前列腺癌组织中LncRNA LINC00355、miR-494-3p、CCND2的表达及临床意义

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (778 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the expression and clinical significance of long non-coding RNA (LncRNA) LINC00355, microRNA-494-3p (miRNA-494-3p), cyclin D2 (CCND2) mRNA expression in prostate cancer tissues. Methods A total of 91 prostate cancer patients admitted to Anhui NO.2 Provincial People’s Hospital from January 2015 to December 2017 were selected. qRT-PCR was used to detect the expression of LncRNA LINC00355, miR-494-3p, and CCND2 mRNA in cancer tissues and paracancer normal tissues of patients. Kaplan-Meier curve was used to analyze three-year survival rate after surgery of prostate cancers with different LncRNA LINC00355, miR-494-3p, and CCND2 mRNA expression. Results LncRNA LINC00355 and CCND2 mRNA expression in prostate cancer tissues were higher than those in paracancer normal tissues, and miR-494-3p expression was lower than that in paracancer normal tissues (P ＜ 0.05). LncRNA LINC00355 was negatively correlated with miR-494-3p expression and positively correlated with CCND2 mRNA expression in prostate cancer tissues (r = -0.502, 0.458, P ＜ 0.001), and miR-494-3p was negatively correlated with CCND2 mRNA expression (r = -0.493, P ＜ 0.001). The three-year overall survival rate after surgery in patients with high LncRNA LINC00355 expression, low miR-494-3p expression, and high CCND2 mRNA expression were lower than those in patients with low LncRNA LINC00355 expression, high miR-494-3p expression, and low CCND2 mRNA expression (P ＜ 0.05). Conclusion LncRNA LINC00355 and CCND2 expression are up-regulated and miR-494-3p expression is down-regulated in prostate cancer tissues. LncRNA LINC00355 may promote prostate cancer progression by inhibiting miR-494-3p and up-regulating CCND2 expression.

Key words： Prostate cancer Long non-coding RNA LINC00355 MicroRNA-494-3p

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XIE Dandan1 XIA Lei2 LI Songguo1 PAN Xianzhu1

Cite this article:

XIE Dandan1 XIA Lei2 LI Songguo1 PAN Xianzhu1. Expression and clinical significance of LncRNA LINC00355, miR-494-3p, and CCND2 mRNA in prostate cancer tissues#br#[J]. 中国医药导报, 2022, 19(11): 123-126.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I11/123

[1] 李星，曾晓勇.中国前列腺癌流行病学研究进展[J].肿瘤防治研究，2021，48（1）：98-102.
[2] 郑荣寿，孙可欣，张思维，等.2015年中国恶性肿瘤流行情况分析[J].中华肿瘤杂志，2019，41（1）：19-28.
[3] 孔琪，王章桂.晚期前列腺癌治疗进展[J].实用医学杂志，2021，37（3）：410-414.
[4] 肖楠，李占峰，姚建新，等.长链非编码RNA与肿瘤干细胞[J].协和医学杂志，2021，12（3）：373-379.
[5] 冯家乐，程继文.微小RNA与前列腺癌关系的研究进展[J].广西医学，2021，43（9）：1129-1132.
[6] Zhao W，Jin Y，Wu P，et al. LINC00355 induces gastric cancer proliferation and invasion through promoting ubiquitination of P53 [J]. Cell Death Discov，2020，6（1）：99.
[7] Yan L，Wang P，Fang W，et al. Cancer-associated fibroblasts-derived exosomes-mediated transfer of LINC00355 regulates bladder cancer cell proliferation and invasion [J]. Cell Biochem Funct，2020，38（3）：257-265.
[8] Jardim DL，Millis SZ，Ross JS，et al. Cyclin Pathway Genomic Alterations Across 190，247 Solid Tumors：Leveraging Large-Scale Data to Inform Therapeutic Directions [J]. Oncologist，2021，26（1）：e78-e89.
[9] Amin MB，Edge SB，Greene FL，et al. AJCC cancer staging manual [M]. 8th ed. New York：Springer，2017：715.
[10] 刘一锐，李柄恒，于海元，等.微小RNA-200a在前列腺癌组织的表达及临床意义[J].中华实验外科杂志，2020， 37（2）：356-359.
[11] 王明生，李均，吴志平.长链非编码RNA在前列腺癌中的研究进展[J].医学综述，2020，26（5）：915-919.
[12] Zhou F，Lei Y，Xu X，et al. LINC00355：8 promotes cell proliferation and migration with invasion via the MiR-6777-3p/Wnt10b axis in Hepatocellular Carcinoma [J]. J Cancer，2020，11（19）：5641-5655.
[13] Ruan Z，Deng H，Liang M，et al. Overexpression of long non-coding RNA00355 enhances proliferation，chemotaxis，and metastasis in colon cancer via promoting GTF2B-mediated ITGA2 [J]. Transl Oncol，2021，14（1）：100947.
[14] 李玖明，崔凯飒，王雪，等.Linc00355在结肠癌中表达上调并促进肿瘤细胞增殖和侵袭[J].肿瘤，2021，41（3）：175-185.
[15] Jiang T，Guo J，Hu Z，et al. Identification of Potential Prostate Cancer-Related Pseudogenes Based on Competitive Endogenous RNA Network Hypothesis [J]. Med Sci Monit，2018，24：4213-4239.
[16] 张建育，李毅宁，郭一泓，等.LINC00355调控miR-494-3p/CCND2对前列腺癌细胞增殖、侵袭、迁移的影响[J].中国免疫学杂志，2021，37（5）：564-570.
[17] Khan AQ，Ahmed EI，Elareer NR，et al. Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies [J]. Cells，2019，8（8）：840.
[18] Wei W，Ji L，Duan W，et al. Circular RNA circ_0081001 knockdown enhances methotrexate sensitivity in osteosarcoma cells by regulating miR-494-3p/TGM2 axis [J]. J Orthop Surg Res，2021，16（1）：50.
[19] Zhu L，Wang X，Wang T，et al. miR-494-3p promotes the progression of endometrial cancer by regulating the PTEN/PI3K/AKT pathway [J]. Mol Med Rep，2019，19（1）：581-588.
[20] Chen SM，Wang BY，Lee CH，et al. Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells [J]. Oncotarget，2017，8（44）：76057-76068.
[21] I?鬤bilir A，M?觟ller J，Arimont M，et al. Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists [J]. Proc Natl Acad Sci U S A，2020，117（46）：29144-29154.
[22] Shen PF，Chen XQ，Liao YC，et al. MicroRNA-494-3p targets CXCR4 to suppress the proliferation，invasion，and migration of prostate cancer [J]. Prostate，2014，74（7）：756-767.
[23] Ouyang J，Liu Z，Yuan X，et al. LncRNA PRNCR1 Promotes Breast Cancer Proliferation and Inhibits Apoptosis by Modulating microRNA-377/CCND2/MEK/MAPK Axis [J]. Arch Med Res，2021，52（5）：471-482.
[24] 皮益苑，周爽，简鸣，等.LncRNA中miRNA海绵活性与肿瘤的研究进展[J].中南医学科学杂志，2019，47（3）：230-234.
[25] Aghdam AM，Amiri A，Salarinia R，et al. MicroRNAs as Diagnostic，Prognostic，and Therapeutic Biomarkers in Prostate Cancer [J]. Crit Rev Eukaryot Gene Expr，2019， 29（2）：127-139.