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| Changes and clinical value of serum inflammatory factors in patients with enlarged perivascular space in basal ganglia region |
| HAO Guang1 SHI Yongxing2 CHANG Qing1 WANG Gang1 XUE Qian1 ZOU Yu’an1 |
1.Department of Endocrinology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Department of Ultrasound Medicine, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China |
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Abstract Objective To explore the changes and clinical value of serum inflammatory factors in patients with enlarged perivascular space (EPVS) in basal ganglia region. Methods A total of 60 patients admitted to the Department of Neurology, the First Affiliated Hospital of Hebei North University (hereinafter referred to as “our hospital”) from March 2018 to March 2019 with EPVS detected by cranial magnetic resonance imaging were selected as the EPVS group, and 30 healthy subjects in our hospital during the same period were selected as the control group. The serum levels of interleukin (IL)-1, IL-6, tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) were compared between the two groups. The differences of IL-1, IL-6, TNF-α, and CRP in patients with different EPVS grades were further compared. The diagnostic value of IL-1, IL-6, TNF-α, and CRP for EPVS in basal ganglia region was analyzed by receiver operating characteristic curve and area under curve (AUC). Results Serum IL-1, IL-6, TNF-α, and CRP levels in EPVS group were higher than those in control group, the differences were statistically significant (P ＜ 0.05). The serum levels of IL-1, IL-6, TNF-α, and CRP in patients with grade two and three EPVS in basal ganglia region were higher than those in patients with grade one EPVS in basal ganglia region, and the serum levels of IL-1, IL-6, TNF-α, and CRP in patients with grade three EPVS in basal ganglia region were higher than those in patients with grade two EPVS in basal ganglia region, the differences were statistically significant (P ＜ 0.05). Serum IL-1, IL-6, TNF-α, and CRP had diagnostic value for EPVS in basal ganglia region alone or in combination datection (AUC ＞ 0.05, P ＜ 0.05). Conclusion The serum levels of IL-1, IL-6, TNF-α, and CRP in patients with EPVS in the basal ganglia region are abnormally elevated. Combined detection of the above serological indicators could help improve the diagnosis rate of EPVS in the basal ganglia region and provide scientific reference for clinical treatment.
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