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| Research progress of mild traumatic brain injury biomarkers |
| CHEN Zhongyan1* ZHONG Ruixia1* QIN Yajing1 SUN Hongtao1 LIU Yang2▲ |
1.Department of Neurological Intensive Care Unit, Affiliated Hospital of Logistics College of PAP, Tianjin 300162, China;
2.Department of Neurology, the Fourth People′s Hospital of Shanghai, Shanghai 200081, China |
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Abstract The incidence of mild traumatic brain injury (mTBI) has remained high and has become a worldwide public health problem. There is a pressing need for better practice guidelines in clinic to standardize mTBI clinics, thereby providing mTBI patients with a timetable to return to work safe. Imaging studies are not yet sensitive to the diagnosis of mTBI, and the development of a set of biomarkers that can reflect the underlying pathophysiology of mTBI, that will contribute to clinical diagnosis and prognostic of mTBI. Based on the pathological anatomy and pathophysiology of mTBI, this article systematically elaborates the advancements of blood-brain barrier disruption, axonal injury, neuroinflammation, and gene biomarkers, in order to discover some promising biomarkers that are availible in clinic and promote mTBI objective diagnosis and personalized treatment.
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[1] Feigin VL，Theadom A，Barker-Collo S，et al. Incidence of traumatic brain injury in New Zealand：a population-based study [J]. Lancet Neurol，2013，12（1）：53-64.
[2] Stuss DT. Traumatic brain injury：relation to executive dysfunction and the frontal lobes [J]. Curr Opin Neurol，2011， 24（6）：584-589.
[3] McCrory P. Traumatic brain injury：revisiting the AAN guidelines on sport-related concussion [J]. Nat Rev Neurol，2013，9（7）：361-362.
[4] Hadanny A，Efrati S. Treatment of persistent post-concussion syndrome due to mild traumatic brain injury：current status and future directions [J]. Expert review of neurotherapeutics，2016，16（8）：875-887.
[5] Giza CC，Hovda DA. The new neurometabolic cascade of concussion [J]. Neurosurgery，2014，75（Suppl 4）：S24-S33.
[6] Vagnozzi R，Signoretti S，Cristofori L，et al. Assessment of metabolic brain damage and recovery following mild traumatic brain injury：a multicentre，proton magnetic resonance spectroscopic study in concussed patients [J]. Brain，2010，133（11）：3232-3242.
[7] Vagnozzi R，Signoretti S，Tavazzi B，et al. Temporal window of metabolic brain vulnerability to concussion：a pilot 1H-magnetic resonance spectroscopic study in concussed athletes—part Ⅲ [J]. Neurosurgery，2008，62（6）：1286-1295.
[8] Giza CC，Hovda DA. The neurometabolic cascade of concussion [J]. J Athl Train，2001，36（3）：228-235.
[9] Blennow K，Hampel H，Weiner M，et al. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease [J]. Nat Rev Neurol，2010，6（3）：131-144.
[10] Shahim P，Tegner Y，Marklund N，et al. Astroglial activation and altered amyloid metabolism in human repetitive concussion [J]. Neurology，2017，88（15）：1400-1407.
[11] Cummins PM. Occludin：one protein，many forms [J]. Mol Cell Biol，2012，32（2）：242-250.
[12] Saitou M，Ando-Akatsuka Y，Itoh M，et al. Mammalian occludin in epithelial cells：its expression and subcellular distribution [J]. Eur J Cell Biol，1997，73（3）：222-231.
[13] Marchi N，Rasmussen P，Kapural M，et al. Peripheral markers of brain damage and blood-brain barrier dysfunction [J]. Restor Neurol Neurosci，2003，21（3-4）：109-121.
[14] Pham N，Akonasu H，Shishkin R，et al. Plasma soluble prion protein，a potential biomarker for sport-related concussions：a pilot study [J]. PLoS One，2015，10（2）：e0117286.
[15] Kochanek PM，Dixon CE，Shellington DK，et al. Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats [J]. J Neurotrauma，2013，30（11）：920-937.
[16] Büki A，Povlishock JT. All roads lead to disconnection?—Traumatic axonal injury revisited [J]. Acta Neurochir （Wien），2006，148（2）：181-193.
[17] Wang Y，Mandelkow E. Tau in physiology and pathology [J]. Nat Rev Neurosci，2016，17（1）：5-21.
[18] Choe MC. The pathophysiology of concussion [J]. Curr Pain Headache Rep，2016，20（6）：42.
[19] Rubenstein R，Chang B，Yue JK，et al. Comparing plasma phospho tau，total tau，and phospho tau-total tau ratio as acute and chronic traumatic brain injury biomarkers [J]. JAMA Neurol，2017，74（9）：1063-1072.
[20] Wilkinson KD，Lee KM，Deshpande S，et al. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase [J]. Science，1989，246（4930）：670-673.
[21] Jeter CB，Hergenroeder GW，Hylin MJ，et al. Biomarkers for the diagnosis and prognosis of mild traumatic brain injury/concussion [J]. J Neurotrauma，2013，30（8）：657-670.
