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| Effects of Lobeline on chronic neuropathic pain |
| YANG Ning1 FU Jie1 YIN Jiale1 CHEN Chunjiang1 XU Tianyi1 WANG Xue1 MA Tao2 |
1.School of Anesthesiology, Xuzhou Medical University, Jiangsu Province, Xuzhou 221004, China;
2.Department of Anesthetic Pharmacology, Xuzhou Medical University, Jiangsu Province, Xuzhou 221004, China |
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Abstract Objective To investigate the effects of Lobeline on chronic neuropathic pain. Methods Forty-eight mice aged 2 months were divided into 4 groups by random number table method and fed routinely: one group was blank control group, and chronic constriction injury model of sciatic nerve were prepared in the other three groups; model group (CCI + intraperitoneal injection of saline), low dose Lobeline group (CCI + intraperitoneal injection of 3 mg/kg Lobeline solution), high dose Lobeline group (CCI + intraperitoneal injection of 6 mg/kg Lobeline solution). The pain threshold and activity level of mice were measured by Von Fery mechanical pain measurement and open field test on the 1st, 8th, and 22nd days after injection. Results In the determination of pain threshold, the model group decreased on the 1st, 8th, and 22nd days after injection compared with the blank control group (P < 0.05). While compared with the model group, the high dose Lobeline group was elevated in the three experiments (P < 0.05). In the open field experiment, compared with the blank control group, the total distance and average speed of the model group significantly decreased on the 1st and 22nd days (P < 0.01). Compared with the model group, the total distance and mean velocity of the high dose Lobeline group on the 22th day increased significantly (P < 0.01), and the number of activities was improved (P < 0.05). Conclusion The 6 mg/kg Lobeline solution can increase the threshold of mice with chronic neuropathic pain and improve the mice′s depression-like behavior.
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