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| Serum levels of vitamin A, 25-hydroxyvitamin D3， and vitamin E in children with primary development delay and their correlation with neurodevelopment |
| ZHANG Fan1 TANG Xin2 ZHANG Min3 ZHU Yike4 LIU Siqi1 REN Yongying1 WANG Xin1 WANG Lin4 YANG Jian1#br# |
1.Department of Neurology, Children’s Hospital, Capital Institute of Pediatrics, Beijing 100020, China;
2.Department of Pediatrics, the First Affiliated Hospital of Air Force Military Medical University of Chinese People’s Liberation Army, Shaanxi Province, Xi’an 710032, China;
3.Department of Biochemistry and Immunology, Capital Institute of Pediatrics, Beijing 100020, China;
4.Department of Child Health, Children’s Hospital, Capital Institute of Pediatrics, Beijing 100020, China |
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Abstract
[Abstract] Objective To preliminarily analyse the serum levels of vitamin A, 25-hydroxy-vitamin D3, and vitamin E in children with primary development delay (DD) and their correlation with neurodevelopment. Methods Thirty-three children with primary DD who were treated in the Department of Neurology, Children’s Hospital, Capital Institute of Pediatrics (hereinafter referred to as “our hospital”) from March 2019 to February 2020 were selected as primary DD group, and 30 children who underwent routine physical examinations in the Department of Child Health during the same period served as healthy control group. The serum level of vitamin A, 25-hydroxy-vitamin D3, and vitamin E of two groups were measuerd by high performance liquid chromatography tandem mass spectrometry. The neurodevelopmental level of children with primary DD was evaluated by developmental scale for children aged 0-6 years, and the correlation between the scores of each functional area and vitamin content was analyzed. Results The serum level of vitamin A and 25-hydroxy-vitamin D3 in primary DD group were lower than those in healthy control group (P < 0.05). There was no significant difference in serum vitamin E content between two groups (P > 0.05). The deficiency rates of vitamin A, 25-hydroxyvitamin D3, and vitamin E in primary DD group were higher than those in healthy control group (P < 0.05). The level of 25-hydroxy-vitamin D3 was positively correlated with the score in the fine motion dimension (r = 0.375, P < 0.05). Vitamin A and 25-hydroxy-vitamin D3 were protective factors for primary DD (OR ＜ 1, P < 0.05). Conclusion The serum levels of vitamin A and 25-hydroxy-vitamin D3 in primary DD children are significantly lower than those of healthy children of the same age, serum 25-hydroxy-vitamin D3 deficiency affects fine motor development in children.
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