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Prediction research of the levels of plasma uric acid, atrial natriuretic peptide, and endothelin-1 with acute ST segment elevation myocardial infarction complicated with atrial fibrillation#br# |
ZHAO Xiaohui LU Shuangdong CHEN Jie XU Yang WANG Huizhe |
Department of Emergency, the Second Central Hospital of Baoding, Hebei Province, Baoding 072750, China |
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Abstract Objective To analyze the predictive value of the levels of plasma uric acid (UA), atrial natriuretic peptide (ANP), and endothelin-1 (ET-1) with acute ST segment elevation myocardial infarction (STEMI) complicated with atrial fibrillation. Methods A total of 156 newly diagnosed STEMI patients admitted to the Second Central Hospital of Baoding from January 2019 to may 2020 were selected for routine treatment and follow-up, and the incidence of atrial fibrillation was counted, and divided into concurrent group and non concurrent group according to whether complicated or not atrial fibrillation. The predictive value of the risk factors, each index alone, and in combination for patients with atrial fibrillation were analyzed. Results Age, body mass index (BMI), complication of ischemic cerebrovascular disease, complication of diabetes, complication of hypertension, complication of hyperlipidemia, left atrial diameter > 50 mm at initial diagnosis, cardiac function Killip classification>Ⅱ grade, newly diagnosed carbohydrate antigen (CA) 125 level, newly diagnosed UA level, newly diagnosed ANP level, newly diagnosed ET-1 level, and non-compliance with medical advice in the occurrence group were higher than those in the non-occurrence group (P < 0.05). Age, BMI, complication of ischemic cerebrovascular disease, complication of diabetes, complication of hypertension, complication of hyperlipidemia, left atrial diameter > 50 mm at initial diagnosis, cardiac function Killip classification>Ⅱ grade, newly diagnosed CA125 level, newly diagnosed UA level, newly diagnosed ANP level, newly diagnosed ET-1 level, and non-compliance with medical advice were all risk factors for patients with atrial fibrillation (R > 1, P < 0.05). Receiver operating characteristic curve showed that the area under the curve of joint prediction was higher than that of separate prediction (Z = 3.867, P = 0.001; Z = 2.838, P = 0.005; Z = 2.650, P = 0.008). Conclusion The plasma levels of UA, ANP, ET-1, and age, BMI are all risk factors of atrial fibrillation, and the combination of the three indicators are more effective in predicting atrial fibrillation than the separate indicators.
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[1] Vogel B,Claessen BE,Arnold SV,et al. ST-segment elevation myocardial infarction [J]. Nat Rev Dis Primers,2019, 5(1):39.
[2] 孙闯,王婷婷,任何,等.比索洛尔与美托洛尔用于急性ST段抬高型心肌梗死PCI术后患者心率及心率变异性的比较[J].心脏杂志,2019,31(2):148-152.
[3] 俞晓雯.急性ST段抬高型心肌梗死患者PCI术后心房颤动发生的预测因素[J].山东医药,2018,58(17):55-57.
[4] 黄亚敏,全力力,黎明江.血尿酸水平对扩张型心肌病患者心房颤动发生的影响[J].山东医药,2019,59(1):73-76.
[5] Sramko M,Wichterle D,Melenovsky V,et al. Independent effect of atrial fibrillation on natriuretic peptide release [J]. Clin Res Cardiol,2019,108(2):142-149.
[6] 赵越超,刘少奎,王筱梅.急性心肌梗死后并发心房颤动患者RDW、ET及NT-proBNP水平变化及其与预后的关系[J].标记免疫分析与临床,2019,26(2):220-224.
[7] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会.急性ST段抬高型心肌梗死诊断和治疗指南[J].中华心血管病杂志,2015,43(5):380-393.
[8] 董剑廷.ACC/AHA/ESC2006年心房颤动指南[J].中国煤炭工业医学杂志,2007,10(1):51.
[9] 高贝贝,王龙,林晓晓,等.单核细胞/高密度脂蛋白,单核细胞/淋巴细胞与急性ST段抬高型心肌梗死直接PCI术后的影响[J].心脑血管病防治,2020,20(1):58-62.
[10] 张诗吟,廖海红,李国栋.急性ST段抬高型心肌梗死患者急性期冠状动脉病变评分与血清胱抑素C水平的相关性[J].中国医药导报,2019,16(8):137-141.
[11] 刘日,王永顺.急诊PCI术前fQRS与STEMI患者病情严重程度及术后主要心脏不良事件的关系[J].中华全科医学,2019,17(7):1128-1131.
[12] 闫杰松,周栋,汤祥瑞,等.心电图aVR T波形态与ST段抬高型心肌梗死患者冠状动脉病变程度的关系[J].中国医药导报,2020,17(8):82-85.
[13] 杨朋康,董昕.急性ST段抬高型心肌梗死患者血浆微小核糖核酸-208a水平对并发急性心力衰竭的预测价值[J].心肺血管病杂志,2020,39(4):49-53.
[14] 张智文,王山岭,刘静静,等.ST段抬高型心肌梗死患者直接经皮冠状动脉介入治疗和药物-侵入策略治疗下新发心房颤动的研究[J].临床心血管病杂志,2020, 36(6):540-544.
[15] 任锋,寇进,马兰香,等.左心室舒张功能不全联合左房容积指数预测急性ST段抬高型心肌梗死患者血运重建后持续性房颤的发生风险[J].武警医学,2020,31(3):219-223.
[16] 李贝贝,金至赓,李屹,等.单核细胞/高密度脂蛋白胆固醇比值对老年急性STEMI患者术后新发心房颤动的预测价值[J].武警医学,2019,30(1):15-18.
[17] 张迎花,华琦,李小明,等.血尿酸对急性ST段抬高型心肌梗死患者长期预后的影响[J].中华老年心脑血管病杂志,2016,18(5):474-477.
[18] 邵晓萍,孙亚召,白春林.尿酸对急性ST段抬高型心肌梗死介入治疗患者远期预后的影响[J].中华老年心脑血管病杂志,2019,21(6):612-614.
[19] 赵九洲,林晨,贺媛,等.核干细胞因子增强间充质干细胞心肌保护作用[J].心脏杂志,2019,31(6):621-626.
[20] 周小明,邓桂明,谭琦.培哚普利在冠心病经皮冠状动脉介入术后的应用效果及其对神经激素水平,内皮功能的影响[J].中国医药导报,2020,17(11):54-58.
[21] 罗晓亮,赵立超,赵彤,等.血浆大内皮素-1水平与心尖肥厚型心肌病伴发心房颤动的相关性研究[J].中国循环杂志,2019,34(3):252-255.
[22] 李彦明,何瑞利,钟晓鸣,等.急性ST段抬高型心肌梗死患者PCI术后预后评价模型的建立与研究[J].重庆医学,2019,48(1):71-75.
[23] 危凤藕,肇倩,建昌,等.达比加群酯与华法林用于冠心病合并心房颤动中的效果及安全性比较[J].中国医药科学,2020,10(20):99-102.
[24] 黄金波,张艳春,姜赛,等.急性心肌梗死患者新发心房颤动的危险因素及预后分析[J].中国心血管杂志,2019, 24(6):517-521.
[25] 侯朝凤,徐俊文,宋凤麟.老年心房颤动患者临床特征及危险因素分析[J].中华老年医学杂志,2020,39(8):870-873.
[26] 白玲玉,贺利平.心房颤动与Cys C,TGF-β1,TNF-α,CRP,CA125的研究进展[J].中西医结合心血管病电子杂志,2020,8(8):76-77. |
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