活血膏联合中药熏药治疗膝关节骨性关节炎的效果及对IL-1β、MMP-9的影响

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Abstract Objective To analyze the effect of Huoxue Ointment combined with herbal fumigation in the treatment of knee osteoarthritis (KOA) and its influence on interleukin-1 beta (IL-1β) and matrix metalloproteinase (MMP-9). Methods Ninety-two patients with KOA admitted to the People′s Hospital of Liuzhou City of Guangxi Zhuang Autonomous Region from September 2015 to August 2017 were selected and randomly divided into the control group and the observation group by envelope method, with 46 cases in each group. The control group was treated with self-made Huoxue Ointment applicator therapy, and the observation group was treated with Huoxue Ointment and Chinese herbal fumigation. After continuous treatment for 2 weeks, the differences of curative effect, levels of IL-1β and MMP-9, visual analogue scale (VAS) score, hospital specialsurgery (HSS) knee score, short form 36 questionnaire (SF-36) score and adverse reactions between the two groups were compared. Results After treatment, the total effective rate of observation group (97.83%) was higher than that of the control group (84.78%), there was a statistically significant difference between the two groups (P ＜ 0.05). After treatment, the levels of serum IL-1 and MMP-9 of the two groups were significantly lower than those before treatment, and the levels of IL-1 and MMP-9 in the observation group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the VAS scores of the two groups were all lower than those before treatment, while the HSS scores and SF-36 scores of the two groups were all higher than those before treatment, the differences were statistically significant (P ＜ 0.05), and the VAS score of observation group was lower than that of control group, the HSS score and SF-36 score were higher than those of control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups during the treatment period (P ＞ 0.05). Conclusion Combined application of Huoxue Ointment and herbal fumigation in the treatment of knee osteoarthritis has satisfactory curative effect, which can effectively decrease the levels of serum inflammatory factors, reduce the pain, improve the knee joint activities and quality of life.

Key words： Huoxue Ointment Herbal fumigation Knee osteoarthritis Interleukin-1β Matrix metalloproteinase

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	ZHOU Wei ZHENG Hongbo FENG Sui LIU Qiang LI Yongwen

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ZHOU Wei ZHENG Hongbo FENG Sui LIU Qiang LI Yongwen. Effect of Huoxue Ointment combined with herbal fumigation in the treatment of knee osteoarthritis and its influence on IL-1β and MMP-9[J]. 中国医药导报, 2018, 15(27): 117-121.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I27/117

