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| Effects of mild hypothermia combined with hyperbaric oxygen on cognitive function in patients with delayed encephalopathy due to carbon monoxide poisoning |
| ZHANG Mingming1 ZHANG Yingqi1 CHEN Ying1 ZHANG Bin1 JI Wenqiang1 ZHANG Sui2 |
1.Department of Emergency, the First Hospital of Hebei Medical University, Hebei Province, Shijiazhuang 050031, China;
2.Department of Liver Disease Center, the First Hospital of Hebei Medical University, Hebei Province, Shijiazhuang 050031, China |
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Abstract Objective To observe the effects of mild hypothermia combined with hyperbaric oxygen therapy on neuron specific enolase (NSE), S100β, and cognitive function in patients with delayed encephalopathy due to carbon monoxide poisoning (DEACMP). Methods A total of 70 patients with DEACMP who were admitted to the Department of Emergency of the First Hospital of Hebei Medical University from October 2018 to December 2020 were selected and divided into observation group and control group according to the random number table method, with 35 cases in each group. Both groups were given neurotrophic, free radical scavenging, and symptomatic treatment, the control group was given hyperbaric oxygen therapy, while the observation group was given mild hypothermia + hyperbaric oxygen therapy. The curative effect of the two groups was evaluated, and the changes of NSE, S100β levels, cognitive function, and daily living ability were observed before and after treatment in the two groups. Results After three months of treatment, the total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, NSE and S100β in the two groups were lower than those before treatment, while those of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The scores of the mini-mental state examination scale and the abilities of daily living scale in the two groups after treatment were higher than those before treatment, those of the observation group were higher than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Mild hypothermia combined with hyperbaric oxygen therapy for DEACMP can effectively protect brain cell damage, improve patients’ cognitive function and daily living ability, enhance their quality of life, promote patients’ recovery, and improve prognosis, which is worthy of clinical application.
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