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| Efficacy of Finasteride in the treatment of castration resistant prostate cancer |
| ZHAO Qiyue ZENG Siping |
| Department of Urology, Liuzhou Worker′s Hospital, Guangxi Zhuang Autonomous Region, Liuzhou 545007, China |
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Abstract Objective To study and discuss the efficacy of Finasteride in the treatment of castration resistant prostate cancer. Methods Clinical data of 72 patients with castrated resistant prostate cancer admitted to Liuzhou Worker's Hospital from January 2010 to January 2016 were collected to study retrospectively. They were divided into control group (Flutamide treatment group) and observation group (Flutamide and Finasteride treatment) according to different treatment therapy, with 36 cases in each group. Clinical efficacy, changes of urodynamics (MFR, UFR and PVR), serum prostate specific antigen (PSA), volume of prostate and tumor were compared between the two groups. And the PSA progression-free survival time, total survival time, quality of life score and adverse reaction were also compared between the two groups. Results Six months after treatment, the effective rate of the observation group was higher than that of the control group (72.2%) (P ＜ 0.05). The reductions of MFR, UFR and PVR of the observation group were higher than those of the control group (P ＜ 0.05). The PSA level of the two groups significantly declined (P ＜ 0.05), and the lowest PSA level in the observation group was lower than that in the control group (P ＜ 0.05). The proportion of patients with normal PSA level in the observation group was significantly higher than that in the control group (P ＜ 0.01). The prostate and tumor volume in the observation group were smaller than those in the control group (P ＜ 0.01). Followed up for 6-24 months, survival analysis showed that the median PSA progression-free survival and total survival time of the observation group were longer than those in the control group (P ＜ 0.05). The scores of quality of life in the observation group were higher than those of the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion The effect of Finasteride is significant in the patients with castration resistant prostate cancer. It can obviously improve the urodynamics and PSA level, inhibit the development of tumor, and prolong the survival time and improve quality of life.
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