[22] Kou Z，Gattu R，Kobeissy F，et al. Combining biochemical and imaging markers to improve diagnosis and characterization of mild traumatic brain injury in the acute setting：results from a pilot study [J]. PLoS One，2013，8（11）：e80296.
[23] Papa L，Lewis LM，Silvestri S，et al. Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention [J]. J Trauma Acute Care Surg，2012，72（5）：1335-1344.
[24] Puvenna V，Brennan C，Shaw G，et al. Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits [J]. PLoS One，2014，9（5）：e96296.
[25] Johnson VE，Stewart W，Smith DH. Axonal pathology in traumatic brain injury [J]. Exp Neurol，2013，246：35-43.
[26] Gatson JW，Barillas J，Hynan LS，et al. Detection of neurofilament-H in serum as a diagnostic tool to predict injury severity in patients who have suffered mild traumatic brain injury [J]. J Neurosurg，2014，121（5）：1232-1238.
[27] B?觟hmer AE，Oses JP，Schmidt AP，et al. Neuron-specific enolase，S100B，and glial fibrillary acidic protein levels as outcome predictors in patients with severe traumatic brain injury [J]. Neurosurgery，2011，68（6）：1624-1630.
[28] Olsson B，Zetterberg H，Hampel H，et al. Biomarker-based dissection of neurodegenerative diseases [J]. Prog Neurobiol，2011，95（4）：520-534.
[29] McMahon PJ，Panczykowski DM，Yue JK，et al. Measurement of the glial fibrillary acidic protein and its breakdown products GFAP-BDP biomarker for the detection of traumatic brain injury compared to computed tomography and magnetic resonance imaging [J]. J Neurotrauma，2015，32（8）：527-533.
[30] Bogoslovsky T，Wilson D，Chen Y，et al. Increases of plasma levels of glial fibrillary acidic protein，tau，and amyloid β up to 90 days after traumatic brain injury [J]. J Neurotrauma，2017，34（1）：66-73.
[31] Berger RP，Adelson PD，Pierce MC，et al. Serum neuron-specific enolase，S100B，and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children [J]. J Neurosurg，2005，103（1 Suppl）：61-68.
[32] Kulbe JR，Geddes JW. Current status of fluid biomarkers in mild traumatic brain injury [J]. Exp Neurol，2016，275 Pt 3：334-352.
[33] Siman R，Giovannone N，Hanten G，et al. Evidence that the blood biomarker SNTF predicts brain imaging changes and persistent cognitive dysfunction in mild TBI patients [J]. Front Neurol，2013，4：190.
[34] Berger RP，Hayes RL，Richichi R，et al. Serum concentrations of ubiquitin C-terminal hydrolase-L1 and αⅡ-spectrin breakdown product 145 kDa correlate with outcome after pediatric TBI [J]. J Neurotrauma，2012，29（1）：162-167.
[35] Mishra J，Ma Q，Prada A，et al. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury [J]. J Am Soc Nephrol，2003，14（10）：2534-2543.
[36] Dong M，Xi G，Keep RF，et al. Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats [J]. Brain Res，2013，1505：86-92.
[37] Zhao J，Xi G，Wu G，et al. Deferoxamine attenuated the upregulation of lipocalin-2 induced by traumatic brain injury in rats [J]. Acta Neurochir Suppl，2016，121：291-294.
[38] Zhao J，Chen H，Zhang M，et al. Early expression of serum neutrophil gelatinase-associated lipocalin（NGAL）is associated with neurological severity immediately after traumatic brain injury [J]. J Neurol Sci，2016，368：392-398.
[39] Habgood MD，Bye N，Dziegielewska KM，et al. Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice [J]. Eur J Neurosci，2007，25（1）：231-238.
[40] Goodman JC，Van M，Gopinath SP，et al. Pro-inflammatory and pro-apoptotic elements of the neuroinflammatory response are activated in traumatic brain injury [J]. Acta Neurochir Suppl，2008，102：437-439.
[41] Berger RP，Ta′asan S，Rand A，et al. Multiplex assessment of serum biomarker concentrations in well-appearing children with inflicted traumatic brain injury [J]. Pediatr Res，2009，65（1）：97-102.
[42] Tian J，Haller S，Periyasamy S，et al. Renal ischemia regulates marinobufagenin release in humans [J]. Hypertension，2010，56（5）：914-919.
[43] Oliver J，Abbas K，Lightfoot JT，et al. Comparison of neurocognitive testing and the measurement of marinobufagenin in mild traumatic brain injury：a preliminary report [J]. J Exp Neurosci，2015，9：67-72.
[44] Liu CC，Kanekiyo T，Xu H，et al. Apolipoprotein E and Alzheimer disease：risk，mechanisms and therapy [J]. Nat Rev Neurol，2013，9（2）：106-118.
[45] Lawrence DW，Comper P，Hutchison MG，et al. The role of apolipoprotein E episilon（ε）-4 allele on outcome following traumatic brain injury：a systematic review [J]. Brain Inj，2015，29（9）：1018-1031.
[46] Dretsch MN，Williams K，Emmerich T，et al. Brain-derived neurotropic factor polymorphisms，traumatic stress，mild traumatic brain injury，and combat exposure contribute to postdeployment traumatic stress [J]. Brain Behav，2016，6（1）：e00392 |
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