Prediction research of the levels of plasma uric acid, atrial natriuretic peptide, and endothelin-1 with acute ST segment elevation myocardial infarction complicated with atrial fibrillation#br#
ZHAO Xiaohui LU Shuangdong CHEN Jie XU Yang WANG Huizhe
Department of Emergency, the Second Central Hospital of Baoding, Hebei Province, Baoding 072750, China
Abstract Objective To analyze the predictive value of the levels of plasma uric acid (UA), atrial natriuretic peptide (ANP), and endothelin-1 (ET-1) with acute ST segment elevation myocardial infarction (STEMI) complicated with atrial fibrillation. Methods A total of 156 newly diagnosed STEMI patients admitted to the Second Central Hospital of Baoding from January 2019 to may 2020 were selected for routine treatment and follow-up, and the incidence of atrial fibrillation was counted, and divided into concurrent group and non concurrent group according to whether complicated or not atrial fibrillation. The predictive value of the risk factors, each index alone, and in combination for patients with atrial fibrillation were analyzed. Results Age, body mass index (BMI), complication of ischemic cerebrovascular disease, complication of diabetes, complication of hypertension, complication of hyperlipidemia, left atrial diameter ＞ 50 mm at initial diagnosis, cardiac function Killip classification＞Ⅱ grade, newly diagnosed carbohydrate antigen (CA) 125 level, newly diagnosed UA level, newly diagnosed ANP level, newly diagnosed ET-1 level, and non-compliance with medical advice in the occurrence group were higher than those in the non-occurrence group (P ＜ 0.05). Age, BMI, complication of ischemic cerebrovascular disease, complication of diabetes, complication of hypertension, complication of hyperlipidemia, left atrial diameter ＞ 50 mm at initial diagnosis, cardiac function Killip classification＞Ⅱ grade, newly diagnosed CA125 level, newly diagnosed UA level, newly diagnosed ANP level, newly diagnosed ET-1 level, and non-compliance with medical advice were all risk factors for patients with atrial fibrillation (R ＞ 1, P ＜ 0.05). Receiver operating characteristic curve showed that the area under the curve of joint prediction was higher than that of separate prediction (Z = 3.867, P = 0.001; Z = 2.838, P = 0.005; Z = 2.650, P = 0.008). Conclusion The plasma levels of UA, ANP, ET-1, and age, BMI are all risk factors of atrial fibrillation, and the combination of the three indicators are more effective in predicting atrial fibrillation than the separate indicators.
ZHAO Xiaohui LU Shuangdong CHEN Jie XU Yang WANG Huizhe. Prediction research of the levels of plasma uric acid, atrial natriuretic peptide, and endothelin-1 with acute ST segment elevation myocardial infarction complicated with atrial fibrillation#br#[J]. 中国医药导报, 2022, 19(11): 73-76.
