外放射治疗联合内分泌治疗对前列腺癌根治术后生化复发患者的影响

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Abstract Objective To evaluate the effects of external radiotherapy combined with endocrine therapy on patients with biochemical recurrence after radical prostatectomy. Methods A total of 132 patients with biochemical recurrence after radical prostatic cancer surgery in Department of Urology, Xuzhou Central Hospital of Jiangsu Province from January 2010 to December 2018 were selected. According to the different treatment regimens after biochemical recurrence, the patients were divided into three groups: external radiotherapy group (36 cases), endocrine therapy group (45 cases), and combined treatment group (external radiotherapy combined with endocrine therapy, 51 cases). The clinical data of the three groups were collected and compared, and the survival and adverse reactions of the three groups were compared after follow-up. Results There were no significant differences in age, body mass index, preoperative prostate specific antigen (PSA), Gleason score, clinical stage, and PSA doubling time among the three groups (P ＞ 0.05). All patients were followed up for 24 to 132 months, with a median follow-up of 63.5 months. Biochemical recurence-free survival rates were 50.0%, 51.1% and 66.7% in the external radiotherapy group, the endocrine therapy group, and the combination treatment group, with median survival rates of 62.0, 67.9, and 78.1 months, respectively. The biochemical recurence-free survival rates in the combination treatment group were higher than those in the external radiotherapy group and the endocrine therapy group, the difference was statistically significant (P ＜ 0.05). There were no significant differences in the incidence of hot flashes, urethral reactions, intestinal reactions, and sexual dysfunction among the three groups (P ＞ 0.05). Conclusion For patients with biochemical recurrence after radical prostatectomy, the combination of external radiotherapy and endocrine therapy group had more advantages in prolonging median survival time, and there was no significant difference in adverse reactions. Overall, the balance between survival benefit and treatment safety was better achieved.

Key words： Prostate cancer Biochemical recurrence Endocrine therapy Radiotherapy

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	WEI Zhenning1
	2 WANG Xitao2 SHI Zhenduo2 HAO Lin2 ZHOU Jiahe2 XIA Tian3 DU Junfei3 HAN Conghui1
	2▲

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WEI Zhenning1,2 WANG Xitao2 SHI Zhenduo2 HAO Lin2 ZHOU Jiahe2 XIA Tian3 DU Junfei3 HAN Conghui1,2▲. Effects of external radiotherapy combined with endocrine therapy on patients with biochemical recurrence after radical prostatectomy#br#[J]. 中国医药导报, 2022, 19(11): 103-106.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I11/103

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