上海地区抽动障碍患儿血清25-羟基维生素D的差异性分析

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Abstract Objective To investigate the difference of serum 25- hydroxyvitamin D level in children with tic disorder (TD) in Shanghai. Methods From May 2018 to May 2020, 2001 children with TD aged 5 to 14 who visited the Department of Neurology of Shanghai Children’s Hospital (hereinafter referred to as “our hospital”) and 2670 normal children aged 5 to 14 who received physical examination in our hospital during the same period were selected. The serum 25-hydroxyvitamin D of children with TD was compared with that of normal children, and the serum 25-hydroxyvitamin D of children with TD with different characteristics was compared. Furthermore, children with TD were divided into five age groups according to one group every two years (24 months), including 5-6 years old group (655 cases), 7-8 years old group (237 cases), 9-10 old years group (610 cases), 11-12 years old group (342 cases), and 13-14 years old group (157 cases). The difference of 25- hydroxyvitamin D in the five groups was compared. Results The levels of serum 25-hydroxyvitamin D deficiency in children with TD was higher than those in normal children, the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in the levels of serum 25-hydroxyvitamin D deficiency among TD children with different residence, time of outdoor activities, personality of nuclear family members, eating habits, and study stress (P ＜ 0.05). The levels of serum 25-hydroxyvitamin D deficiency in 9-10 years old group, 11-12 years old group, and 13-14 years old group was higher than those in 5-6 years old group and 7-8 years old group, the differences were statistically significant (P ＜ 0.05). Conclusion There was a significant 25-hydroxyvitamin D deficiency in TD children in Shanghai, and the degree of 25-hydroxyvitamin D deficiency was different in TD children with different characteristics, and the deficiency was most significant in adolescents over nine years old.

Key words： 25-hydroxyvitamin D Tic disorder Children Level of deficiency

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	WANG Simei1 ZHANG Yuanfeng1 YUAN Fang1 CHEN Xuefen2 XI Jiaming1 LIU Zhiping1 CHEN Yucai1

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WANG Simei1 ZHANG Yuanfeng1 YUAN Fang1 CHEN Xuefen2 XI Jiaming1 LIU Zhiping1 CHEN Yucai1. Difference analysis of serum 25-hydroxyvitamin D levels in children with tic disorder in Shanghai#br#[J]. 中国医药导报, 2022, 19(11): 57-60,72.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I11/57

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