[1] 翟艳萍，安丙辰，郑洁皎，等.膝骨关节炎患者膝关节失稳的研究进展[J].中华物理医学与康复杂志，2017，39（1）：76-78.
[2] 郑斌，梅伟，魏成建，等.中医治疗膝骨关节炎研究进展[J].湖北中医药大学学报，2016，18（2）：114-117.
[3] 中华医学会风湿病学分会. 骨关节炎诊断及治疗指南[J].中华风湿病学杂志，2010，14（6）：416-419.
[4] 中华人民共和国卫生部.中药新药临床研究指导原则[S].北京：中国医药科技出版社，2002：350-353.
[5] 中国中医药研究促进会骨科专业委员会，中国中西医结合学会骨伤科专业委员会关节工作委员会.膝骨关节炎中医诊疗专家共识（2015年版）[J].中医正骨，2015，27（7）：4-5.
[6] 李华，方志远，柏立群，等.中药外敷法对轻中度膝关节骨性关节炎WOMAC评分和VAS评分的影响[J].世界中医药，2017，12（4）：803-806.
[7] 彭颂，胥伯勇，曹力，等.单髁置换与全膝置换患者膝关节评分的比较：随机对照试验[J].中国组织工程研究，2015，22（48）：7724-7730.
[8] 李宁秀，刘朝杰，李俊，等.四川省城乡居民SF-36评价参考值[J].华西医科大学学报，2001，32（1）：43-47.
[9] 任燕，石娅娅，谭波，等.中国人群膝骨关节炎危险因素的Meta分析[J].现代预防医学，2015，42（12）：2282-2284， 2292.
[10] Bloecker K，Wirth W，Guermazi A，et al. Longitudinal change in quantitative meniscus measurements in knee osteoarthritis-data from the Osteoarthritis Initiative [J]. European radiology，2015，25（10）：2960-2968.
[11] 骆家伟，方斌.透明质酸对膝骨关节炎患者关节液中脂联素和瘦素水平的影响[J].中华关节外科杂志：电子版，2015，9（1）：55-59.
[12] 王海东，年芳红，金芳梅，等.祖师麻膏药治疗寒湿痹阻型类风湿关节炎腕关节病变40例[J].西部中医药，2016， 29（10）：107-109.
[13] 闫飞鸿，程春生，程真真，等.中药熏洗联合舒筋活血祛痛膏贴敷治疗跗间关节骨关节炎临床观察[J].风湿病与关节炎，2016，5（2）：8-10，20.
[14] 朱文虎，陈国平.全膝关节置换术结合活血利湿汤治疗膝关节骨性关节炎的临床观察[J].中国社区医师，2017， 33（29）：80-81.
[15] 张玉龙.活血通痹汤联合运动疗法治疗早中期膝关节骨性关节炎近期疗效观察[J].山西中医，2017，33（2）：41-42.
[16] 王晓敏，赖震，包晓萍，等.中药熏蒸联合玻璃酸钠关节注射治疗老年膝骨性关节炎的疗效观察[J].中华物理医学与康复杂志，2017，39（2）：152-153.
[17] 罗彬.活血生骨汤在膝关节骨性关节炎中的应用[J].中西医结合心血管病电子杂志，2017，5（21）：198.
[18] 朱鑫鑫，沈金明.玻璃酸钠联合复方倍他米松注射液治疗膝关节骨性关节炎的临床疗效观察[J].中国现代医生，2018，56（6）：90-93.
[19] 梅鸥，刘敏.热敏灸配合补肾强骨方治疗膝关节骨性关节炎的效果及对炎性因子的影响[J].中国当代医药，2017，24（34）：68-70.
[20] ?覫iestad BE，Juhl CB，Eitzen I，et al. Knee extensor muscle weakness is a risk factor for development of knee osteoarthritis. A systematic review and meta-analysis [J]. Osteoarthritis Cartilage，2015，23（2）：171-177.
[21] 李瑞山，刘永明，何风春，等.关节镜下有限清理、微骨折处理及臭氧注射治疗膝关节骨性关节炎的疗效观察[J].现代医院，2016，16（3）：354-355.
[22] 庞显伦，杨健，秦昊，等.人工关节炎性介质对滑膜细胞基质金属蛋白酶-9表达的影响[J].中华实验外科杂志，2016，33（4）：1052-1054.
[23] 杨举，李宏涛，郭勇，等.冰红消肿膏配合定点运穴推拿治疗膝骨关节炎的疗效观察[J].中国现代医生，2017， 55（25）：26-29.
[24] 曲震，庞瑞明，陈晓青，等.黄柏骨伤散外用治疗膝关节炎气滞血瘀型的临床研究[J].中国当代医药，2017，24（36）：117-119.
[25] 闫秀清，王芳芳，葛风梅，等.甲氨蝶呤时间治疗学在胶原诱导性关节炎大鼠中的实验研究[J].中华风湿病学杂志，2016，20（5）：325-330，封3.
[26] 张引红，李美宁，王春芳，等.补骨脂素对类风湿性关节炎小鼠模型的免疫调节作用[J].中国实验动物学报，2017， 25（2）：207-210.
[27] 周亚欧，龚震，李通，等.高迁移率族蛋白1联合白细胞介素-1β及脂多糖对类风湿关节炎患者成纤维样滑膜细胞增殖及炎症因子分泌的影响[J].中华风湿病学杂志，2016，20（7）：437-440.