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| Analysis of the medication rule of Professor Cheng Weiping in the treatment of Gilles de la Tourette syndrome#br# |
| LIU Yue1 CHENG Guangyu2 CHENG Weiping3 |
1.Graduate School, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150001, China;
2.Diagnosis and Treatment Center of Epilepsy, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150001, China;
3.the Second Department of Acupuncture, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150001, China |
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Abstract Objective To summarize the prescription and medication rule of Professor Cheng Weiping in the treatment of Gilles de la Tourette syndrome. Methods The electronic medical record data of the outpatient Department of Professor Cheng Weiping of Heilongjiang University of Chinese Medicine from January 2018 to June 2021 were extracted, relevant medical records were screened and processed, and were input into the traditional Chinese medicine inheritance assistance platform (V3.0). Statistical methods such as frequency analysis, cluster analysis, and association rules were used to summarize the core drugs and summarize the rules of differentiation and treatment. Results A total of 94 prescriptions involving 101 Chinese medicines were included. The four nature of drugs were mainly composed of plain medicine and warm medicine. The five flavours were mainly sweet taste and bitter taste. The main channels were lung channel and heart channel. The drugs with the frequency ≥30 times included 14 herbs, such as prepared stir-frying with tortoise plastron, Gastrodiae Rhizoma, Rehmanniae Radix, and Glycurrhizae Radix Et Rhizoma Praeparata Cum Melle. The most frequently used drugs were tonify deficiency medicine. There were 19 groups of high frequency drug combinations with frequency ≥45 times; there were 33 pairs of commonly used drug combinations with confidence level ≥0.8. Four types of core drug combinations were obtained according to the results of drug cluster analysis. Conclusion Professor Cheng’s treatment of Gilles de la Tourette syndrome mainly focuses on tonifying kidney and tonifying and replenishing marrow and essence, suppressing hyperactive liver for calming endogenous wind, dispersing stagnated liver qi and softening liver.
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[1] Conte G，Valente F，Fioriello F，et al. Rage attacks in Tourette Syndrome and Chronic Tic Disorder：a systematic review [J]. Neurosci Biobehav Rev，2020，119：21-36. DOI：10.1016/j.neubiorev.2020.09.019.
[2] Domènech L，Cappi C，Halvorsen M. Genetic architecture of Tourette syndrome：our current understanding [J]. Psychol Med，2021，51（13）：2201-2209. DOI：10.1017/S0033 291721000234.
[3] Hallett M. Tourette Syndrome：Update [J]. Brain Dev，2015，37（7）：651-655. DOI：10.1016/j.braindev.2014.11.005.
[4] Baizabal-Carvallo JF，Alonso-Juarez M，Jankovic J. Self-injurious behavior in Tourette syndrome [J]. J Neurol， 2021. DOI：10.1007/s00415-021-10822-0. Epub ahead of print. PMID：34596744.
[5] 郭宁，李亚平.儿童抽动障碍中医治疗研究进展[J].陕西中医，2021，42（7）：983-984.
[6] 冯鹏，史正刚，孙治前，等.神经递质与抽动秽语综合征[J].重庆医科大学学报，2021，46（5）：516-521.
[7] 美国精神医学学会.精神疾病诊断与统计手册[M].北京：北京大学出版社，2015.
[8] Müller-Vahl KR，Szejko N，Verdellen C，et al. European clinical guidelines for Tourette syndrome and other tic disorders：summary statement [J]. Eur Child Adolesc Psychiatry，2022，31（3）：377-382.
[9] Johnson KA，Duffley G，Foltynie T，et al. Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome [J]. Biol Psychiatry Cogn Neurosci Neuroimaging，2021，6（10）：961-972. DOI：10.1016/j.bpsc.2020.11.005.
[10] Suh HW，Kwon CY，Hong S，et al. Nonpharmacological treatments for Tourette syndrome and tic disorders：A protocol for systematic review and network meta-analysis [J]. Medicine（Baltimore），2021，100（19）：e25741. DOI：10.1097/MD.0000000000025741.
[11] Set KK，Warner JN. Tourette syndrome in children：An update [J]. Curr Probl Pediatr Adolesc Health Care，2021，51（7）：101032. DOI：10.1016/j.cppeds.2021.101032.
[12] Nomura Y. Pharmacological therapy for Tourette syndrome：What medicine can do and cannot do [J]. Biomed J，2021；S2319-4170（21）00114-1. DOI：10.1016/j.bj.2021.09.002.
[13] 姜娴荷，史文丽，马丙祥.马丙祥教授辨治抽动秽语综合征用药规律分析[J].中西医结合心脑血管病杂志，2020， 18（16）：2581-2584.
[14] 严莉，李晶，卫义兰，等.四神针外刺配合艾灸治疗肾虚肝风型抽动秽语综合征的临床观察[J].中国中医药科技，2019，26（5）：732-734.
[15] 张永春，汪受传.汪受传从风痰论治儿童多发性抽动症经验[J].中华中医药杂志，2010，25（4）：549-550.
[16] 徐涛，纪战尚，王翠霞.滋阴潜阳熄风止搐法治疗抽动-秽语综合征36例[J].辽宁中医杂志，2010，37（3）：425-426.
[17] 姜妍，白晓红.清肝泻火法在小儿多发性抽动症治疗中的应用探讨[J].云南中医中药杂志，2020，41（11）：99-101.
[18] 李亚平，马融.基于“筋为刚”“肝主筋膜”理论浅析儿童抽动障碍的中医病机[J].中医杂志，2021，62（17）：1496-1499.
[19] 冯金花，蒋锴，庞日，等.清肝泻火法推拿治疗小儿抽动-秽语综合征的临床研究[J].中国中医药现代远程教育，2020，18（13）：97-99.
[20] 付玉芝.养血熄风汤加减治疗小儿抽动秽语综合征[J].中医临床研究，2020，12（1）：86-88.
[21] 刘萌萌，章柏钰，张伊，等.天麻多糖对中枢神经系统疾病作用的研究进展[J].中国药师，2021，24（10）：1882-1888.
[22] 谢学渊，任婷麟，安扬.天麻多糖对谷氨酸损伤HT22细胞的保护作用[J].解放军药学学报，2016，32（2）：120-123.
[23] 陈金鹏，张克霞，刘毅，等.地黄化学成分和药理作用的研究进展[J].中草药，2021，52（6）：1772-1784.
[24] Lee B，Shim I，Lee H，et al. Rehmannia glutinosa ameliorates scopolamine-induced learning and memory impairment in rats [J]. J Microbiol Biotechnol. 2011，21（8）：874-883. DOI：10.4014/jmb.1104.04012.
[25] 黄清杰，张中华，徐志伟.龟甲药用历史与研究进展[J].湖北中医杂志，2021，43（5）：64-66.
[26] 权浩浩，张晓凤，高凯，等.基于网络药理学的僵蚕主要药效作用研究[J].西部中医药，2021，34（3）：92-96.
[27] 但彩云，崔诗遥，李聪慧，等.白僵蚕活性成分及其药用功效的研究概况[J].蚕桑通报，2021，52（1）：1-5. |
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