4）：614-618.
[8] Liang M，Guo Q，Huang F，et al. Notch signaling in bone marrow-derived FSP-1 cells initiates neointima formation in arteriovenous fistulas [J]. Kidney Int，2019，95（6）：1347-1358.
[9] 周敏，薛文翠，李霞，等.高血压肾损伤早期诊断实验室检测指标的选择[J].现代仪器与医疗，2019，25（1）：41-44.
[10] 中华医学会儿科学分会免疫学组，《中华儿科学》编辑委员会.2013儿童过敏性紫癜询证诊治建议[J].中华儿科杂志，2013，51（7）：502-507.
[11] Fessatou S，Nicolaidou P，Gourgiotis D，et al. Endothelin 1 levels in relation to clinical presentation and outcome of Henoch Schonlein purpura [J]. BMC Pediatr，2008，8：33.
[12] 吴云刚，何方.过敏性紫癜患儿发生肾脏损害危险因素的Logistic回归分析[J].中国中西医结合皮肤性病学杂志，2019，18（5）：397-400.
[13] 吴淑芬，吴芳，杨跃红，等.儿童紫癜性肾炎血尿酸水平与临床及病理的关系[J].临床儿科杂志，2020，38（6）：406-409.
[14] 康志娟，刘波，李志辉，等.半乳糖缺陷IgA1在儿童紫癜性肾炎早期诊断中的意义[J].中国当代儿科杂志，2019， 21（2）：172-175.
[15] 王晓磊，田年秀，韩哲吉，等.芪卫颗粒改善TGF-β1诱导的肾小球足细胞转分化的作用研究[J].环球中医药，2018，11（11）：13-17.
[16] 张盈莹，卓永，欧佩，等.尿NGAL及KIM-1水平对藏区糖尿病肾脏病的临床诊断价值研究[J].国际内分泌代谢杂志，2020，40（5）：294-299.
[17] Zhu FQ，Chen MJ，Zhu M，et al. Curcumin suppresses epithelial-mesenchymal transition of renal tubular epithelial cells through the inhibition of Akt/mTOR pathway [J]. Biol Pharm Bull，2017，40（1）：17-24.
[18] 白志勋，陆静，杨亦彬.TGF-β1/ILK/FSP1信号通路在环孢素诱导肾小管上皮细胞转分化中的作用[J].南方医科大学学报，2019，39（7）：804-809.
[19] 马一飞，李玉峰，郭桂梅，等.新型尿液标志物在紫癜性肾炎患儿中的水平变化[J].上海交通大学学报（医学版），2020，40（6）：841-846.
[20] 戴恩来，陈凤，刘一帆.槲皮素对阿霉素致大鼠肾小球硬化的干预作用[J].中国中西医结合肾病杂志，2019， 20（2）：101-104.
[21] Morikawa Y，Takahashi N，Kamiyama K，et al. Elevated levels of urinary extracellular vesicle fibroblast-specific protein 1 in patients with active crescentic glomerulonephritis [J]. Nephron，2019，141（3）：177-187.
[22] 卢海洋，宁新宇，陈瑛琪，等.血β2-微球蛋白在肝移植急性肾损伤的判断价值[J].临床和实验医学杂志，2021， 20（15）：1621-1624.
[23] 梁翩燕.糖尿病早期肾损伤诊断中B2微球蛋白、血糖联合检验的临床价值分析[J].临床检验杂志（电子版），2019，8（1）：158-159.
[24] 丁元.积雪草颗粒对TGFβ1诱导的体外培养的肾小管上皮细胞E-cadherin、FSP-1、FN表达的研究[D].郑州：河南中医药大学，2016.
[25] 韩才淯，郭珲，罗静.多发性骨髓瘤合并肾损伤的临床分析[J].中国中西医结合肾病杂志，2019，20（12）：1086-1088.
[26] 张洪利.二丁二仙汤对脾肾两虚型慢性肾盂肾炎患者尿NAG、β2-MG及免疫功能的影响[J].现代中西医结合杂志，2018，27（8）：856-859.
[27] 韩林珊，董丹.他克莫司联合环磷酰胺冲击治疗儿童激素依赖型肾病综合征的临床效果[J].中国当代医药，2021，28（16）：138-141.
[28] 周琪，钱光荣，唐晓飞. 低钙透析联合HFHD对维持性血液透析的效果及对钙磷代谢的影响[J].中国医药导报，2021，18（10）：100-103.