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Research progress of drug therapy in the treatment of knee osteoarthritis |
ZHANG Hong1 WANG Xuyun2 ZHENG Weikang1 ZHANG Chunyan1 WEI Ni1 LIU Meiqi1 |
1.Department of Rheumatology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China;
2.Department of Traditional Chinese Medicine, Luhe Hospital, Capital Medical University, Beijing 101149, China |
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Abstract Knee osteoarthritis is a common chronic degenerative disease of knee joint. In the advanced stage, the joint may appear to bend and stretch limitation, crouch difficult, and some people even can′t walk when it′s serious. Drug treatment plays an important role in the clinical treatment of knee osteoarthritis, but rational drug use has not received much attention. Drug treatment include oral and topical drugs. Most patients take anti-inflammatory and analgesic drugs for a long time, and they are not aware of the indications and side effects of their treatment; some patients do not know enough about the application of external drugs. Oral drugs include analgesics, cartilage protection drugs; intra-articular injection of drugs include hyaluronic acid, sodium vitreate, medical chitin, hormone drugs, autorich platelet plasma, ozone, etc. In addition, there are also topical drugs. This article mainly summarizes the drugs for the treatment of knee osteoarthritis, in order to guide the clinical medication better and improve the therapeutic effect of knee osteoarthritis.
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[1] 张建环,朱群娣,钟建明.我院非甾体抗炎药在治疗膝骨关节炎中的临床应用分析[J].广东药学院学报,2014,30(4):486-488.
[2] 包德明.膝关节骨关节炎的治疗进展[J].中医正骨,2014, 26(12):52-55.
[3] 张志毅,段新旺,古洁若,等.欧洲骨质疏松和骨关节炎临床及经济学协会(ESCEO)和中国骨关节炎领域专家联合发表声明:ESCEO膝骨关节炎治疗规则应同样适用于中国患者[J].中国实用内科杂志,2016,36(9):762-772.
[4] 杨玉鹏,田烨.塞来昔布治疗骨关节炎患者的有效性和安全性[J].中国老年学杂志,2014,34(1):5-7.
[5] 孟敏,刘丽春,葛斌,等.塞来昔布治疗类风湿性关节炎或骨关节炎疗效和安全性的Meta分析[J].中国循证医学杂志,2011,11(5):560-564.
[6] 刘峰.硫酸氨基葡萄糖胶囊治疗膝骨关节炎的疗效观察[J].中国医药指南,2017,12(31):100-101.
[7] 郭丽.硫酸氨基葡萄糖治疗膝骨关节炎的临床疗效分析[J].世界最新医学信息文摘,2016,16(A3):128.
[8] 卢宏伟,罗飞,侯天勇,等.硫酸氨基葡萄糖联合非甾体抗炎药在轻中度膝骨关节炎中的作用[J].中国医药导报,2016,13(17):137-139,148.
[9] 张英,关继奎.白细胞介素-1、基质金属蛋白酶-1在膝关节骨性关节炎发病中的作用探讨[J].福建医药杂志,2005,27(6):128-131.
[10] Rimshaw J,Trocha-Grimshaw J,Fisher W,et al. Quantitative analysis of hyaluronan in human synovial fluid using capillary electrophoresis [J]. Electrophoresis,1996, 17(2):396-400.
[11] 邹国友,郑闽前,贾伟涛,等.富血小板血浆与透明质酸钠关节腔内注射治疗膝骨关节炎的疗效比较[J].中华损伤与修复杂志:电子版,2014,9(6):630-633.
[12] 应振华.膝骨关节炎治疗的新观点(新趋势)[A].浙江省医学会风湿病学分会.二零一四年浙江省风湿病学学术年会论文汇编[C].浙江省医学会风湿病学分会,2014:2.
[13] 白玉明,张海森,刘畅,等.玻璃酸钠关节腔注射对膝骨关节炎患者关节液及血浆中白介素-17的影响[J].中国医药导报,2017,14(19):118-121.
[14] 刘榆.玻璃酸钠治疗中度膝关节骨性关节炎的远期疗效评价[J].药品评价,2017,14(4):55-58.
[15] 冯文涛.玻璃酸钠关节腔内注入治疗膝骨关节炎的短期效果[J].中外医学研究,2017,15(8):134-136.
[16] 刘爱峰,裴开源,王平,等.玻璃酸钠注射液与生理盐水对照对于膝骨性关节炎临床疗效的Meta分析[J].中国矫形外科杂志,2016,24(17):1581-1586.
[17] 李尚娥,范海涛,张斌.膝关节腔内注射医用几丁糖治疗膝关节骨性关节炎的效果观察[J].中国医学前沿杂志:电子版,2016,8(11):84-87.
[18] 邓波.关节内注射PRP与HA治疗膝关节软骨退行性变疗效的Meta分析[D].大连:大连医科大学,2017:106-108.
[19] 杨顺刚,江川,顾鑫锋,等.糖皮质激素与透明质酸钠序贯性治疗膝关节骨性关节炎的疗效比较[J].中国骨与关节损伤杂志,2015,30(10):1052-1054.
[20] 单龙飞,李会杰,马云辉.复方倍他米松联合玻璃酸钠治疗膝骨关节炎临床观察[J].中国农村卫生,2014(11):12.
[21] Duymus TM,Mutlu S,Dernek B,et al. Choice of intra-articular injection in treatment of knee osteoarthritis:platelet-rich plasma,hyaluronic acid or ozone options [J]. Knee Surg Sport Tr A,2016,25(2):1-8.
[22] 崔桂华.富血小板血浆与透明质酸钠治疗膝骨关节炎的效果比较[J].中国当代医药,2018,25(16):102-104, 117.
[23] 王一帆,李小峰,罗道明,等.关节腔内注射自体富血小板血浆治疗膝关节骨性关节炎的临床疗效[J].广西医学,2017,39(9):1304-1308.
[24] 叶阮炷,韩清民.臭氧和PRP治疗膝骨性关节炎的临床效果观察[J].河北医学,2017,23(5):832-835.
[25] 李艳红,朱长德,李艳秋.臭氧关节腔内注射治疗膝骨性关节炎及对血清IL-12的影响[J].中国疼痛医学杂志,2014,20(7):512-514.
[26] Bocci V,Valacchi G. Free radicals and antioxidants:how to reestablish redox homeostasis in chronic diseases [J]. Curr Med Chem,2013,20(27):3397-3415.
[27] 姚东文,陈琳,马赛.臭氧关节腔注射治疗早、中、晚期膝骨关节炎的研究[J].中国疼痛医学杂志,2016,22(6):474-476.
[28] 鄢卫平,柳直.臭氧治疗膝骨关节炎临床观察[J].卫生职业教育,2012,30(5):151-152.
[29] 颜立军.探讨关节镜清理术联合低浓度臭氧腔内注射治疗膝骨关节炎的临床疗效[J].中国医学创新,2016, 13(24):30-34.
[30] 邢润麟,茆军,王培民,等.国外局部外用药控制膝骨关节炎疼痛的临床研究进展[J].中国疼痛医学杂志,2016, 22(2):133-136.
[31] 刘月,许建允,林敏.艾灸治疗膝骨关节炎的系统性评价及Meta分析[J].临床和实验医学杂志,2017,16(8):783-787. |
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